4.6 Article

Antimicrobial Resistance and Biofilms Underlying Catheter-Related Bloodstream Coinfection by Enterobacter cloacae Complex and Candida parapsilosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Public, Environmental & Occupational Health

Insights on catheter-related bloodstream infections: a prospective observational study on the catheter colonization and multidrug resistance

M. Pinto et al.

Summary: This study aimed to identify the major causative agents of central venous catheter-related bloodstream infection (CRBSI) and investigate their antimicrobial resistance and colonization ability. The study found that staphylococci were the most prevalent causative agents, but there was no significant association between biofilm formation and bloodstream infection.

JOURNAL OF HOSPITAL INFECTION (2022)

Article Public, Environmental & Occupational Health

Increase in the frequency of catheter-related bloodstream infections during the COVID-19 pandemic: a plea for control

M. J. Perez-Granda et al.

Summary: The incidence of catheter-related bloodstream infections (CR-BSIs) significantly increased during the COVID-19 pandemic, highlighting the need for enhanced preventive measures.

JOURNAL OF HOSPITAL INFECTION (2022)

Article Infectious Diseases

Comparative resistome and virulome analysis of clinical NDM-1-producing carbapenem-resistant Enterobacter cloacae complex

Negin Bolourchi et al.

Summary: The study assembled and characterized the whole genomes of four clinical carbapenem-resistant Enterobacter cloacae complex (ECC) strains, providing insights into their antimicrobial resistance (AMR) and virulence profiles. The findings highlight the accumulation of AMR genes in Enterobacter spp. and their high endurance in hostile environments as a serious health problem.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

Article Infectious Diseases

Fluconazole-resistant Candida parapsilosis clonally related genotypes: first report proving the presence of endemic isolates harbouring the Y132F ERG11 gene substitution in Spain

Eva Alcoceba et al.

Summary: This study reports the presence of Candida parapsilosis isolates resistant to fluconazole in patients admitted to a Spanish hospital. These isolates carry the Y132F ERG11 gene substitution and are mainly found in catheter and blood culture samples. The resistance is attributed to the endemic spread of multiple resistant genotypes within the hospital, rather than prior azole use.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

Article Infectious Diseases

Clinical and microbiological characteristics of polymicrobial bacteremia: a retrospective, multicenter study

Shinnosuke Fukushima et al.

Summary: This study aimed to clarify the clinical and microbial characteristics of polymicrobial bacteremia (PMB) and found that intra-abdominal infections were the most common source, particularly associated with the combination pattern of Gram-positive cocci (chain form)/Gram-negative rods (GNR). Patients with an identified infectious focus had a better prognosis, highlighting the importance of early diagnosis and appropriate treatment.

INFECTION (2022)

Article Biotechnology & Applied Microbiology

Risk Factors for and Clinical Outcomes of Polymicrobial Acinetobacter baumannii Bloodstream Infections

Zhenhua Qian et al.

Summary: Polymicrobial Acinetobacter baumannii bloodstream infection is relatively rare, mostly originating from skin and soft tissue infections, with burn injury being an independent risk factor. Patients with polymicrobial infection had longer hospital stays and more days of hospitalization after infection compared to those with monomicrobial infection. However, there was no significant difference in mortality between the two groups.

BIOMED RESEARCH INTERNATIONAL (2022)

Article Microbiology

Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance

Laura A. Doorley et al.

Summary: Candida parapsilosis is a common cause of invasive candidiasis worldwide, particularly in pediatric and neonatal populations. A study found that nonsynonymous mutations in the CpMRR1 gene are important genetic determinants of fluconazole resistance in clinical isolates of C. parapsilosis, primarily driven by upregulation of MFS and ABC transporters.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Article Microbiology

Evidence of Fluconazole-Resistant Candida parapsilosis Genotypes Spreading across Hospitals Located in Madrid, Spain and Harboring the Y132F ERG11p Substitution

Judith Diaz-Garcia et al.

Summary: This study monitored antifungal resistance in Candida parapsilosis isolates from inpatients at hospitals in the Madrid metropolitan area over a three-year period. The findings reveal the spread of fluconazole-resistant genotypes of C. parapsilosis across multiple hospitals in Madrid, Spain.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Review Infectious Diseases

Invasive Candidiasis: Update and Current Challenges in the Management of This Mycosis in South America

Fernando Oscar Riera et al.

Summary: Invasive candidiasis, caused by Candida species, is a persistent health problem with high morbidity and mortality rates. The distribution, diagnosis, treatment, and mortality of these infections vary worldwide. South America has a high mortality rate, with Candida albicans being the most prevalent species. However, there has been a global shift towards non-albicans species. This article summarizes the pathogenesis, immune response, and genetic factors affecting susceptibility to candidemia, as well as discussing treatment and future challenges, specifically in South America.

ANTIBIOTICS-BASEL (2022)

Article Microbiology

Characteristics of Biofilms Formed by C. parapsilosis Causing an Outbreak in a Neonatal Intensive Care Unit

Atsushi Miyake et al.

Summary: This study investigates the transmission route and biofilm of Candida parapsilosis in a neonatal intensive care unit (NICU). Microsatellite analysis confirms that the C. parapsilosis strains in the three inpatients and two environmental cultures are the same. Dry weight measurements and electron microscopy confirm the formation of biofilms by C. parapsilosis. The outbreak is attributed to horizontal transfer through the incubator's humidifier, and the biofilm produced by C. parapsilosis is linked to its invasive and infectious properties.

JOURNAL OF FUNGI (2022)

Article Chemistry, Applied

Bifunctional Dalteparin/Enoxaparin coated nanosilver formulation to prevent bloodstream infections during hemodialysis

Mukesh Kumar Meher et al.

Summary: Catheter-related bloodstream infections are a major concern for hemodialysis patients. A study has developed a low molecular weight heparin coated nanosilver with dual functions as an anticoagulant and antimicrobial/anti-biofilm agent. The heparinized nanosilver showed good blood compatibility and strong inhibitory/eradicating effects on microbial biofilms.

CARBOHYDRATE POLYMERS (2022)

Article Public, Environmental & Occupational Health

Role of the environment in transmission of Gram-negative bacteria in two consecutive outbreaks in a haematology-oncology department

W. C. van der Zwet et al.

Summary: This article reports two outbreaks of drug-resistant bacterial infections in the haematology-oncology department in 2019-2020, and highlights the importance of biofilms in the drainage system as a potential source of nosocomial transmission of Gram-negative bacteria.

INFECTION PREVENTION IN PRACTICE (2022)

Article Peripheral Vascular Disease

The microbial biofilm composition on peripherally inserted central catheters: A comparison of polyurethane and hydrophobic catheters collected from paediatric patients

Maddie Higgins et al.

Summary: This study investigated the microbial biofilm composition in peripherally inserted central catheters and found complex microbial communities in both traditional polyurethane and hydrophobic catheters. A higher diversity of pathogens was observed on the colonised catheter from a patient with central line-associated bloodstream infection. The diversity of microbial communities appeared to decrease significantly with dwell time, regardless of the catheter biomaterial design or antibiotic therapy.

JOURNAL OF VASCULAR ACCESS (2021)

Article Infectious Diseases

Uncovering the novel Enterobacter cloacae complex species responsible for septic shock deaths in newborns: a cohort study

Delphine Girlich et al.

Summary: This study analyzed the transmission routes of Enterobacter cloacae complex isolates in a neonatal intensive care unit using whole genome sequencing, revealing the impact of E cloacae on fatal septic shocks in neonates and the role of incubators as long-term reservoirs and sources of cross contamination.

LANCET MICROBE (2021)

Article Immunology

Prevention of Central-Line Associated Bloodstream Infections: 2021 Update

Laura M. Selby et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2021)

Article Biotechnology & Applied Microbiology

Effect of LongZhang Gargle on Dual-Species Biofilm of Candida albicans and Streptococcus mutans

Jinglei Gong et al.

Summary: LongZhang Gargle was found to significantly reduce biofilm biomass, cell activity, and formation of hyphae in single and dual-species biofilms of Candida albicans and Streptococcus mutans. However, it did not affect the production of Extracellular polysaccharides (EPS). It shows promise as a natural drug for treating oral diseases caused by these pathogens.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Immunology

Characteristics, Risk Factors and Predictors for Candidemia in the Pediatric Intensive Care Unit at the University Hospital Centre Zagreb in Croatia A 9-Year Retrospective Study

Toni Matic et al.

Summary: Candidemia in the PICU setting is mainly caused by Candida parapsilosis and is associated with risk factors such as the use of multiple antibiotics, previous bacterial infections, and prolonged PICU stay. A proposed predictive scoring system showed high sensitivity and specificity in identifying patients at risk of candidemia, suggesting potential benefits of prophylactic antifungal therapy.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2021)

Article Multidisciplinary Sciences

Effects of lipid emulsions on the formation of Escherichia coli-Candida albicans mixed-species biofilms on PVC

Shanshan Li et al.

Summary: Lipid emulsions can enhance the formation of E. coli-C. albicans mixed-species biofilms, especially at a concentration of 10%. The mechanism by which lipid emulsions promote mixed-species biofilm formation may involve the significant upregulation of genes associated with bacterial motility, adhesion, and biofilm formation.

SCIENTIFIC REPORTS (2021)

Article Public, Environmental & Occupational Health

Risk Factors of Candida parapsilosis Catheter-Related Bloodstream Infection

Dina Hussein Yamin et al.

Summary: Catheter-related bloodstream infection, caused by various nosocomial pathogens, is an important healthcare-associated infection, with Candida parapsilosis emerging as a crucial causative agent in the last two decades. Factors such as ICU admission were found to be significantly associated with non-CRBSI, while TPN was significantly positively associated with CRBSI. Patients admitted in ICU were less likely to develop C. parapsilosis CRBSI, while patients receiving TPN were more likely to have C. parapsilosis CRBSI compared to the non-CRBSI group.

FRONTIERS IN PUBLIC HEALTH (2021)

Article Infectious Diseases

A genetic cluster of MDR Enterobacter cloacae complex ST78 harbouring a plasmid containing blaVIM-1 and mcr-9 in the Netherlands

Antoni P. A. Hendrickx et al.

Summary: The genetic cluster of Enterobacter cloacae complex isolates collected in Dutch national surveillance from 2015-20 revealed a lineage producing carbapenemase, carrying multiple antibiotic resistance genes. The EclCluster-013 isolates, originating from three different hospitals in the Netherlands, belonged to the globally disseminated ST78 lineage and carried an IncH12 plasmid containing bla(VIM-1) carbapenemase and the novel mcr-9 colistin resistance gene. These MDR strains were susceptible to meropenem and colistin.

JAC-ANTIMICROBIAL RESISTANCE (2021)

Article Microbiology

Lack of efficacy of echinocandins against high metabolic activity biofilms of Candida parapsilosis clinical isolates

Danilo Yamamoto Thomaz et al.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2020)

Review Immunology

Do Mixed-Species Biofilms Dominate in Chronic Infections?-Need forin situVisualization of Bacterial Organization

Lasse Kvich et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Microbiology

Candida parapsilosis: from Genes to the Bedside

Renata Toth et al.

CLINICAL MICROBIOLOGY REVIEWS (2019)

Article Biochemistry & Molecular Biology

Biofilm-Forming by Carbapenem Resistant Enterobacteriaceae May Contribute to the Blood Stream Infection

Kenichiro Yaita et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Otorhinolaryngology

Prospective observational study of adenoidal biofilms in a paediatric population and their clinical implications

Joao Subtil et al.

POLISH JOURNAL OF OTOLARYNGOLOGY (2019)

Review Infectious Diseases

Biofilm-related disease

Jose Luis Del Pozo

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2018)

Article Multidisciplinary Sciences

Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection

Niladri Bhusan Pati et al.

SCIENTIFIC REPORTS (2018)

Article Microbiology

Enterobacter bugandensis sp nov., isolated from neonatal blood

Swapnil Doijad et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2016)

Article Microbiology

Implication of Candida parapsilosis FKS1 and FKS2 Mutations in Reduced Echinocandin Susceptibility

M. Marti-Carrizosa et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Article Biochemical Research Methods

Prokka: rapid prokaryotic genome annotation

Torsten Seemann

BIOINFORMATICS (2014)

Article Infectious Diseases

Is Biofilm Production a Predictor of Catheter-Related Candidemia?

Maria Guembe et al.

MEDICAL MYCOLOGY (2014)

Article Microbiology

Streptococcus mutans, Candida albicans, and the Human Mouth: A Sticky Situation

Khalid H. Metwalli et al.

PLOS PATHOGENS (2013)

Article Infectious Diseases

Impact of nosocomial polymicrobial bloodstream infections on the outcome in critically ill patients

S. Sancho et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2012)

Review Biochemistry & Molecular Biology

Importance of Candida-bacterial polymicrobial biofilms in disease

Melphine M. Herriott et al.

TRENDS IN MICROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

VFDB: a reference database for bacterial virulence factors

LH Chen et al.

NUCLEIC ACIDS RESEARCH (2005)

Review Biochemistry & Molecular Biology

Bacterial coaggregation: an integral process in the development of multi-species biofilms

AH Rickard et al.

TRENDS IN MICROBIOLOGY (2003)

Article Microbiology

Fluorescent in situ hybridization allows rapid identification of microorganisms in blood cultures

VAJ Kempf et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2000)