期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 59, 期 5, 页码 2025-2040出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.5b01629
关键词
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资金
- Ministere de l'Enseignement Superieur et de la Recherche (MESR)
- European Union
- ANR [ANR-10-LABX-33]
How anti-Alzheimer's drug candidates that reduce amyloid 1-42 peptide fibrillization interact with the most neurotoxic species is far from being understood. We report herein the capacity of sugar-based peptidomimetics to inhibit both A beta(1-42) early oligomerization and fibrillization. A wide range of bio- and physicochemical techniques, such as a new capillary electrophoresis method, nuclear magnetic resonance, and surface plasmon resonance, were used to identify how these new molecules can delay the aggregation of A beta(1-42). We demonstrate that these molecules interact with soluble oligomers in order to maintain the presence of nontoxic monomers and to prevent fibrillization. These compounds totally suppress the toxicity of A beta(1-42) toward SH-SYSY neuroblastoma cells, even at substoichiometric concentrations. Furthermore, demonstration that the best molecule combines hydrophobic moieties, hydrogen bond donors and acceptors, ammonium groups, and a hydrophilic beta-sheet breaker element provides valuable insight for the future structure-based design of inhibitors of A beta(1-42) aggregation.
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