Antiplatelet therapy for patients with COVID-19: Systematic review and meta-analysis of observational studies and randomized controlled trials

Review Infectious Diseases

Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review

Thibault Fiolet et al.

Summary: Overall, COVID-19 vaccines have high efficacy against the original strain and variants of concern, with rare serious adverse events. However, prices vary significantly for different vaccines.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Cardiac & Cardiovascular Systems

Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry

Francesco Santoro et al.

Summary: This study suggests that antiplatelet therapy (APT) during hospitalization for COVID-19 may be associated with lower mortality risk and shorter duration of mechanical ventilation without increased risk of bleeding.

HEART (2022)

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Editorial Material Cardiac & Cardiovascular Systems

Further evidence for the use of aspirin in COVID-19

Udaya S. Tantry et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2022)

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Article Medicine, General & Internal

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19 A Randomized Clinical Trial

Jeffrey S. Berger et al.

Summary: Adding a P2Y12 inhibitor to anticoagulant therapy did not result in improved organ support-free days in non-critically ill COVID-19 patients hospitalized for COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Editorial Material Hematology

Shining a light on platelet activation in COVID-19

Frederik Denorme et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Medicine, General & Internal

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Peter W. Horby et al.

Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.

LANCET (2022)

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Article Cardiac & Cardiovascular Systems

Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

Diana A. Gorog et al.

Summary: COVID-19 predisposes patients to thrombotic and thromboembolic events. Numerous biomarkers have emerged to assess the thrombotic risk in these patients, informing prognosis and predicting thrombosis.

NATURE REVIEWS CARDIOLOGY (2022)

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Review Pharmacology & Pharmacy

Thromboinflammation in coronavirus disease 2019: The clot thickens

Raayma Iffah et al.

Summary: The pathophysiology of COVID-19 is complex, with multiple systems contributing to thrombosis and inflammation. Understanding the role of the immune system in different patient cohorts is crucial for developing novel therapeutic targets and drug repurposing strategies.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

David J. Ahern et al.

Summary: The study presents a comprehensive blood atlas for patients with varying severity of COVID-19, compared to influenza, sepsis patients, and healthy volunteers. The results identify immune signatures and correlates of host response, including cells, inflammatory mediators, immune repertoire, and metabolic and coagulation features. The study also reveals that persistent immune activation is a specific feature of COVID-19. Plasma proteomic analysis enables sub-phenotyping and prediction of severity and outcome. Integrative analyses show feature groupings linked with severity and specificity compared to influenza and sepsis.

CELL (2022)

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Article Medicine, General & Internal

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19 A Randomized Clinical Trial

Charlotte A. Bradbury et al.

Summary: The study results showed that among critically ill patients with COVID-19, treatment with an antiplatelet agent compared with no antiplatelet agent did not significantly improve the number of organ support-free days within 21 days. The use of antiplatelet therapy in critically ill patients with COVID-19 did not show significant benefits.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Article Cardiac & Cardiovascular Systems

Impact of pre-admission antithrombotic therapy on disease severity and mortality in patients hospitalized for COVID-19

Mariana Corrochano et al.

Summary: The study found that chronic anticoagulation therapy prior to hospitalization for COVID-19 was associated with lower ICU admission rates, but there were no significant differences in mortality between the patients receiving chronic antithrombotic therapy and patients not taking antithrombotic medications.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)

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Review Microbiology

SARS-CoV-2 pathogenesis

Mart M. Lamers et al.

Summary: This Review explores the recent clinical and experimental advancements in understanding the pathogenesis of SARS-CoV-2, its interactions with host cells, and the role of the immune system in the development of severe disease, with a focus on the mechanisms underlying COVID-19-associated ARDS. The findings suggest that SARS-CoV-2 can infect the lower respiratory tract, causing alveolar damage and dysfunctional immune responses, leading to inflammation and immunopathology. These insights may contribute to the development of new therapeutic interventions against COVID-19.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Hematology

Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells

Florian Puhm et al.

Summary: Platelets are hyperactivated in COVID-19, but the mechanisms behind platelet activation by SARS-CoV-2 are not well understood. This study found that tissue factor (TF) produced by infected cells can activate platelets. Virions and extracellular vesicles (EVs) were also identified, and TF activity was associated with either the virus or the EVs. Blocking this pathway may interfere with platelet activation and the coagulation characteristics of COVID-19.

BLOOD ADVANCES (2022)

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Article Hematology

Thromboprophylaxis in COVID-19: Weight and severity adjusted intensified dosing

Matthias M. Engelen et al.

Summary: After implementing a hospital-wide intensified thromboprophylactic protocol for COVID-19 hospitalized patients, there were no additional symptomatic VTE cases, and a reduction in incidental deep vein thrombosis was observed, along with a lower risk of major bleeding.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2022)

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Review Hematology

Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system

Maria Grazia Lazzaroni et al.

Summary: COVID-19 is a new pandemic caused by SARS-Cov2 infection, with inflammation and the innate immune system playing key roles in the most severe cases. Abnormalities in coagulation parameters and platelets count have been reported, suggesting a subgroup of patients with poor prognosis. The cytokine storm and virus-specific mechanisms may also contribute to adverse outcomes in COVID-19.

BLOOD REVIEWS (2021)

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Article Cell Biology

Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex

Aaron C. Petrey et al.

Summary: This study aims to identify pathogenic factors linked to disease severity and patient characteristics in COVID-19 patients. 16 soluble factors were found to be increased, 2 decreased, with key factors associated with severe disease and ICU admission. Levels of IL-4 and sCD40L were higher in males, and analysis revealed associations between disease severity, sex, and biomarkers.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Review Medical Laboratory Technology

Thrombocytopenia Is Associated with COVID-19 Severity and Outcome: An Updated Meta-Analysis of 5637 Patients with Multiple Outcomes

Xiaolong Zong et al.

Summary: Approximately 12% of hospitalized COVID-19 patients have thrombocytopenia (TCP), which is associated with more severe illness and poor outcomes. Patients with TCP are at a higher risk of progressing to acute respiratory distress syndrome and mortality, with the risk increased threefold.

LABORATORY MEDICINE (2021)

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Review Cell Biology

Immunothrombosis and thromboinflammation in host defense and disease

Kimberly Martinod et al.

Summary: Platelets play roles beyond thrombosis and hemostasis by mediating inflammation through direct interactions with immune cells and secretion of cytokines/chemokines. They interact with neutrophils and monocytes/macrophages in infections, sepsis, stroke, myocardial infarctions, and venous thromboembolisms, while also contributing to the formation of neutrophil extracellular traps (NETs) and deep vein thrombosis during infections like in COVID-19 patients.

PLATELETS (2021)

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Article Anesthesiology

Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study

Xu Zhao et al.

Summary: This study found that the use of apixaban, enoxaparin, or aspirin was independently associated with lower mortality in critically ill COVID-19 patients, likely due to the hypercoagulability in severe COVID-19.

ANESTHESIOLOGY (2021)

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Article Hematology

Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysis

Matthew L. Meizlish et al.

Summary: In this study of hospitalized COVID-19 patients, intermediate-dose anticoagulation and aspirin treatment were each associated with a significantly lower cumulative incidence of in-hospital death as shown by propensity score matching and multivariable regression analysis.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Impact of oral anticoagulation on clinical outcomes of COVID-19: a nationwide cohort study of hospitalized patients in Germany

Georg M. Froehlich et al.

Summary: This study investigated the impact of concomitant long-term medication on clinical outcomes in hospitalized COVID-19 patients. The use of oral anticoagulants was associated with improved outcomes, while ACE inhibitors did not impact outcomes. Prospective randomized trials are needed to verify these findings.

CLINICAL RESEARCH IN CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

Sean X. Gu et al.

Summary: Platelet and endothelial dysfunction are essential components of COVID-19 pathology, while cardiovascular risk factors exacerbate the severity of the disease. Patients with pre-existing cardiovascular disease and risk factors are at the highest risk of death from COVID-19.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Pre-admission acetylsalicylic acid therapy and impact on in-hospital outcome in COVID-19 patients: The ASA-CARE study

Antonio Sisinni et al.

Summary: In a cohort study of 984 hospitalized COVID-19 patients, pre-admission treatment with low-dose aspirin was associated with better in-hospital outcomes, mainly driven by a reduction in the need for respiratory support upgrade.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Medicine, General & Internal

Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19 The ACTIV-4B Randomized Clinical Trial

Jean M. Connors et al.

Summary: This study aimed to assess the impact of anticoagulant or antiplatelet therapy on symptomatic clinically stable outpatients with COVID-19. The results showed that treatment with aspirin or apixaban compared with placebo did not reduce the rate of a composite clinical outcome, and the study was terminated early due to a lower than anticipated event rate.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Endocrinology & Metabolism

Adverse outcomes in COVID-19 and diabetes: a retrospective cohort study from three London teaching hospitals

Chioma Izzi-Engbeaya et al.

Summary: Patients with diabetes mellitus admitted to hospital with COVID-19 have poorer outcomes, with factors such as male gender, advancing age, lower platelet count, and higher Clinical Frailty Scale (CFS) score independently predicting poor outcomes. Antiplatelet medication was associated with a lower risk of death/ICU admission. Comorbidities such as diabetes with ischemic heart disease were major determinants of poor outcomes in COVID-19 patients.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

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Article Biochemistry & Molecular Biology

The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection

Eugene Merzon et al.

Summary: The study observed a negative association between the use of aspirin and COVID-19 infection, disease duration, and mortality. Aspirin users were typically older, had lower BMI, and higher rates of conditions like hypertension and diabetes compared to non-users.

FEBS JOURNAL (2021)

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Review Hematology

Platelet FcγRIIA in immunity and thrombosis: Adaptive immunothrombosis

Pravin Patel et al.

Summary: In the past decade, there has been a greater recognition of the role of platelets in host defense, specifically in immunity and thrombosis. Platelets are the first responders in the blood to both microbial and non-microbial antigens. They play a dual role in physiologic immunity and pathology, such as microvascular thrombosis.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Cardiac & Cardiovascular Systems

Association of chronic anticoagulant and antiplatelet use on disease severity in SARS-COV-2 infected patients

Gwendolyn Ho et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Medicine, General & Internal

Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19

Qiang Liu et al.

Summary: In a study involving adults infected with SARS-Cov-2, it was found that patients using low-dose aspirin (100 mg/day) had significantly lower 30-day and 60-day mortality rates compared to those not using aspirin, although there was no significant difference in viral duration between the two groups.

MEDICINE (2021)

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Article Multidisciplinary Sciences

Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration

Thomas F. Osborne et al.

Summary: The study found that pre-diagnosis aspirin prescription was significantly associated with decreased mortality rates for COVID-19 positive Veterans, indicating the potential benefits of aspirin for patients with COVID-19.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Aakriti Gupta et al.

Summary: The use of statins in patients hospitalized with COVID-19 is associated with a lower risk of inpatient mortality, potentially due to their anti-inflammatory and antithrombotic properties.

NATURE COMMUNICATIONS (2021)

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Review Infectious Diseases

Active prescription of low-dose aspirin during or prior to hospitalization and mortality in COVID-19: A systematic review and meta-analysis of adjusted effect estimates

Januar Wibawa Martha et al.

Summary: This study found that the use of low-dose aspirin is independently associated with reduced mortality in patients with COVID-19. There was also a significant reduction in mortality for patients receiving low-dose aspirin during hospitalization. The included studies had low-to-moderate risk of bias.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Virology

Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19

Mohammad Haji Aghajani et al.

Summary: The use of aspirin in hospitalized patients with COVID-19 is significantly associated with a decrease in mortality rate, suggesting a potential benefit of aspirin add-on therapy in severe cases. Further prospective randomized controlled trials are needed to confirm the efficacy and safety of aspirin administration in this patient population.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Letter Cardiac & Cardiovascular Systems

Use of antiplatelet drugs and the risk of mortality in patients with COVID-19: a meta-analysis

Chia Siang Kow et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Article Cardiac & Cardiovascular Systems

Association between cardiovascular disease, cardiovascular drug therapy, and in-hospital outcomes in patients with COVID-19: data from a large single-center registry in Poland

Michal Terlecki et al.

Summary: The study found that patients with COVID-19 who have cardiovascular diseases, such as heart failure and diabetes mellitus, have an increased in-hospital mortality rate. However, the use of cardiovascular drugs, such as ACEIs/ARBs, beta-blockers, statins, or antiplatelet therapy, is associated with a decreased risk of death.

KARDIOLOGIA POLSKA (2021)

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Article Peripheral Vascular Disease

Effect of aspirin on short-term outcomes in hospitalized patients with COVID-19

Aditya Sahai et al.

Summary: The study found that aspirin and NSAIDs did not affect mortality rates or prevent thrombosis in patients with COVID-19. Further investigation is needed to understand the mechanisms of thrombosis in COVID-19 and the role of platelets in mediating this process.

VASCULAR MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Combined anticoagulant and antiplatelet therapy is associated with an improved outcome in hospitalised patients with COVID-19: a propensity matched cohort study

Kamal Matli et al.

Summary: This study found that using therapeutic anticoagulation (TAC) or a combination of antiplatelet and anticoagulants in hospitalized patients with COVID-19 was associated with improved outcomes compared to prophylactic anticoagulation alone. Further research is needed to confirm these findings.

OPEN HEART (2021)

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Article Endocrinology & Metabolism

Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus

Christina Kohlmorgen et al.

Summary: The study investigated the effect of SGLT2i dapagliflozin on platelet activation and inflammation in atherogenesis. Results showed that dapagliflozin treatment reduced atherosclerotic lesion development, circulating platelet-leucocyte aggregates, and aortic macrophage infiltration. Additionally, dapagliflozin decreased platelet activation and thrombin generation without affecting bleeding time.

DIABETOLOGIA (2021)

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Article Cardiac & Cardiovascular Systems

Pre-hospital antiplatelet medication use on COVID-19 disease severity

Darren Pan et al.

Summary: This study aimed to investigate the relationship between pre-hospitalization antiplatelet medication use and COVID-19 disease severity. The results showed that after adjusting for covariates, there was no association between pre-hospital antiplatelet use and the severity of COVID-19 in hospitalized patients.

HEART & LUNG (2021)

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Article Medicine, General & Internal

Use of aspirin in reduction of mortality of COVID-19 patients: A meta-analysis

Ritika Srivastava et al.

Summary: Aspirin may have a role in reducing mortality in COVID-19 patients, but further clinical evidence is needed to draw a valid conclusion. The meta-analysis showed a lower likelihood of death in the aspirin group compared to the non-aspirin group, although the effect changed after excluding outliers.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Article Infectious Diseases

Drug exposure may have a substantial influence on COVID-19 prognosis among residents of long-term care facilities: an exploratory analysis

Laura Soldevila et al.

Summary: The study explored the association between drug exposure and SARS-CoV-2 prognosis among elderly individuals in LTC facilities. Findings showed that inhaled corticoids and statins intake were protective factors against death, with a near significant association for ACE2 inhibitors. Drug exposure may play a crucial role in modifying Covid-19 outcomes in LTC residents.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Immunology

Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education

Jan Rossaint et al.

Summary: Platelets play a crucial role in immune cell recruitment and host defense in addition to hemostasis. They form aggregates with regulatory T cells in the lung during inflammation, facilitating the release of anti-inflammatory mediators and reprogramming of macrophages for an effective resolution of pulmonary inflammation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Hematology

Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis

Jonathan H. Chow et al.

Summary: A large observational study of COVID-19 patients found that prehospital antiplatelet therapy was associated with significantly lower in-hospital mortality. The study suggests that further randomized controlled trials are needed to determine the ultimate utility of antiplatelet therapy in COVID-19 patients with high rates of comorbidities.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Patrick R. Lawler et al.

Summary: This study showed that therapeutic-dose anticoagulation with heparin in non-critically ill patients with Covid-19 increased the likelihood of survival to hospital discharge and reduced the need for cardiovascular or respiratory organ support compared to usual-care thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Ewan C. Goligher et al.

Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Hematology

Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use

Faruk Aydinyilmaz et al.

Summary: The study found associations between MPV, RDW, D-Dimer, and mortality in COVID-19 patients. Patients with MPV >10.45 f/l and D-Dimer >500.2 ng/mL who received treatment with ASA had lower mortality rates in the ICU setting.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Article Immunology

Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape

John S. Tregoning et al.

Summary: The development and rollout of vaccines have brought hope for controlling the COVID-19 pandemic, with vaccines proving highly effective in preventing disease. However, challenges remain in ensuring equitable access to vaccines globally, as well as lessons to be learned for controlling pandemics in the future.

NATURE REVIEWS IMMUNOLOGY (2021)

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Letter Biochemistry & Molecular Biology

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

Cameron Mura et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Health Care Sciences & Services

Meta-analyses frequently pooled different study types together: a meta-epidemiological study

Rene-Sosata Bun et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2020)

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Article Hematology

Impact of anticoagulation prior to COVID-19 infection: a propensity score-matched cohort study

Douglas Tremblay et al.

BLOOD (2020)

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Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

CELL (2020)

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Review Hematology

Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

Behnood Bikdeli et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Review Cardiac & Cardiovascular Systems

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow

Behnood Bikdeli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Pharmacology & Pharmacy

Clinical impact of pre-admission antithrombotic therapy in hospitalized patients with COVID-19: A multicenter observational study

Vincenzo Russo et al.

PHARMACOLOGICAL RESEARCH (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Can an Old Ally Defeat a New Enemy?

Paul A. Gurbel et al.

CIRCULATION (2020)

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Letter Cardiac & Cardiovascular Systems

Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease

Tessa J. Barrett et al.

CIRCULATION RESEARCH (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Article Hematology

Platelet gene expression and function in patients with COVID-19

Bhanu Kanth Manne et al.

BLOOD (2020)

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Article Hematology

Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment

Yuncheng Man et al.

BLOOD CELLS MOLECULES AND DISEASES (2020)

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Article Hematology

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

George Goshua et al.

LANCET HAEMATOLOGY (2020)

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Article Medicine, General & Internal

Vascular occlusion by neutrophil extracellular traps in COVID-19

Moritz Leppkes et al.

EBIOMEDICINE (2020)

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Article Hematology

Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia

Francesco Taus et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

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Article Cardiac & Cardiovascular Systems

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Younes Zaid et al.

CIRCULATION RESEARCH (2020)

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Review Critical Care Medicine

The unique characteristics of COVID-19 coagulopathy

Toshiaki Iba et al.

CRITICAL CARE (2020)

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Article Multidisciplinary Sciences

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Jose Perdomo et al.

NATURE COMMUNICATIONS (2019)

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Review Cardiac & Cardiovascular Systems

Platelet biology and functions: new concepts and clinical perspectives

Paola E. J. van der Meijden et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Platelet Depletion Impairs Host Defense to Pulmonary Infection with Pseudomonas aeruginosa in Mice

Richard T. Amison et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Article Medicine, General & Internal

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

K. I. Ataga et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Multidisciplinary Sciences

Host DNases prevent vascular occlusion by neutrophil extracellular traps

Miguel Jimenez-Alcazar et al.

SCIENCE (2017)

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Article Hematology

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

Braedon McDonald et al.

BLOOD (2017)

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Review Physiology

PLATELETS IN PULMONARY IMMUNE RESPONSES AND INFLAMMATORY LUNG DISEASES

Elizabeth A. Middleton et al.

PHYSIOLOGICAL REVIEWS (2016)

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Article Hematology

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

Guadalupe Ortiz-Munoz et al.

BLOOD (2014)

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Editorial Material Medicine, General & Internal

Retrospective cohort studies: advantages and disadvantages

Philip Sedgwick

BMJ-BRITISH MEDICAL JOURNAL (2014)

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Review Medicine, General & Internal

Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials

Andrew Anglemyer et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2014)

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Article Medicine, General & Internal

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

David Moher et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

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Article Hematology

Combined antiplatelet and anticoagulant therapy: clinical benefits and risks

J. W. Eikelboom et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)

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Article Biochemistry & Molecular Biology

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Stephen R. Clark et al.

NATURE MEDICINE (2007)

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Letter Medicine, General & Internal

Observational versus randomised trial evidence

KT Khaw et al.

LANCET (2004)

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Article Medicine, General & Internal

Measuring inconsistency in meta-analyses

JPT Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2003)

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Antiplatelet therapy for patients with COVID-19: Systematic review and meta-analysis of observational studies and randomized controlled trials

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