期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 59, 期 13, 页码 6012-6024出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.5b01975
关键词
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资金
- Caltech-City of Hope Biomedical Research Initiative
- AACR Thomas J. Bardos Science Education Award
- NIH [R01 DK019038, R01 CA176611]
Lanthanide complexes are of increasing importance in cancer diagnosis and therapy, owing to the versatile chemical and magnetic properties of the lanthanide-ion 4f electronic configuration. Following the first implementation of gadolinium(III)-based contrast agents in magnetic resonance imaging in the 1980s, lanthanide-based small molecules and nanomaterials have been investigated as cytotoxic agents and inhibitors, in photodynamic therapy, radiation therapy, drug/gene delivery, biosensing, and bioimaging. As the potential utility of lanthanides in these areas continues to increase, this timely review of current applications will be useful to medicinal chemists and other investigators interested in the latest developments and trends in this emerging field.
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