New Insights into Phase Separation Processes and Membraneless Condensates of EIN2

Recent technological advances allow us to resolve molecular processes in living cells with high spatial and temporal resolution. Based on these technological advances, membraneless intracellular condensates formed by reversible functional aggregation and phase separation have been identified as important regulatory modules in diverse biological processes. Here, we present bioinformatic and cellular studies highlighting the possibility of the involvement of the central activator of ethylene responses EIN2 in such cellular condensates and phase separation processes. Our work provides insight into the molecular type (identity) of the observed EIN2 condensates and on potential intrinsic elements and sequence motifs in EIN2-C that may regulate condensate formation and dynamics.

Automated summary

Recent technological advances have allowed us to study molecular processes in living cells with high resolution. This study focuses on membraneless intracellular condensates, which are reversible functional aggregates formed through phase separation. The research suggests the involvement of EIN2, a central activator of ethylene responses, in these cellular condensates and phase separation processes.