Hypoglycemic Effects of Novel Panax notoginseng Polysaccharide in Mice with Diet-Induced Obesity

In the study, the structural features and hypoglycemic effects of a polysaccharide Pan from the root of Panax notoginseng were investigated. The molecular weight of Pan was 8.27 kDa. Structural analysis indicated that Pan mainly consisted of -> 3)-beta-L-Rhap-(1 ->, -> 3,6)-beta-D-Galf-(1 -> and -> 6)-beta-D-Galf-(1 -> residues with acetyl groups. Pan exhibited good antioxidant activity. Pan could slow down the body weight and the content of blood glucose in the high-fat diet-induced mice, further suppress GLUT-2 and SGLT-1 expression in the intestines, and enhance p-IRS and p-AMPK expression in the livers, finally exhibiting hypoglycemic effects. The results could supply a direction for further research on polysaccharides as components for the control of hyperglycemia induced by obesity and diabetes.

Automated summary

The study investigated the structural features and hypoglycemic effects of a polysaccharide Pan from the root of Panax notoginseng. The results showed that Pan had good antioxidant activity and could slow down body weight and blood glucose content in high-fat diet-induced mice. It further suppressed the expression of certain substances in the intestines and enhanced the expression of certain substances in the liver, exhibiting hypoglycemic effects.