☆ 4.6 Article

Prediction of Potential Natural Antibiotics Plants Based on Jamu Formula Using Random Forest Classifier

ANTIBIOTICS-BASEL (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Antimicrobial Activity of Dihydroisocoumarin Isolated from Wadi Lajab Sediment-Derived Fungus Penicillium chrysogenum: In Vitro and In Silico Study

Raha Orfali et al.

Summary: Antibiotic resistance is a major global health concern, and finding new antibiotics or antibiotic adjuvants to inhibit bacterial growth and overcome resistance is crucial. In this study, five potentially antibacterial compounds were discovered from sediment-derived fungus and showed good affinity with bacterial beta-Lactamase enzymes according to molecular docking data.

MOLECULES (2022)

添加到收藏夹

Article Biology

Fast bacterial growth reduces antibiotic accumulation and efficacy

Urszula Lapinska et al.

Summary: Phenotypic variations in microbial cells, driven by differences in drug transport rates, play a crucial role in the resistance of microbial pathogens to pharmacotherapies. This study used microfluidics-based single-cell microscopy and fluorescent antibiotic probes to identify phenotypic variants that avoid antibiotic accumulation. Surprisingly, fast growing variants were found to avoid macrolide accumulation and survive treatment without genetic mutations, contrary to current consensus. These fast growing variants also showed higher expression of ribosomal promoters, facilitating essential cellular processes and reducing macrolide accumulation. This new knowledge can be used to develop strategies to overcome antibiotic treatment failures.

ELIFE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Chrysophanol from the Roots of Kniphofia Insignis and Evaluation of Its Antibacterial Activities

Asnakew Amare Tadesse et al.

Summary: Sequential extraction of the roots of Kniphofia insignis using cold maceration techniques and column chromatographic separation led to the isolation of chrysophanol. Its structure was established through spectroscopic analyses and comparison with literature. Chrysophanol exhibited better inhibition against P. aeruginosa among the tested bacteria strains.

JOURNAL OF CHEMISTRY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared (FTIR) spectroscopy and machine learning

Bernardo Ribeiro da Cunha et al.

Summary: The study successfully employed high-throughput FTIR spectroscopy to discriminate the MOA of different antibiotics, achieving high accuracy through machine learning algorithms. Even at low concentrations and under growth inhibition, over 70% accuracy was achieved in predicting pathway and class.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

添加到收藏夹

Article Microbiology

Bacterial dormancy: A subpopulation of viable but non-culturable cells demonstrates better fitness for revival

Sariqa Wagley et al.

Summary: Members of the Proteobacteria can enter a viable but non culturable (VBNC) state as a survival strategy under stressful conditions. Using Vibrio parahaemolyticus as a model organism, distinct subpopulations in the VBNC state with different resuscitation potentials and proteomic profiles were identified. Deletion of the lactate dehydrogenase gene triggered cells to enter VBNC state, while lactate addition extended resuscitation potential. The ability to survive in VBNC state may be linked to overcoming oxidative stress.

PLOS PATHOGENS (2021)

添加到收藏夹

Article Infectious Diseases

Antibiotics' Use in Thailand: Community Pharmacists' Knowledge, Attitudes and Practices

Budh Siltrakool et al.

Summary: Thai community pharmacists demonstrate good knowledge, attitude, and practice regarding the use and resistance of antimicrobials. The most commonly encountered infections are upper and lower respiratory tract infections, and the most commonly dispensed antimicrobials are broad-spectrum antibiotics, including aminopenicillins and fluoroquinolones.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹

Review Infectious Diseases

Artificial Intelligence and Antibiotic Discovery

Liliana David et al.

Summary: The antibiotic crisis is mainly due to insufficient research, low return on investment, and the difficulty of the research process, leading to an increase in drug-resistant pathogens and threatening public health systems. The application of artificial intelligence technologies can accelerate antibiotic development and reduce costs, helping to solve the current crisis.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹

Article Microbiology

Persister Escherichia coli Cells Have a Lower Intracellular pH than Susceptible Cells but Maintain Their pH in Response to Antibiotic Treatment

Olivia Goode et al.

Summary: Persisters have a lower intracellular pH compared to VBNC and susceptible cells even before exposure to antibiotics, which is linked to the activity of the enzyme tryptophanase. In the absence of tryptophanase, there is no difference in intracellular pH among persister, VBNC, and susceptible E. coli cells.Whole-genome transcriptomic analysis showed that the regulation of intracellular pH varies within a clonal population, with a subset of cells displaying differential pH regulation to perform specific functions, including survival after antibiotic treatment.

MBIO (2021)

添加到收藏夹

Article Microbiology

The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

Liselot Dewachter et al.

Summary: Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections. Although some active persister mechanisms have been identified, the prevailing view is that cells become persistent because they enter a dormant state. We therefore characterized starvation-induced dormancy in Escherichia coli. Our findings indicate that dormancy develops gradually; persistence strongly increases during stationary phase and decreases again as persisters enter the viable but nonculturable (VBNC) state. Importantly, we show that dormancy development is tightly associated with progressive protein aggregation, which occurs concomitantly with ATP depletion during starvation. Persisters contain protein aggregates in an early developmental stage, while VBNC cells carry more mature aggregates. Finally, we show that at least one persister protein, ObgE, works by triggering aggregation, even at endogenous levels, and thereby changing the dynamics of persistence and dormancy development. These findings provide evidence for a genetically controlled, gradual development of persisters and VBNC cells through protein aggregation. IMPORTANCE While persistence and the viable but nonculturable (VBNC) state are currently investigated in isolation, our results strongly indicate that these phenotypes represent different stages of the same dormancy program and that they should therefore be studied within the same conceptual framework. Moreover, we show here for the first time that the dynamics of protein aggregation perfectly match the onset and further development of bacterial dormancy and that different dormant phenotypes are linked to different stages of protein aggregation. Our results thereby strongly hint at a causal relationship between both. Because many conditions known to trigger persistence are also known to influence aggregation, it is tempting to speculate that a variety of different persister pathways converge at the level of protein aggregation. If so, aggregation could emerge as a general principle that underlies the development of persistence which could be exploited for the design of antipersister therapies.

MBIO (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Deep Learning Approach to Antibiotic Discovery

Jonathan M. Stokes et al.

CELL (2020)

添加到收藏夹

Article Oncology

In vitro anti-bacterial activity of diosgenin on Porphyromonas gingivalis and Prevotella intermedia

Shaohua Cong et al.

MOLECULAR MEDICINE REPORTS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Promising View of Kudzu Plant, Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep: Flavonoid Phytochemical Compounds, Taxonomic Data, Traditional Uses and Potential Biological Activities for Future Cosmetic Application

Duangjai Tungmunnithum et al.

COSMETICS (2020)

添加到收藏夹

Review Integrative & Complementary Medicine

A Systematic Review on Traditional Uses, Sources, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Fritillariae Cirrhosae Bulbus

Ting Chen et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

添加到收藏夹

Article Infectious Diseases

Using Machine Learning Techniques to Aid Empirical Antibiotic Therapy Decisions in the Intensive Care Unit of a General Hospital in Greece

Georgios Feretzakis et al.

ANTIBIOTICS-BASEL (2020)

添加到收藏夹

Article Infectious Diseases

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

Alessandro Cassini et al.

LANCET INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Machine learning-powered antibiotics phenotypic drug discovery

Sannah Zoffmann et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Chemistry, Medicinal

Metabolomic Studies of Indonesian Jamu Medicines: Prediction of Jamu Efficacy and Identification of Important Metabolites

Sony Hartono Wijaya et al.

MOLECULAR INFORMATICS (2017)

添加到收藏夹

Article Biology

Investigating the physiology of viable but non-culturable bacteria by microfluidics and time-lapse microscopy

Rosemary A. Bamford et al.

BMC BIOLOGY (2017)

添加到收藏夹

Review Integrative & Complementary Medicine

Stachytarpheta jamaicensis (L.) Vahl: From Traditional Usage to Pharmacological Evidence

Pearl Majorie Liew et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Assembly and clustering of natural antibiotics guides target identification

Chad W. Johnston et al.

NATURE CHEMICAL BIOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Berberine Enhances the Antibacterial Activity of Selected Antibiotics against Coagulase-Negative Staphylococcus Strains in Vitro

Robert D. Wojtyczka et al.

MOLECULES (2014)

添加到收藏夹

Article Chemistry, Applied

Chemical constituents and antimicrobial properties of the essential oil and ethanol extract from the stem of Aglaia odorata Lour.

Nantiya Joycharat et al.

NATURAL PRODUCT RESEARCH (2014)

添加到收藏夹

Article Chemistry, Applied

Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves

Jianhua Xiong et al.

FOOD CHEMISTRY (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Brucin, an antibacterial peptide derived from fruit protein of Fructus Bruceae, Brucea javanica (L.) Merr.

T. Sornwatana et al.

LETTERS IN APPLIED MICROBIOLOGY (2013)

添加到收藏夹

Article Food Science & Technology

Effects of methanolic extract of sour cherry (Prunus cerasus L.) on microbial growth

Andrea Coccia et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2012)

添加到收藏夹

Article Plant Sciences

KNApSAcK Family Databases: Integrated Metabolite-Plant Species Databases for Multifaceted Plant Research

Farit Mochamad Afendi et al.

PLANT AND CELL PHYSIOLOGY (2012)

添加到收藏夹

Article Food Science & Technology

Insights into research on phytochemistry and biological activities of Prunus armeniaca L. (apricot)

Ilkay Erdogan-Orhan et al.

FOOD RESEARCH INTERNATIONAL (2011)

添加到收藏夹

Article Infectious Diseases

Methicillin-resistant Staphylococcus aureus: the superbug

Giuseppe Ippolito et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2010)

添加到收藏夹

Article Microbiology

Javanicin, an Antibacterial Naphthaquinone from an Endophytic Fungus of Neem, Chloridium sp.

Ravindra N. Kharwar et al.

CURRENT MICROBIOLOGY (2009)

添加到收藏夹

Article Biochemical Research Methods

Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by micro calorimetry

Dan Yan et al.

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS (2008)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents

KS Babu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

添加到收藏夹

Article Pharmacology & Pharmacy

Antimicrobial properties of silver-containing wound dressings: a microcalorimetric study

MAA O'Neill et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.