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It's all in the numbers: Cohesin stoichiometry

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Summary: The centromere is crucial for the accurate segregation of chromosomes during cell division. By studying the physical structure and proteins enriched in centromeric chromatin, we propose a mechanism for building tension between sister kinetochores, where the centromere is organized by loop-extruding proteins into a bottlebrush arrangement, enabling it to resist pulling forces during mitosis.

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