期刊
FOODS
卷 11, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/foods11193101
关键词
Panax notoginseng; polysaccharide; structure; hypoglycemic effects
资金
- Fundamental Research Funds for the Central Universities of Southwest Minzu University [2021HQZZ08]
- Open Project Program of the Key Laboratory of Brewing Molecular Engineering of China Light Industry [BME-202201]
- National Natural Science Foundation of China [32001675]
The study investigated the structural features and hypoglycemic effects of a polysaccharide Pan from the root of Panax notoginseng. The results showed that Pan had good antioxidant activity and could slow down body weight and blood glucose content in high-fat diet-induced mice. It further suppressed the expression of certain substances in the intestines and enhanced the expression of certain substances in the liver, exhibiting hypoglycemic effects.
In the study, the structural features and hypoglycemic effects of a polysaccharide Pan from the root of Panax notoginseng were investigated. The molecular weight of Pan was 8.27 kDa. Structural analysis indicated that Pan mainly consisted of -> 3)-beta-L-Rhap-(1 ->, -> 3,6)-beta-D-Galf-(1 -> and -> 6)-beta-D-Galf-(1 -> residues with acetyl groups. Pan exhibited good antioxidant activity. Pan could slow down the body weight and the content of blood glucose in the high-fat diet-induced mice, further suppress GLUT-2 and SGLT-1 expression in the intestines, and enhance p-IRS and p-AMPK expression in the livers, finally exhibiting hypoglycemic effects. The results could supply a direction for further research on polysaccharides as components for the control of hyperglycemia induced by obesity and diabetes.
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