Viral Diagnosis of Hepatitis B and Delta: What We Know and What Is Still Required? Specific Focus on Low- and Middle-Income Countries

Editorial Material Gastroenterology & Hepatology

Rapid Point-of-Care Test for Hepatitis B Core-Related Antigen to Diagnose High Viral Load in Resource-Limited Settings

Y. U. S. U. K. E. Shimakawa et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

Article Medicine, Research & Experimental

Combination of IL-34 and AFP improves the diagnostic value during the development of HBV related hepatocellular carcinoma

Kehui Liu et al.

Summary: IL-34 is involved in host immunity regulated carcinogenesis and combined with AFP can improve the diagnostic value in HBV-HCC.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

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Article Pathology

Clinical utility of the 'Determine HBsAg' Point-of-Care Test for Diagnosis of Hepatitis B Surface Antigen in Africa

Amie Ceesay et al.

Summary: Chronic HBV infection is a major cause of morbidity and mortality in SSA, but the majority of patients are unaware of their infection status. Scaling up HBV screening programs in SSA is crucial to reduce disease burden, and inexpensive rapid POC tests are key to achieving this goal.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

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Article Virology

Performance of the cobas® HBV RNA automated investigational assay for the detection and quantification of circulating HBV RNA in chronic HBV patients

Caroline Scholtes et al.

Summary: This study evaluated the performance of an HBV RNA assay on the cobas(R) 6800/8800 systems and found that it is a high throughput, sensitive, and inclusive assay for monitoring antiviral treatment in patients with chronic hepatitis B.

JOURNAL OF CLINICAL VIROLOGY (2022)

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Review Virology

ASSURED-compliant point-of-care diagnostics for the detection of human viral infections

Mahdi Naseri et al.

Summary: Viral disease outbreaks pose a threat to global public health, emphasizing the need for affordable and accurate diagnostics. Point-of-care diagnostics are a valuable tool, especially in countries with inadequate healthcare systems. The future of diagnostics lies in creating tools that meet the ASSURED criteria and can provide rapid and precise results for viral infections.

REVIEWS IN MEDICAL VIROLOGY (2022)

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Article Virology

Alpha-Fetoprotein (AFP) and AFP-L3 Is Most Useful in Detection of Recurrence of Hepatocellular Carcinoma in Patients after Tumor Ablation and with Low AFP Level

Madison Force et al.

Summary: Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is a leading cause of mortality worldwide. HBV and HCV infection are still the major risk factors for HCC globally. The utility of AFP-L3% in identifying early, new or recurrent HCC prior to the presence of imaging findings is emphasized.

VIRUSES-BASEL (2022)

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Article Gastroenterology & Hepatology

A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

Anna Kramvis et al.

Summary: This article introduces the biomarkers of hepatitis B virus (HBV) and highlights the current challenges.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Review Biochemistry & Molecular Biology

A Historical Review of Military Medical Strategies for Fighting Infectious Diseases: From Battlefields to Global Health

Roberto Biselli et al.

Summary: The environmental conditions generated by war favor the spread of infectious diseases. Military medical researchers have made significant contributions to the discovery of disease-causing agents and the development of preventive vaccines. The collaboration between military and civilian medical sectors has become closer, especially in research on infectious disease prevention and disaster management.

BIOMEDICINES (2022)

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Article Virology

TREAT-B Algorithm for Treatment Eligibility Among Chronically Infected Hepatitis B Virus Persons in a Low and a High Endemic Region: A Potential Strategy Towards Virus Elimination by 2030

Hussein Mukasa Kafeero et al.

Summary: This study investigated the treatment eligibility of chronically infected HBV patients in low and high endemic regions using the TREAT-B algorithm. The results showed that 56.8% of the participants qualified for treatment. Participants from the low endemic region had significantly higher treatment eligibility than those from the high endemic region. Alcohol use and household contact with an HBV-infected person were significantly associated with treatment eligibility. AST, GGT, and total bilirubin were the liver-related parameters significantly associated with treatment eligibility.

FRONTIERS IN VIROLOGY (2022)

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Article Gastroenterology & Hepatology

Ultrasensitive Assay for Hepatitis B Core-Related Antigen Predicts Hepatocellular Carcinoma Incidences During Entecavir

Tetsuya Hosaka et al.

Summary: The study found that measuring HBcrAg using an ultrasensitive assay has a better potential for predicting the development of hepatocellular carcinoma in patients with chronic hepatitis B undergoing antiviral treatment.

HEPATOLOGY COMMUNICATIONS (2022)

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Article Virology

Rapid, random-access, and quantification of hepatitis B virus using the Cepheid Xpert HBV viral load assay

Ali M. Auzin et al.

Summary: High correlation was observed between the Roche Cobas HBV Viral Load tests and the Xpert HBV Viral Load Assay, enabling rapid, random access, and accurate HBV VL assessment. Results demonstrated a mean difference of -0.107 log and a standard deviation of 0.271 log, with only six samples exceeding a 0.5 log difference between the two assays.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Gastroenterology & Hepatology

A Focused Review on Recent Advances in the Diagnosis and Treatment of Viral Hepatitis

Wei Zhang et al.

Summary: The global burden of viral hepatitis is still substantial, particularly due to hepatitis B and C virus infections. However, it is feasible to end hepatitis epidemics using current tools and approaches. Effective vaccines are available for hepatitis A, B, and E, while new treatment regimens for chronic hepatitis C patients can achieve high cure rates.

GASTROENTEROLOGY RESEARCH (2021)

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Article Gastroenterology & Hepatology

Potential of ultra-highly sensitive immunoassays for hepatitis B surface and core-related antigens in patients with or without development of hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Fumitaka Suzuki et al.

Summary: This study revealed that patients who developed HCC after HBsAg seroclearance continued to have positive HBsAg or HBcrAg levels during follow-up. The levels of HBcrAg in the HCC group were significantly higher than in the non-HCC group, indicating that residual low viral antigen may predict HCC development.

HEPATOLOGY RESEARCH (2021)

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Article Immunology

Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection

Shao-Juan Wang et al.

Summary: In this study, a novel method for detecting HBeAg was developed with high sensitivity and specificity, able to detect HBeAg from various HBV genotypes without cross-reactivity with HBcAg. This new method could be useful in drug screening and clinical HBeAg detection.

EMERGING MICROBES & INFECTIONS (2021)

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Review Virology

Hepatitis D Review: Challenges for the Resource-Poor Setting

Alice U. Lee et al.

Summary: Hepatitis D is the smallest and most aggressive virus known to infect humans, requiring hepatitis B surface antigen for replication. Treatment options for hepatitis D have been limited, but a new therapy has been licensed in Europe, showing high response rates.

VIRUSES-BASEL (2021)

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Article Virology

A Rapid Point-of-Care Test for the Serodiagnosis of Hepatitis Delta Virus Infection

Florian A. Lempp et al.

Summary: Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus (HBV) that causes severe liver disease. A novel HDV rapid test has been developed in this study, which can detect antibodies against all known HDV genotypes and works robustly for a broad range of anti-HDV titers.

VIRUSES-BASEL (2021)

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Article Medicine, General & Internal

Multicenter Evaluation of the Cepheid Xpert® HBV Viral Load Test

Fabbio Marcuccilli et al.

Summary: The study demonstrates that the Xpert HBV Viral Load test shows good agreement with the CAP/CTM HBV V2.0 assay, making it suitable for monitoring and diagnosing patients with chronic HBV infection.

DIAGNOSTICS (2021)

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Article Infectious Diseases

Development and clinical validation of loop-mediated isothermal amplification (LAMP) assay to diagnose high HBV DNA levels in resource-limited settings

Jessica Vanhomwegen et al.

Summary: A simple, rapid, and inexpensive alternative to PCR, the HBV-LAMP assay, has been developed to diagnose high viraemia >= 200,000 IU/mL, which may help in identifying high-risk pregnant women in resource-limited countries to eliminate HBV mother-to-child transmission.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Gastroenterology & Hepatology

Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation

Takako Inoue et al.

Summary: A fully automated, novel high-sensitivity hepatitis B core-related antigen assay (iTACT-HBcrAg) has been developed for monitoring chronic hepatitis B (CHB) and for the early detection of HBV reactivation. The clinical performance of iTACT-HBcrAg was compared with other HBV markers, showing satisfactory analytical performance and potential as a general marker of disease progression and treatment response.

JOURNAL OF HEPATOLOGY (2021)

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Article Virology

Reliable quantification of plasma HDV RNA is of paramount importance for treatment monitoring: A European multicenter study

Evelyn Stelzl et al.

Summary: The study aimed to improve comparability of quantitative results reported by different laboratories using the same RoboGene HDV RNA Quantification Kit 2.0, by determining correction factors, detection limits, and accuracy of different protocols. Results showed a range of correction factors and limits of detection, with variations in accuracy for different protocols, highlighting the need for revalidation when modifying extraction and amplification/detection protocols.

JOURNAL OF CLINICAL VIROLOGY (2021)

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Review Gastroenterology & Hepatology

Covalently closed circular DNA: The ultimate therapeutic target for curing HBV infections

Maria Guadalupe Martinez et al.

Summary: Current antiviral therapies for chronic hepatitis B can improve patients' quality of life but do not cure infected hepatocytes. Complete HBV cure requires therapies targeting the cccDNA pool directly. New technologies aim to achieve non-cytolytic direct cccDNA targeting for cure.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Baseline HBV-DNA load plus AST/ALT ratio predicts prognosis of HBV-related hepatocellular carcinoma after hepatectomy: A multicentre study

Junyi Shen et al.

Summary: This study analyzed 1,940 HBV-related HCC patients who underwent hepatectomy and found that a risk classification based on baseline HBV-DNA load and AST/ALT ratio could effectively stratify patients into four types with distinguishable prognoses post-operatively. The classification was significantly associated with HCC recurrence and long-term survival, providing important insights for patient management.

JOURNAL OF VIRAL HEPATITIS (2021)

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Review Virology

Novel Biomarkers of Hepatitis B Virus and Their Use in Chronic Hepatitis B Patient Management

Alicia Vachon et al.

Summary: Despite the lack of predictive markers for guiding clinical management and allowing treatment cessation with reduced risk of viral reactivation, the development of novel HBV biomarkers is helping to improve the management of individuals with chronic hepatitis B. The utility of these biomarkers in both treatment-naive and treated CHB patients has been widely discussed.

VIRUSES-BASEL (2021)

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Article Virology

HDV Seroprevalence in HBsAg-Positive Patients in China Occurs in Hotspots and Is Not Associated with HCV Mono-Infection

Imme Roggenbach et al.

Summary: HDV infection causes severe liver disease, but the seroprevalence of HDV varies among HBV and HCV patients in China and Germany, with studies showing that HCV cannot promote HDV transmission in humans.

VIRUSES-BASEL (2021)

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Article Medicine, General & Internal

A Non-invasive Model for Predicting Liver Inflammation in Chronic Hepatitis B Patients With Normal Serum Alanine Aminotransferase Levels

Xiaoke Li et al.

Summary: The study established a non-invasive model to predict significant liver inflammation in CHB patients with normal ALT levels. The model, composed of four variables, demonstrated good discrimination and calibration in both training and validation sets.

FRONTIERS IN MEDICINE (2021)

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Article Multidisciplinary Sciences

A novel model of care for simplified testing of HBV in African communities during the COVID-19 pandemic in Spain

Camila A. Picchio et al.

Summary: The HBV-COMSAVA study aimed to screen and vaccinate African migrants in Barcelona for HBV using point-of-care testing and simplified diagnostic tools during the COVID-19 pandemic. Results showed that despite the challenges of the pandemic, it was possible to diagnose, link to care, and vaccinate African migrants in a community-based setting.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Hepatitis B Core-related Antigen: An Alternative to Hepatitis B Virus DNA to Assess Treatment Eligibility in Africa

Yusuke Shimakawa et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Infectious Diseases

Performance of the Xpert HBV Viral Load assay versus the Aptima Quant assay for quantifying hepatitis B virus DNA

Florence Abravanel et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2020)

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Article Gastroenterology & Hepatology

Hepatitis B virus pregenomic RNA status can reveal the long-term prognoses of chronic hepatitis B patients treated with nucleos(t)ide analogues

Hao Luo et al.

JOURNAL OF VIRAL HEPATITIS (2020)

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Article Immunology

Hepatitis Be Antigen (HBeAg) Rapid Test and Alanine Aminotransferase Level-Based Algorithm to Identify Pregnant Women at Risk of HBV Mother-to-Child Transmission: The ANRS 12345 TA PROHM Study

Olivier Segeral et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Review Gastroenterology & Hepatology

The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis

Alexander J. Stockdale et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Virology

Reverse transcriptase droplet digital PCR vs reverse transcriptase quantitative real-time PCR for serum HBV RNA quantification

Umaporn Limothai et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Oncology

Combination of inflammatory score/liver function and AFP improves the diagnostic accuracy of HBV-related hepatocellular carcinoma

Yezhou Ding et al.

CANCER MEDICINE (2020)

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Article Virology

Evaluation of the Xpert HBV Viral Load for hepatitis B virus molecular testing

Lila Poiteau et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Article Infectious Diseases

Molecular epidemiology and clinical characteristics of hepatitis delta virus (HDV) infected patients with elevated transaminases in Shanghai, China

Shanshan Wu et al.

BMC INFECTIOUS DISEASES (2020)

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Review Cell Biology

Point-of-Care Tests for Hepatitis B: An Overview

Yinzong Xiao et al.

CELLS (2020)

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Article Surgery

Evaluation of the Alpha-Fetoprotein Model for Predicting Recurrence and Survival in Patients With Hepatitis B Virus (HBV)-Related Cirrhosis Who Received Liver Transplantation for Hepatocellular Carcinoma

Ao Ren et al.

FRONTIERS IN SURGERY (2020)

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Article Biochemical Research Methods

Head-to-head comparison of Enzyme Linked Immunosorbent Assay (ELISA) and Enhanced Chemiluminescence Immunoassay (ECLIA) for the detection of Transfusion Transmitted Disease (TTD) Markers; HIV, HCV and HBV in blood donors, in India

Aseem Kumar Tiwari et al.

JOURNAL OF VIROLOGICAL METHODS (2020)

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Article Infectious Diseases

Comparison of anti-hepatitis D virus (HDV) ETI-AB-DELTAK-2 assay and the novel LIAISON® XL MUREX anti-HDV assay in the diagnosis of HDV infection

Caterina Rocco et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2019)

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Review Pharmacology & Pharmacy

Non-invasive biomarkers for chronic hepatitis B virus infection management

Caroline Charre et al.

ANTIVIRAL RESEARCH (2019)

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Article Multidisciplinary Sciences

An Automated, Quantitative, and Multiplexed Assay Suitable for Point-of-Care Hepatitis B Virus Diagnostics

Adi Wijaya Gani et al.

SCIENTIFIC REPORTS (2019)

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Review Gastroenterology & Hepatology

An update on the management of chronic hepatitis D

Pir Ahmad Shah et al.

GASTROENTEROLOGY REPORT (2019)

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Article Gastroenterology & Hepatology

New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection

Carla S. Coffin et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection

Shi Liu et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients

Barbara Testoni et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Medicine, Research & Experimental

Diagnostic value of alpha-fetoprotein, Lens culinaris agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma

Ting Song et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2019)

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Article Gastroenterology & Hepatology

Clinical and virological heterogeneity of hepatitis delta in different regions world-wide: The Hepatitis Delta International Network (HDIN)

Anika Wranke et al.

LIVER INTERNATIONAL (2018)

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Article Public, Environmental & Occupational Health

Poor Sensitivity of Commercial Rapid Diagnostic Tests for Hepatitis B e Antigen in Senegal, West Africa

Abdoulaye Seck et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2018)

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Article Infectious Diseases

Characterization of hepatitis B and delta coinfection in Israel

Rachel Shirazi et al.

BMC INFECTIOUS DISEASES (2018)

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Article Gastroenterology & Hepatology

Host and viral factors associated with serum hepatitis B virus RNA levels among patients in need for treatment

Margo J. H. van Campenhout et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Hepatitis B Virus Serum DNA and RNA Levels in Nucleos(t)ide Analog-Treated or Untreated Patients During Chronic and Acute Infection

Emily K. Butler et al.

HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Clinical evaluation of a novel and highly sensitive immunoassay for anti-hepatitis B core antigen using a fully automated immunochemical analyzer

Kyo Izumida et al.

HEPATOLOGY RESEARCH (2018)

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Article Gastroenterology & Hepatology

Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa

Yusuke Shimakawa et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Gastroenterology & Hepatology

Quantification of serum markers of hepatitis B (HBV) and Delta virus (HDV) infections in patients with chronic HDV infection

G. Ricco et al.

JOURNAL OF VIRAL HEPATITIS (2018)

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Article Gastroenterology & Hepatology

Natural history of serum HBV-RNA in chronic HBV infection

J. Wang et al.

JOURNAL OF VIRAL HEPATITIS (2018)

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Article Multidisciplinary Sciences

Development and performance of prototype serologic and molecular tests for hepatitis delta infection

Kelly E. Coller et al.

SCIENTIFIC REPORTS (2018)

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Review Infectious Diseases

Global epidemiology of viral hepatitis and national needs for complete control

Simone Lanini et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2018)

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Review Gastroenterology & Hepatology

Genetic diversity of hepatitis viruses in West-African countries from 1996 to 2018

Maleki Assih et al.

WORLD JOURNAL OF HEPATOLOGY (2018)

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Review Gastroenterology & Hepatology

Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection

L. -Y. Mak et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2018)

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Article Microbiology

Performance Characteristics of a New Consensus Commercial Kit for Hepatitis D Virus RNA Viral Load Quantification

Frederic Le Gal et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2017)

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Article Gastroenterology & Hepatology

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Novel monitoring of hepatitis B reactivation based on ultra-high sensitive hepatitis B surface antigen assay

Noboru Shinkai et al.

LIVER INTERNATIONAL (2017)

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Article Gastroenterology & Hepatology

Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA

Danny Ka-Ho Wong et al.

LIVER INTERNATIONAL (2017)

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Review Virology

Hepatitis delta: virological and clinical aspects

Luan Felipo Botelho-Souza et al.

VIROLOGY JOURNAL (2017)

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Review Infectious Diseases

Diagnostic accuracy of tests to detect hepatitis B surface antigen: a systematic review of the literature and meta-analysis

Ali Amini et al.

BMC INFECTIOUS DISEASES (2017)

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Article Gastroenterology & Hepatology

The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa

Maud Lemoine et al.

GUT (2016)

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Article Biochemistry & Molecular Biology

Correlation between hepatitis B virus DNA levels and diagnostic tests for HBsAg, HBeAg, and PreS1-Ag in chronic hepatitis B

X. Liu et al.

GENETICS AND MOLECULAR RESEARCH (2016)

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Article Gastroenterology & Hepatology

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound

Jie Wang et al.

JOURNAL OF HEPATOLOGY (2016)

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Article Gastroenterology & Hepatology

Implementation of an in-house quantitative real-time polymerase chain reaction method for Hepatitis B virus quantification in West African countries

S. Ghosh et al.

JOURNAL OF VIRAL HEPATITIS (2016)

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Article Gastroenterology & Hepatology

Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype

Antonio Madejon et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Article Public, Environmental & Occupational Health

Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study

Maud Lemoine et al.

LANCET GLOBAL HEALTH (2016)

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Article Medicine, General & Internal

Comparing Assay Performance of ELISA and Chemiluminescence Immunoassay in Detecting Antibodies to Hepatitis B Surface Antigen

Mridula Madiyal et al.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2016)

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Article Infectious Diseases

Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection

L. -W. Song et al.

CLINICAL MICROBIOLOGY AND INFECTION (2015)

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Letter Microbiology

Comparative Performance of Three Rapid HBsAg Assays for Detection of HBs Diagnostic Escape Mutants in Clinical Samples

Annabelle Servant-Delmas et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

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Article Microbiology

Validation of Rapid Point-of-Care (POC) Tests for Detection of Hepatitis B Surface Antigen in Field and Laboratory Settings in the Gambia, Western Africa

Harr Freeya Njai et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2015)

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Article Gastroenterology & Hepatology

Serum Hepatitis B Virus RNA Levels as an Early Predictor of Hepatitis B Envelope Antigen Seroconversion During Treatment With Polymerase Inhibitors

Florian van Boemmel et al.

HEPATOLOGY (2015)

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Article Multidisciplinary Sciences

Total Hepatitis B Core Antigen Antibody, a Quantitative Non-Invasive Marker of Hepatitis B Virus Induced Liver Disease

Quan Yuan et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

A Mechanistic Assessment of the Discordance between Normal Serum Alanine Aminotransferase Levels and Altered Liver Histology in Chronic Hepatitis B

Xianqiong Gong et al.

PLOS ONE (2015)

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Article Virology

A one step real time PCR method for the quantification of hepatitis delta virus RNA using an external armored RNA standard and intrinsic internal control

Ersin Karatayli et al.

JOURNAL OF CLINICAL VIROLOGY (2014)

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Article Virology

Performance of a new rapid test for the detection of hepatitis B surface antigen in various patient populations

Stephane Chevaliez et al.

JOURNAL OF CLINICAL VIROLOGY (2014)

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Article Multidisciplinary Sciences

Anti-HDV IgM as a Marker of Disease Activity in Hepatitis Delta

Anika Wranke et al.

PLOS ONE (2014)

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Article Gastroenterology & Hepatology

Natural history of chronic hepatitis B: Phases in a complex relationship

Catherine M. N. Croagh et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Gastroenterology & Hepatology

Development and assessment of a novel real-time PCR assay for quantitation of hepatitis D virus RNA to study viral kinetics in chronic hepatitis D

A. Katsoulidou et al.

JOURNAL OF VIRAL HEPATITIS (2013)

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Article Biochemical Research Methods

One-step real-time PCR assay for detection and quantitation of hepatitis D virus RNA

Maja Kodani et al.

JOURNAL OF VIROLOGICAL METHODS (2013)

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Review Multidisciplinary Sciences

Association of Early Age at Establishment of Chronic Hepatitis B Infection with Persistent Viral Replication, Liver Cirrhosis and Hepatocellular Carcinoma: A Systematic Review

Yusuke Shimakawa et al.

PLOS ONE (2013)

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Article Gastroenterology & Hepatology

Preserved T-Cell Function in Children and Young Adults With Immune-Tolerant Chronic Hepatitis B

Patrick T. F. Kennedy et al.

GASTROENTEROLOGY (2012)

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Article Microbiology

Standardized One-Step Real-Time Reverse Transcription-PCR Assay for Universal Detection and Quantification of Hepatitis Delta Virus from Clinical Samples in the Presence of a Heterologous Internal-Control RNA

Caroline Scholtes et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2012)

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Review Gastroenterology & Hepatology

Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: A systematic review

George V. Papatheodoridis et al.

JOURNAL OF HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation

Ingmar Mederacke et al.

JOURNAL OF HEPATOLOGY (2012)

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Article Biochemical Research Methods

Quantitation of hepatitis delta virus using a single-step internally controlled real-time RT-ciPCR and a full-length genomic RNA calibration standard

R. B. Ferns et al.

JOURNAL OF VIROLOGICAL METHODS (2012)

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Article Biochemical Research Methods

Development and validation of an efficient in-house real-time reverse transcription polymerase chain reaction assay for the quantitative detection of serum hepatitis delta virus RNA in a diverse South London population

Dazhuang Shang et al.

JOURNAL OF VIROLOGICAL METHODS (2012)

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Editorial Material Gastroenterology & Hepatology

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Article Infectious Diseases

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Article Virology

Correlation Between Serum Hepatitis B Virus Core-Related Antigen and Intrahepatic Covalently Closed Circular DNA in Chronic Hepatitis B Patients

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Article Gastroenterology & Hepatology

Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response

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A genotype-independent real-time PCR assay for quantification of hepatitis B virus DNA

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Quantitative analysis of HBsAg, IgM anti-HBc and anti-HBc avidity in acute and chronic hepatitis B

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JOURNAL OF CLINICAL VIROLOGY (2006)

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Article Virology

Fully automated quantitation of hepatitis B virus (HBV) DNA in human plasma by the COBAS® AmpliPrep/COBAS® TaqMan® system

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Article Gastroenterology & Hepatology

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Hepatitis B e antigen and the risk of hepatocellular carcinoma

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Viral Diagnosis of Hepatitis B and Delta: What We Know and What Is Still Required? Specific Focus on Low- and Middle-Income Countries

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