期刊
ANTIOXIDANTS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/antiox11091660
关键词
blue light; mouse model; photoinactivation; porphyrins; Pseudomonas aeruginosa; rose bengal; Staphylococcus aureus; synergy
资金
- National Centre of Science (Poland) [2015/19/B/NZ7/02487]
This study confirmed the effectiveness of antimicrobial blue light in combination with antibiotics against multidrug-resistant Pseudomonas aeruginosa and Staphylococcus aureus, with in vivo experiments demonstrating synergy between the two treatments.
Increased development of resistance to antibiotics among microorganisms promotes the evaluation of alternative approaches. Within this study, we examined the efficacy of antimicrobial blue light (aBL) with routinely used antibiotics against multidrug-resistant isolates of Pseudomonas aeruginosa and Staphylococcus aureus as combined alternative treatment. In vitro results of this study confirm that both S. aureus and P. aeruginosa can be sensitized to antibiotics, such as chloramphenicol, linezolid, fusidic acid or colistin, fosfomycin and ciprofloxacin, respectively. The assessment of increased ROS production upon aBL exposure and the changes in cell envelopes permeability were also goals that were completed within the current study. Moreover, the in vivo experiment revealed that, indeed, the synergy between aBL and antibiotic (chloramphenicol) occurs, and the results in the reduced bioluminescence signal of the S. aureus Xen31 strain used to infect the animal wounds. To conclude, we are the first to present the possible mechanism explaining the observed synergies among photoinactivation with blue light and antibiotics in the term of Gram-positive and Gram-negative representatives.
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