期刊
MICROORGANISMS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10102066
关键词
allergic rhinitis; asthma; chronic rhinosinusitis; immune disorder; bacterial microbiome
类别
资金
- National Natural Science Foundation of China [81370113, 81970719]
Complex changes in the microbiota of the respiratory and intestinal tracts in patients with allergic respiratory diseases are associated with immune disorders and could potentially be targeted for therapy.
Allergic respiratory disease is a worldwide and increasingly prevalent health problem. Many researchers have identified complex changes in the microbiota of the respiratory and intestinal tracts in patients with allergic respiratory diseases. These affect immune response and influence the progression of disease. However, the diversity of bacterial changes in such cases make it difficult to identify a specific microorganism to target for adjustment. Recent research evidence suggests that common bacterial variations present in allergic respiratory disease are associated with immune disorders. This finding could lead to the discovery of potential therapeutic targets in cases of allergic respiratory disease. In this review, we summarize current knowledge of bacteria changes in cases of allergic respiratory disease, to identify changes commonly associated with immune disorders, and thus provide a theoretical basis for targeting therapies of allergic respiratory disease through effective modulation of key bacteria.
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