期刊
ANTIBIOTICS-BASEL
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antibiotics11081115
关键词
antibiotic resistance; antimicrobial activity; Escherichia coli; ESKAPE bacteria; dicationic compounds; sensitivity profiling
资金
- Centre for Antibiotic Resistance Research (CARe) at University of Gothenburg
- Lilly Lawski Foundation
- Coordination for the Improvement of Higher Education (CAPES), Brazil [STINT-PROJ-20181009558P]
Antibiotic resistance among bacteria is a growing global challenge, particularly for Gram-negative bacteria. In this study, the antibacterial activity of a dicationic bisguanidine-arylfuran compound and its derivatives was investigated. The compounds demonstrated good activity against antibiotic-resistant Gram-negative bacteria, including those with different antibiotic susceptibility patterns. Moreover, the derivatives showed lower cytotoxicity and higher selectivity indices compared to the lead molecule.
Antibiotic resistance among bacteria is a growing global challenge. A major reason for this is the limited progress in developing new classes of antibiotics active against Gram-negative bacteria. Here, we investigate the antibacterial activity of a dicationic bisguanidine-arylfuran, originally developed as an antitrypanosomal agent, and new derivatives thereof. The compounds showed good activity (EC50 2-20 mu M) against antibiotic-resistant isolates of the Gram-negative members of the ESKAPE group (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) and Escherichia coli with different antibiotic susceptibility patterns, including ESBL isolates. Cytotoxicity was moderate, and several of the new derivatives were less cytotoxic than the lead molecule, offering better selectivity indices (40-80 for several ESKAPE isolates). The molecular mechanism for the antibacterial activity of these molecules is unknown, but sensitivity profiling against human ESKAPE isolates and E. coli collections with known susceptibility patterns against established antibiotics indicates that it is distinct from lactam and quinolone antibiotics.
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