期刊
MICROORGANISMS
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10091843
关键词
magnetron sputtering; transition metals; biofilm; antibacterial surfaces; pseudomonas aeruginosa
类别
资金
- State of North Rhine-Westphalia using funds from the European Regional Development Fund (EFRE) [EFRE-1803FI12]
- Center for Interdisciplinary Material Research and Technology Development (CiMT)
- University of Bielefeld
This study investigated the application of magnetron sputtering of various transition metals in antimicrobial coatings, finding that gold had the strongest antibacterial effect. These antimicrobial coatings show great potential for application on household appliances and surgical instruments.
In the light of the SARS-CoV-2 pandemic and growing numbers of bacteria with resistance to antibiotics, the development of antimicrobial coatings is rising worldwide. Inorganic coatings are attractive because of low environmental leakage and wear resistance. Examples for coatings are hot metal dipping or physical vapor deposition of nanometer coatings. Here, magnetron sputtering of various transition metals, such as gold, ruthenium and tantalum, was investigated. Metal films were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM) and energy dispersive X-ray spectroscopy (EDX). We investigated the growth of Pseudomonas aeruginosa isolated from household appliances on different sputter-coated metal surfaces. The fine-grained nanometric structure of these metal coatings was between 14 nm (tantalum) and 26 nm (gold) and the roughness was in a range of 164 pm (ruthenium) to 246 pm (gold). Antibacterial efficacy of metal surfaces followed the order: gold > tantalum > ruthenium. Interestingly, gold had the strongest inhibitory effect on bacterial growth, as analyzed by LIVE/DEAD and CFU assay. High-magnification SEM images showed dead bacteria characterized by shrinkage induced by metal coatings. We conclude that sputtering might be a new application for the development of antimicrobial surfaces on household appliances and or surgical instruments.
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