期刊
MICROORGANISMS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10101975
关键词
Pseudomonas species; antimicrobial resistance; biofilm formation; clove oil; plasmid; PCR; AmpC beta-Lactamases
类别
资金
- Deanship of Scientific Research, Qassim University
Pseudomonas species isolates from chickens showed resistance to most antibiotics, particularly those from the beta-lactamase family. PCR confirmed the correlation between multidrug-resistant isolates and biofilm-related genes, and revealed the potent antibiofilm effect of clove oil against Pseudomonas.
Bacteria of the genus Pseudomonas are pathogens in both humans and animals. The most prevalent nosocomial pathogen is P. aeruginosa, particularly strains with elevated antibiotic resistance. In this study, a total of eighteen previously identified Pseudomonas species strains, were isolated from chicken. These strains were screened for biofilm formation and antibiotic resistance. In addition, we evaluated clove oil's effectiveness against Pseudomonas isolates as an antibiofilm agent. The results showed that Pseudomonas species isolates were resistant to most antibiotics tested, particularly those from the beta-lactamase family. A significant correlation (p < 0.05) between the development of multidrug-resistant isolates and biofilms is too informal. After amplifying the AmpC-plasmid-mediated genes (bla(CMY), bla(MIR), DHA, and FOX) and biofilm-related genes (psld, rhlA, and pelA) in most of our isolates, PCR confirmed this relationship. Clove oil has a potent antibiofilm effect against Pseudomonas isolates, and may provide a treatment for bacteria that form biofilms and are resistant to antimicrobials.
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