期刊
PATHOGENS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/pathogens11091005
关键词
Hepatitis C virus; miR-122; miR-122-independent replication; 5 ' untranslated region; viral tropism
类别
资金
- Canadian Institutes of Health Research (CIHR) [MOP-133458]
- Natural Science and Research council of Canada (NSERC) [RGPIN-201806335]
- University of Saskatchewan (CoMBRIDGE)
- University of Saskatchewan
- CanHepC Ph.D. Scholarship
This review explores the unique relationship between liver-specific microRNA miR-122 and Hepatitis C virus (HCV), as well as the role of miR-122 in the virus life cycle, viral tropism, and pathogenesis. The review also discusses the impact of anti-miR-122 therapy on viral replication and how viruses manipulate host factors during the initial stage of infection to establish a successful infection.
Despite the advancement in antiviral therapy, Hepatitis C remains a global health challenge and one of the leading causes of hepatitis related deaths worldwide. Hepatitis C virus, the causative agent, is a positive strand RNA virus that requires a liver specific microRNA called miR-122 for its replication. Unconventional to the canonical role of miRNAs in translation suppression by binding to 3'Untranslated Region (UTR) of messenger RNAs, miR-122 binds to two sites on the 5'UTR of viral genome and promotes viral propagation. In this review, we describe the unique relationship between the liver specific microRNA and HCV, the current knowledge on the mechanisms by which the virus uses miR-122 to promote the virus life cycle, and how miR-122 impacts viral tropism and pathogenesis. We will also discuss the use of anti-miR-122 therapy and its impact on viral evolution of miR-122-independent replication. This review further provides insight into how viruses manipulate host factors at the initial stage of infection to establish a successful infection.
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