期刊
ANTIOXIDANTS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/antiox11091811
关键词
oxidative stress; intracerebral hemorrhage; natural products; antioxidants; stroke
资金
- National Natural Science Foundation of China [82174047, 81622051]
- Zhejiang Provincial Natural Science Foundation of China [LY22H280004]
This review explores the potential of natural products therapy to target oxidative stress (OS) in intracerebral hemorrhage (ICH). Numerous studies have demonstrated the potent antioxidant properties of natural products, including polyphenols, phenolic compounds, terpenoids, alkaloids, etc. These natural products offer the possibility of treatment of OS after ICH, but further research is needed for their wider application in the clinic.
Intracerebral hemorrhage (ICH), the second most common subtype of stroke, remains a significant cause of morbidity and mortality worldwide. The pathological mechanism of ICH is very complex, and it has been demonstrated that oxidative stress (OS) plays an important role in the pathogenesis of ICH. Previous studies have shown that OS is a therapeutic target after ICH, and antioxidants have also achieved some benefits in the treatment of ICH. This review aimed to explore the promise of natural products therapy to target OS in ICH. We searched PubMed using the keywords oxidative stress in intracerebral hemorrhage and natural products in intracerebral hemorrhage. Numerous animal and cell studies on ICH have demonstrated the potent antioxidant properties of natural products, including polyphenols and phenolic compounds, terpenoids, alkaloids, etc. In summary, natural products such as antioxidants offer the possibility of treatment of OS after ICH. However, researchers still have a long way to go to apply these natural products for the treatment of ICH more widely in the clinic.
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