期刊
PLANTS-BASEL
卷 11, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/plants11192540
关键词
Grewia tomentosa Juss.; allergic inflammation; mast cell; passive cutaneous anaphylaxis; atopic dermatitis
资金
- National Institute of Biological Resources (NIBR) - Ministry of Environment (MOE) of the Republic of Korea [NIBR202106204, NIBR202207203]
- Korea Environmental Industry & Technology Institute (KEITI) [NIBR202207203] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study evaluates the anti-allergic and anti-topical dermatitis activity of Grewia tomentosa Juss. ethanol extract (Gt-EE). The results show that Gt-EE suppressed allergic responses and inflammation, indicating its potential as a medicinal herb.
Grewia tomentosa Juss. is a deciduous shrub that mainly grows in Asia. Despite studies of other Grewia species for treatment of various diseases, Grewia tomentosa Juss. has not been studied as a medicinal herb. This study evaluates the anti-allergic and anti-topic dermatitis activity of Grewia tomentosa Juss. ethanol extract (Gt-EE). The results show that Gt-EE suppressed IgE-antigeninduced beta-hexosaminidase release. The mRNA expression of IL-1 beta, IL-4, IL-5, IL-6, IL-13, TNF-alpha, MCP-1, and TSLP, which are involved in allergic responses, was inhibited by Gt-EE in IgE-stimulated RBL-2H3 cells. In addition, the phosphorylation of Syk, PLC gamma 1, PKG delta, PI3K, AKT, NF-kappa B p65, NF-kappa B p50, p38, JNK, and ERK1/2 was decreased by Gt-EE in these cells. Gt-EE also showed anti-inflammatory effects in in vivo mouse models. In passive cutaneous anaphylaxis (PCA), a commonly used mouse model, Gt-EE decreased the allergic response, infiltration of mast cells, and mRNA level of IL-4. Furthermore, Gt-EE ameliorated symptoms of DNCB-induced atopic dermatitis (AD). In DNCB-induced AD, Gt-EE suppressed the increase in mast cells, serum IgE level, expression of allergic mediators (IL-1 beta, IL-4, IL-5, IL-6, TNF-alpha), and phosphorylation of proteins (I kappa B alpha, NF-KB p65, NF-kappa B p50, p38, JNK, and ERK1/2) implicated in allergic reactions
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