期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2022.965753
关键词
hormones; dental implant; osseointegration; PTH; insulin
资金
- Center of Stomatology Affiliated to Huazhong University of Science and Technology
- Hubei Provincial Science Technology Department Key Research and Development Program Clinical Prevention and Treatment of Oral and Maxillofacial Deformities
- [2020BCA072]
This review comprehensively summarizes the application and mechanisms of hormones in implant osseointegration, and discusses their effects on the prognosis of implants. The results show that systemic hormones can regulate the osseointegration of oral implants through endogenous or exogenous drug-delivery methods.
As clusters of peptides or steroids capable of high-efficiency information transmission, hormones have been substantiated to coordinate metabolism, growth, development, and other physiological processes, especially in bone physiology and repair metabolism. In recent years, the application of hormones for implant osseointegration has become a research hotspot. Herein, we provide a comprehensive overview of the relevant reports on endogenous hormones and their corresponding supplementary preparations to explore the association between hormones and the prognosis of implants. We also discuss the effects and mechanisms of insulin, parathyroid hormone, melatonin, vitamin D, and growth hormone on osseointegration at the molecular and body levels to provide a foothold and guide future research on the systemic conditions that affect the implantation process and expand the relative contraindications of the implant, and the pre-and post-operative precautions. This review shows that systemic hormones can regulate the osseointegration of oral implants through endogenous or exogenous drug-delivery methods.
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