期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 59, 期 18, 页码 8221-8232出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.6b00144
关键词
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资金
- ANR
- DGA [ANR-12-ASTR-0024]
- Fondation pour la Recherche Medicale, FRM [DEA20090616230]
- DGA
- Conseil Regional d'Aquitaine
- ImmuPharma France
- ANRT
The synthesis of bioinspired unnatural backbones leading to foldamers can provide effective peptide mimics with improved properties in a physiological environment. This approach has been applied to the design of structural mimics of membrane active antimicrobial peptides (AMPs) for which activities in vitro have been reported. Yet activities and pharmacokinetic properties in vivo in animal models have remained largely unexplored. Here, we report helical oligourea AMP mimics that are active in vitro against bacterial forms of Bacillus anthracis encountered in vivo, as well as in vivo in inhalational and cutaneous mouse models of B. anthracis infection. The pharmacokinetic profile and the tissue distribution were investigated-by beta-radio imager whole-body mapping in mice. tow excretion and recovery of the native oligourea in the kidney following intravenous injection is consistent with high stability in vivo. Overall these results provide useful information that support future biomedical development of urea-based foldamer peptide mimics.
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