4.7 Article

Gold Nanoparticles Inhibit Steroid-Insensitive Asthma in Mice Preserving Histone Deacetylase 2 and NRF2 Pathways

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Critical Care Medicine

Global Initiative for Asthma Strategy 2021 Executive Summary and Rationale for Key Changes

Helen K. Reddel et al.

Summary: The article summarizes key recommendations from GINA 2021 and the recent changes, highlighting the importance of not relying solely on short-acting beta(2)-agonists for asthma treatment and provides targeted treatment suggestions based on severity and age.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Article Cell Biology

Assessment of Allergen-Responsive Regulatory T Cells in Experimental Asthma Induced in Different Mouse Strains

C. T. Azevedo et al.

Summary: Regulatory T cells (Tregs) play important roles in regulating responses to innocuous antigens and controlling Th2 response, and the frequencies of Treg cell subtypes are different among isogenic mouse strains with susceptibility to experimental asthma. A/J mice have higher frequency of CD4(+)IL-10(+) T cells, while C57BL/6 mice have higher frequency of CD4(+)CD25(+)Foxp3(+) Treg cells in response to allergen challenge.

MEDIATORS OF INFLAMMATION (2021)

Article Biotechnology & Applied Microbiology

Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis

Davide Di Bella et al.

Summary: The study found that 20 nm cit-AuNP has important anti-inflammatory properties in the brain of mice with sepsis and could be a potential candidate as an adjuvant drug along with antibiotics in the treatment of sepsis to prevent SAE.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Cell Biology

The Role of Glucocorticoids in Inflammatory Diseases

Sybille D. Reichardt et al.

Summary: Glucocorticoids have been a powerful and affordable treatment option for inflammatory diseases for over 70 years, but their benefits come with side effects. Efforts are being made to improve their therapeutic index through novel approaches such as chemical modifications and nanoformulations. Despite being one of the oldest class of drugs in medical use, GCs remain a topic of highly active scientific research.
Article Biochemistry & Molecular Biology

Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages

Stephanie B. Wall et al.

Summary: The gold compound AFN suppresses IL-1β synthesis by activating NRF2 directly, independent of NFκB and glutathione-mediated antioxidant mechanisms. NRF2 binding to the promoter region of IL1β inhibits transcription of the IL1β gene.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD

Brandon W. Lewis et al.

Summary: The paragraph discusses how oxidative stress contributes to corticosteroid insensitivity in patients with severe asthma and COPD, emphasizing the importance of optimizing endogenous antioxidant responses to enhance corticosteroid sensitivity. Future studies should explore how antioxidant-based therapies can complement corticosteroids to reduce the need for prolonged high dose regimens in these patients.

ANTIOXIDANTS (2021)

Review Pharmacology & Pharmacy

G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

Stacy Gelhaus Wendell et al.

PHARMACOLOGICAL REVIEWS (2020)

Review Biochemistry & Molecular Biology

Therapeutic Nanoparticles and Their Targeted Delivery Applications

Abuzer Alp Yetisgin et al.

MOLECULES (2020)

Article Physiology

HDAC2 attenuates airway inflammation by suppressing IL-17A production in HDM-challenged mice

Tianwen Lai et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Article Allergy

The Role of Neutrophils in Asthma

Reynold A. Panettieri

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2018)

Review Immunology

Targeting cytokines to treat asthma and chronic obstructive pulmonary disease

Peter J. Barnes

NATURE REVIEWS IMMUNOLOGY (2018)

Review Immunology

Neutrophilic Inflammation in Asthma and Association with Disease Severity

Anuradha Ray et al.

TRENDS IN IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Glucocorticoid resistance in chronic diseases

Juan M. Rodriguez et al.

STEROIDS (2016)

Article Nanoscience & Nanotechnology

Local Administration of Gold Nanoparticles Prevents Pivotal Pathological Changes in Murine Models of Atopic Asthma

Emiliano Barreto et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

Article Chemistry, Multidisciplinary

Nano-Gold as Artificial Enzymes: Hidden Talents

Youhui Lin et al.

ADVANCED MATERIALS (2014)

Review Nanoscience & Nanotechnology

Gold nanoparticle mediated cancer immunotherapy

Joao Paulo Mattos Almeida et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

Article Chemistry, Multidisciplinary

Manipulation of in Vitro Angiogenesis Using Peptide-Coated Gold Nanoparticles

Dorota Bartczak et al.

ACS NANO (2013)

Article Allergy

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

Peter J. Barnes

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Allergy

Severe adult-onset asthma: A distinct phenotype

Marijke Amelink et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities

Anne M. Fitzpatrick et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Pharmacology & Pharmacy

Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition

C. Rossios et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Allergy

Severe asthma: from characteristics to phenotypes to endotypes

S. Wenzel

CLINICAL AND EXPERIMENTAL ALLERGY (2012)

Article Chemistry, Medicinal

Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives

Zdenek Travnicek et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

A. Boutten et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Review Biochemistry & Molecular Biology

Redox Control of Asthma: Molecular Mechanisms and Therapeutic Opportunities

Suzy A. A. Comhair et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Editorial Material Chemistry, Multidisciplinary

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

Alaaldin M. Alkilany et al.

JOURNAL OF NANOPARTICLE RESEARCH (2010)

Review Immunology

Functions of T cells in asthma: more than just TH2 cells

Clare M. Lloyd et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Nanoscience & Nanotechnology

Assessment of the In Vivo Toxicity of Gold Nanoparticles

Yu-Shiun Chen et al.

NANOSCALE RESEARCH LETTERS (2009)

Article Toxicology

Clinical pharmacology of gold

W. F. Kean et al.

INFLAMMOPHARMACOLOGY (2008)

Article Rheumatology

Amelioration of collagen-induced arthritis in rats by nanogold

Chiau-Yuang Tsai et al.

ARTHRITIS AND RHEUMATISM (2007)

Review Pharmacology & Pharmacy

Nanomedicine for respiratory diseases

U Pison et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2006)

Article Immunology

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

T Rangasamy et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

Article Allergy

Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation

C Miranda et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

Review Allergy

Do mouse models of allergic asthma mimic clinical disease?

MM Epstein

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2004)