期刊
ANTIBIOTICS-BASEL
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11091201
关键词
OMN6; antimicrobial peptides; antimicrobial resistance; AMR; Acinetobacter baumannii; infectious diseases
资金
- Israeli Innovative Authority (IIA) - Israeli government [66782]
This study demonstrates the potent antimicrobial activity of the novel peptide OMN6 against multidrug-resistant Acinetobacter baumannii and its ability to avoid resistance development. In vivo experiments show that OMN6 is highly effective in treating life-threatening infections caused by multidrug-resistant A. baumannii.
The rapid worldwide spread of antimicrobial resistance highlights the significant need for the development of innovative treatments to fight multidrug-resistant bacteria. This study describes the potent antimicrobial activity of the novel peptide OMN6 against a wide array of drug-resistant Acinetobacter baumannii clinical isolates. OMN6 prevented the growth of all tested isolates, regardless of any pre-existing resistance mechanisms. Moreover, in vitro serial-passaging studies demonstrated that no resistance developed against OMN6. Importantly, OMN6 was highly efficacious in treating animal models of lung and blood infections caused by multidrug-resistant A. baumannii. Taken together, these results point to OMN6 as a novel antimicrobial agent with the potential to treat life-threatening infections caused by multidrug-resistant A. baumannii avoiding resistance.
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