4.6 Article

Preferential Selection of Low-Frequency, Lipopolysaccharide-Modified, Colistin-Resistant Mutants with a Combination of Antimicrobials in Acinetobacter baumannii

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Infectious Diseases

In search for a synergistic combination against pandrug-resistant A. baumannii; methodological considerations

Stamatis Karakonstantis et al.

Summary: This manuscript systematically reviews the methodology and unique considerations for assessing antimicrobial combinations against pandrug-resistant A. baumannii (PDRAB). The review analyzes various synergy testing methods used in previous studies and identifies challenges related to testing inactive antimicrobial combinations. Consensus on standardized methodology and clinically relevant definitions for synergy is needed.

INFECTION (2022)

Article Immunology

Molecular Epidemiology and Clone Transmission of Carbapenem-Resistant Acinetobacter baumannii in ICU Rooms

Xiufeng Zhang et al.

Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a significant concern in hospitals worldwide. A study in a Chinese hospital ICU over six years found that all 105 CRAB isolates belonged to a global clone CC2, with some popular clones and significant differences in community structure over time. The findings suggest a potential clone outbreak in the hospital ICU, highlighting the substantial burden of multidrug-resistant CRAB in this environment.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Microbiology

Acinetobacter baumannii Can Survive with an Outer Membrane Lacking Lipooligosaccharide Due to Structural Support from Elongasome Peptidoglycan Synthesis

Brent W. Simpson et al.

Summary: Gram-negative bacteria resist external stresses due to cell envelope rigidity, provided by two membranes and a peptidoglycan layer. The importance of LPS/LOS, high PBP1A levels, axial peptidoglycan synthesis, and elongasome function in LOS-deficient cells was identified. The data suggest that the outer membrane and peptidoglycan both contribute to cell rigidity.
Article Infectious Diseases

Effect of Subinhibitory Concentrations of Antibiotics and Disinfectants on ISAba-Mediated Inactivation of Lipooligosaccharide Biosynthesis Genes in Acinetobacter baumannii

Hector Olmeda-Lopez et al.

Summary: This study explores previously uncharacterized aspects regarding the acquisition of colistin resistance through insertional activation in LOS biosynthesis genes in A. baumannii. The findings suggest that subinhibitory concentrations of tetracycline significantly increase ISAba11 insertion, and rifampicin completely inhibits the emergence of colistin resistance due to ISAba11 inactivation of lpxC. Sequencing of ISAba11 insertion sites within the lpxC gene demonstrates a hotspot for insertion between nucleotides 382 and 618, with a semi-conserved AT-rich consensus sequence upstream of the insertion site.

ANTIBIOTICS-BASEL (2021)

Review Infectious Diseases

Systematic Review of Antimicrobial Combination Options for Pandrug-Resistant Acinetobacter baumannii

Stamatis Karakonstantis et al.

Summary: Combination antimicrobial therapy is currently the only potential treatment option for pandrug-resistant A. baumannii. Some combinations exhibit synergy at clinically relevant concentrations, with triple combinations showing greater activity than double combinations, but no combination consistently demonstrates synergy against all strains tested.

ANTIBIOTICS-BASEL (2021)

Review Medicine, General & Internal

Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria

Firdoos Ahmad Gogry et al.

Summary: The global interest in colistin has risen due to the prevalence of multidrug-resistant Gram-negative Enterobacteriaceae, leading to the emergence of colistin-resistant bacteria. However, some Gram-negative species are intrinsically resistant to colistin, and most identified colistin resistance involves modification of lipid A to decrease or remove interaction with colistin. Changes in membrane structure, specifically in the outer membrane lipopolysaccharide (LPS), play a key role in colistin resistance mechanisms. New methods and approaches are being developed to detect and combat colistin resistance, with a focus on developing less toxic and more effective drugs to treat bacterial infections.

FRONTIERS IN MEDICINE (2021)

Article Infectious Diseases

In Vitro Synergy of Colistin in Combination with Meropenem or Tigecycline against Carbapenem-Resistant Acinetobacter baumannii

Jacinda C. Abdul-Mutakabbir et al.

Summary: The study explored the potential utility of antibiotic combinations for carbapenem-resistant Acinetobacter baumannii isolates, identifying synergistic and bactericidal effects in certain combination therapies. Results suggest that certain antibiotic combinations can restore efficacy against resistant strains, offering new treatment options for difficult-to-treat infections caused by Acinetobacter baumannii.

ANTIBIOTICS-BASEL (2021)

Article Biology

Characterization of multidrug-resistant Acinetobacter baumannii strain ATCC BAA1605 using whole-genome sequencing

Kah Ern Ten et al.

Summary: This study analyzed the genomic features of multidrug-resistant Acinetobacter baumannii strain ATCC BAA1605, revealing the presence of a circular chromosome and plasmid with numerous antimicrobial resistance genes and genomic islands. The identification of a subtype I-F CRISPR-Cas system suggests mechanisms for potential horizontal gene transfer in this pathogen. This valuable genome data can serve as a reference for future studies on A. baumannii.

BMC RESEARCH NOTES (2021)

Review Infectious Diseases

Pandrug-resistant Gram-negative bacteria: a systematic review of current epidemiology, prognosis and treatment options

Stamatis Karakonstantis et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Article Infectious Diseases

Diversity of amino acid substitutions in PmrCAB associated with colistin resistance in clinical isolates of Acinetobacter baumannii

Stefanie Gerson et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Public, Environmental & Occupational Health

Excess mortality due to pandrug-resistant Acinetobacter baumannii infections in hospitalized patients

S. Karakonstantis et al.

JOURNAL OF HOSPITAL INFECTION (2020)

Review Immunology

Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)

Mohamed Abd El-Gawad El-Sayed Ahmed et al.

EMERGING MICROBES & INFECTIONS (2020)

Review Microbiology

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

Burcu Isler et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Review Genetics & Heredity

Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

Mohammad Hamidian et al.

MICROBIAL GENOMICS (2019)

Review Biochemistry & Molecular Biology

Expanding the paradigm for the outer membrane: Acinetobacter baumannii in the absence of endotoxin

Matthew Joseph Powers et al.

MOLECULAR MICROBIOLOGY (2018)

Review Microbiology

Uncovering the mechanisms of Acinetobacter baumannii virulence

Christian M. Harding et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Infectious Diseases

Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat

William Gustavo Lima et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2018)

Article Infectious Diseases

Highly synergistic activity of melittin with imipenem and colistin in biofilm inhibition against multidrug-resistant strong biofilm producer strains of Acinetobacter baumannii

Ali Mohammadi Bardbari et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2018)

Article Biochemistry & Molecular Biology

Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors

Norihiko Takemoto et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Infectious Diseases

Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii

Mustapha M. Mustapha et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2018)

Article Infectious Diseases

Resistance to polymyxins in Gram-negative organisms

Katy Jeannot et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2017)

Article Multidisciplinary Sciences

Transition of colistin dependence into colistin resistance in Acinetobacter baumannii

Ji-Young Lee et al.

SCIENTIFIC REPORTS (2017)

Article Biochemical Research Methods

Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads

Ryan R. Wick et al.

PLOS COMPUTATIONAL BIOLOGY (2017)

Review Immunology

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

Chang-Ro Lee et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

Article Infectious Diseases

Epidemiology and Genetic Diversity of Colistin Nonsusceptible Nosocomial Acinetobacter baumannii Strains from Russia for 2013-2014

Eugene A. Sheck et al.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2017)

Review Medicine, General & Internal

Old drug, new findings: colistin resistance and dependence of Acinetobacter baumannii

Kwan Soo Ko et al.

PRECISION AND FUTURE MEDICINE (2017)

Article Immunology

Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance

Zubair A. Qureshi et al.

CLINICAL INFECTIOUS DISEASES (2015)

Review Medicine, General & Internal

Colistin, mechanisms and prevalence of resistance

Abed Zahedi Bialvaei et al.

CURRENT MEDICAL RESEARCH AND OPINION (2015)

Article Biochemical Research Methods

Prokka: rapid prokaryotic genome annotation

Torsten Seemann

BIOINFORMATICS (2014)

Review Microbiology

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

Abiola O. Olaitan et al.

FRONTIERS IN MICROBIOLOGY (2014)

Review Immunology

Acinetobacter baumannii: evolution of a global pathogen

Luisa C. S. Antunes et al.

PATHOGENS AND DISEASE (2014)

Review Infectious Diseases

Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies

Yun Cai et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2012)

Article Microbiology

Insertion Sequence ISAba11 Is Involved in Colistin Resistance and Loss of Lipopolysaccharide in Acinetobacter baumannii

Jennifer H. Moffatt et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Article Microbiology

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

Jennifer H. Moffatt et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Article Infectious Diseases

Global spread of carbapenem-resistant Acinetobacter baumannii

Paul G. Higgins et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)

Article Infectious Diseases

Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii

Sidharth Chopra et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)

Article Infectious Diseases

Independent emergence of colistin-resistant Acinetobacter spp. isolates from Korea

Young Kyoung Park et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2009)

Review Microbiology

Acinetobacter baumannii:: Emergence of a successful pathogen

Anton Y. Peleg et al.

CLINICAL MICROBIOLOGY REVIEWS (2008)

Review Microbiology

Global challenge of multidrug-resistant Acinetobacter baumannii

Federico Perez et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)

Article Immunology

The epidemiology and control of Acinetobacter baumannii in health care facilities

PE Fournier et al.

CLINICAL INFECTIOUS DISEASES (2006)