4.7 Article

Effect of Coffee on the Bioavailability of Sterols

期刊

FOODS
卷 11, 期 19, 页码 -

出版社

MDPI
DOI: 10.3390/foods11192935

关键词

cholesterol; bile salts; coffee; hypocholesterolemic; permeability; Caco-2 monolayers; dehydroergosterol

资金

  1. Fundacao para a Ciencia e a Tecnologia (FCT)/MCTES [FCT UID/QUI/00062/2019, UIDB/50006/2020, UIDB/00313/2020, UIDP/00313/2020]
  2. national funds (OE) [PTDC/QUI-OUT/29373/2017, POCI 01-0145-FEDER-031032]
  3. Operational Program of Competitiveness and Internationalization (POCI), within the PT2020 Partnership Agreement
  4. FCT [SFRH/BD/138873/2018]
  5. LAQV-REQUIMTE [UIDB/50006/2020]
  6. FEDER

向作者/读者索取更多资源

This study evaluated the effects of coffee with different commercial roasting and grinding levels on cholesterol absorption. It was found that coffee extracts can decrease the permeability coefficient of cholesterol and affect its bioavailability through increased cholesterol precipitation. Dark roasting and finer grinding of coffee showed stronger hypocholesterolemic effects.
Absorption at the intestinal epithelium is a major determinant of cholesterol levels in the organism, influencing the entry of dietary cholesterol and the excretion of endogenous cholesterol. Several strategies are currently being followed to reduce cholesterol absorption, using both pharmacological agents or food ingredients with hypocholesterolemic properties. Coffee has recently been shown to affect cholesterol bioaccessibility, although it has not been shown if this translates into a decrease on cholesterol bioavailability. In this work, coffee obtained with different commercial roasting (light and dark) and grinding (finer and coarser) was evaluated regarding their effect on cholesterol absorption through Caco-2 monolayers, mimicking the intestinal epithelium. The fluorescent dehydroergosterol was used as a sterol model, which was shown to permeate Caco-2 monolayers with a low-to-moderate permeability coefficient depending on its concentration. In the presence of coffee extracts, a 50% decrease of the sterol permeability coefficient was observed, showing their potential to affect sterol bioavailability. This was attributed to an increased sterol precipitation and its deposition on the apical epithelial surface. A higher hypocholesterolemic effect was observed for the dark roasting and finer grinding, showing that the modulation of these technological processing parameters may produce coffees with optimized hypocholesterolemic activity.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据