期刊
FOODS
卷 11, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/foods11172673
关键词
ethanolic extract; shrimp shells; liposome; amyloid-beta; memory impairment
资金
- Prince of Songkla University [PHD/0182/2561]
- [SCI6302138S]
This study found that the ethanolic extract-loaded liposome from white shrimp shells had neuroprotective effects on Aβ-induced memory impairment in rats. It improved memory ability through the regulation of memory-related proteins and activation of signaling pathways.
Alzheimer's disease is characterized by a progressive loss of memory and cognition. Accumulation of amyloid-beta (A beta) in the brain is a well-known pathological hallmark of the disease. In this study, the ethanolic extract of white shrimp (Litopenaous vannamei) shells and the ethanolic extract-loaded liposome were tested for the neuroprotective effects on A beta(1-42)-induced memory impairment in rats. The commercial astaxanthin was used as a control. Treatment with the ethanolic extract of shrimp shells (EESS) at the dose of 100 mg/kg BW showed no protective effect in A beta-treated rats. However, treatment with an EESS-loaded liposome at the dose of 100 mg/kg BW significantly improved memory ability in Morris water maze and object recognition tests. The beneficial effect of the EESS-loaded liposome was ensured by the increase of the memory-related proteins including BDNF/TrkB and pre- and post-synaptic protein markers GAP-43 and PSD-95 as well as pErk1/2/Erk1/2 in the cortex and hippocampus. These findings indicated the neuroprotective effects of the EESS-loaded liposome on A beta-induced memory impairment in rats. It produced beneficial effects on learning behavior probably through the function of BDNF/TrkB/pErk1/2/Erk1/2 signaling pathway and subsequently the upregulation of synaptic proteins. The present study provided evidence that the neuroprotective property of the ESSE-loaded liposome could be a promising strategy for AD protection.
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