期刊
BRAIN SCIENCES
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/brainsci12091154
关键词
schizophrenia; interleukin-2; immune response; neuroinflammation biomarker
资金
- Macau Science and Technology Development fund [FDCT 0089/2021/A]
- Faculty Research Grants ofMacau University of Science and Technology [FRG-21-039]
This article reviewed a series of studies and found a close association between interleukin-2 (IL-2) and schizophrenia. It discussed the changes of IL-2 in the onset, progression, and treatment of schizophrenia, as well as the possible mechanisms by which IL-2 affects schizophrenia.
Interleukin-2 (IL-2) is a growth factor that regulates T-cell autocrine secretion and has long been considered to be closely related to immune response. With the advance in neuroinflammation theory and immunology research on schizophrenia, it is interesting and meaningful to discuss the possible role of IL-2 in schizophrenia. Here, we reviewed a series of studies published from the 1990s and found that IL-2 was closely associated with schizophrenia. For example, IL-2 is responsible for mediating toxic reactions, which are the causes of schizophrenia symptoms in patients, and such symptoms resolve after discontinuation of the drug. In addition, we focused on the changes of IL-2 in the onset, progression and treatment of schizophrenia and the possible mechanisms by which IL-2 affects schizophrenia. Our review suggests that IL-2 is associated with schizophrenia and plays a role in its pathogenesis, and progression IL-2 and sIL-2R could serve as potential biomarkers of schizophrenia.
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