☆ 4.6 Article

Persistent Nonviral Plasmid Vector in Nasal Tissues Causes False-Positive SARS-CoV-2 Diagnostic Nucleic Acid Tests

MICROBIOLOGY SPECTRUM (2022)

Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results

Lindsey R. Robinson-McCarthy et al.

Summary: The COVID-19 pandemic has led to widespread use of highly sensitive molecular diagnostics, but also raised concerns about the interference of nucleic acids generated in research environments with virus testing. Researchers may test positive for SARS-CoV-2 even without direct exposure to these nucleic acids, highlighting the need for increased stewardship over diagnostically relevant molecules.

MICROBIOLOGY SPECTRUM (2021)

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Article Microbiology