4.7 Review

Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells

Ceyhan Hacioglu et al.

Summary: This study investigated the effects of capsaicin on cell proliferation via ferroptosis in human glioblastoma cells. The results showed that capsaicin can inhibit cell proliferation by regulating various signaling pathways and inducing ferroptosis. Additionally, capsaicin caused changes in oxidative stress-related markers. The study suggests that capsaicin may be a potential anticancer agent for the treatment of glioblastoma.

METABOLIC BRAIN DISEASE (2023)

Article Oncology

Ferroptosis, as the most enriched programmed cell death process in glioma, induces immunosuppression and immunotherapy resistance

Tianqi Liu et al.

Summary: This study reveals the importance of ferroptosis in glioma and proposes a novel immunotherapeutic strategy that combines immune checkpoint blockade treatment with ferroptosis inhibition, showing a synergistic therapeutic effect.

NEURO-ONCOLOGY (2022)

Article Oncology

Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth

Sheng Zhan et al.

Summary: This study found that plumbagin inhibits glioma growth through targeting NQO1/GPX4-mediated ferroptosis, suggesting its potential as a novel inducer or candidate for anti-glioma therapy.

BRITISH JOURNAL OF CANCER (2022)

Review Biochemistry & Molecular Biology

Signaling pathways and defense mechanisms of ferroptosis

Jiao Liu et al.

Summary: Ferroptosis is a type of lytic cell death caused by unrestricted lipid peroxidation and cell membrane damage, driven by complex signaling pathways and regulatory mechanisms. The main substrates of lipid peroxidation in ferroptosis are phospholipids rich in polyunsaturated fatty acids, positively regulated by various enzymes. Selective activation of autophagic degradation pathways promotes ferroptosis, while the system xc(-)-glutathione-GPX4 axis plays a limiting role.

FEBS JOURNAL (2022)

Article Pharmacology & Pharmacy

Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway

Hanren Chen et al.

Summary: This study explored the inhibitory effect of iron oxide nanoparticles loaded with paclitaxel on glioblastoma and its potential mechanism, and found that the nanoparticles can inhibit the growth of glioblastoma by enhancing the autophagy-dependent ferroptosis pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

The mechanism of HMGB1 secretion and release

Ruochan Chen et al.

Summary: Inflammation-promoting nuclear protein HMGB1 can be targeted for controlling immune response in diseases linked to excessive inflammation. This article reviews the mechanisms of HMGB1 release and discusses its potential as a therapeutic target for inflammatory diseases and tissue damage.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

Article Pharmacology & Pharmacy

Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells

Qingxin Song et al.

Summary: This study found that artesunate can trigger ferroptosis in glioblastoma by regulating iron homeostasis and the p38 and ERK signaling pathways, indicating its potential role in glioblastoma treatment.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

Article Chemistry, Multidisciplinary

Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy

Boyan Li et al.

Summary: A novel composite therapeutic platform combining magnetic nanoparticles and engineered exosomes is proposed for GBM treatment, aiming to improve the penetration through the blood-brain barrier and enhance tumor targeting ability for effective ferroptosis therapy.

ADVANCED SCIENCE (2022)

Review Immunology

Activation and Regulation of NLRP3 by Sterile and Infectious Insults

Srijon K. Banerjee et al.

Summary: NLR is the largest family of PRRs that patrols the cytosolic environment. Dysregulation of NLRP3 inflammasome activity is associated with pathogenesis in several human diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cell Biology

Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells

Linhao You et al.

Summary: Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The study reveals that astrocytes regulate iron transport into the brain by controlling the expression of FPN1 in brain microvascular endothelial cells (BMVECs) through the secretion of hepcidin. The results provide potential therapeutic targets for iron dysregulation-related neurological diseases.

CELL DEATH & DISEASE (2022)

Article Materials Science, Biomaterials

Synergistic therapy for orthotopic gliomas via biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis

Mingting Zhu et al.

Summary: This study presents a novel therapeutic strategy for glioma treatment by combining sonodynamic therapy and ferroptosis. The developed nanoparticles selectively accumulate in tumors and increase reactive oxygen species levels while depleting glutathione, leading to the death of glioma cells. Additionally, noninvasive blood-brain barrier opening enhances the accumulation of nanoparticles and significantly reduces the size of gliomas.

BIOMATERIALS SCIENCE (2022)

Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

Article Medicine, General & Internal

Ferroptosis Involvement in Glioblastoma Treatment

Andrei-Otto Mitre et al.

Summary: Glioblastoma multiforme (GBM) is a deadly brain tumor with limited treatment options. Stimulation of ferroptosis, a form of cell death, has been found to inhibit GBM growth and improve patient survival.

MEDICINA-LITHUANIA (2022)

Article Cell Biology

Comprehensive landscape of STEAP family functions and prognostic prediction value in glioblastoma

Huaijun Chen et al.

Summary: This study explored the biological function and prognostic value of the STEAP family in GBM, identifying prognosis-related genes and developing a prognostic model for GBM prediction.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Clinical Neurology

Optimal treatment strategy for adult patients with newly diagnosed glioblastoma: a systematic review and network meta-analysis

Lei Jin et al.

Summary: This study compared the efficacy and safety of treatments based on the Stupp protocol for adult patients with newly diagnosed glioblastoma. Results showed that tumor-treating fields (TTF) combined with the Stupp protocol resulted in the most favorable overall survival for patients with and without MGMT promoter methylation. Different treatment options were optimal for patients with different MGMT promoter methylation statuses.

NEUROSURGICAL REVIEW (2021)

Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

Review Endocrinology & Metabolism

Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)

J. Aguirre et al.

Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a severe and debilitating condition, with oral risk factors and bone tissue osteocytes playing crucial roles. Further research is needed to understand the causes and mechanisms of osteocyte death in MRONJ.
Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT (SLC7A11)

Marina Yamamoto et al.

Summary: The study shows that stimulation of glioblastoma cells with epidermal growth factor (EGF) induces the upregulation of xCT, leading to cell death under glucose deprivation. Additionally, treatment with the mTOR inhibitor Torin 1 can suppress the EGF-induced upregulation of xCT and cell death.

CELLULAR SIGNALLING (2021)

Article Genetics & Heredity

Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

Ronan Chaligne et al.

Summary: This study reveals the key switches for state transitions in diffuse gliomas, recapitulating neurodevelopmental trajectories and highlighting dysregulated epigenetic mechanisms underlying gliomagenesis. The work also demonstrates heritability of malignant cell states and differences in cell state architectures in different types of glioma. Additionally, the study links tumor cell transcriptional states to epigenetics and shows the heritability and importance of these states for tumor plasticity.

NATURE GENETICS (2021)

Review Cell Biology

Ferroptosis: A New Promising Target for Lung Cancer Therapy

Rui Xiong et al.

Summary: Ferroptosis is a new type of regulatory cell death that is caused by the accumulation of iron and lipid peroxides. It has been shown to play a crucial role in tumor progression, especially in lung cancer. Inducing ferroptosis in cells can inhibit tumor cell growth and potentially reverse tumorigenesis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Cell Biology

A Ferroptosis-Related Prognostic Risk Score Model to Predict Clinical Significance and Immunogenic Characteristics in Glioblastoma Multiforme

Dongdong Xiao et al.

Summary: The FRGPRS model, consisting of five ferroptosis key hub genes, can predict survival and immune characteristics in GBM patients, guiding personalized therapeutic strategies.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Oncology

Diffuse Glioma Heterogeneity and Its Therapeutic Implications

James G. Nicholson et al.

Summary: Diffuse gliomas are characterized by high levels of genetic, epigenetic, and environmental heterogeneity, leading to extreme phenotypic heterogeneity at the cellular level and resistance to various therapies. The intratumoral heterogeneity and malignant cell state plasticity in gliomas pose significant challenges to the development of novel targeted therapies.

CANCER DISCOVERY (2021)

Article Oncology

Transcriptional Regulation of Amino Acid Transport in Glioblastoma Multiforme

Robyn A. Umans et al.

Summary: Glioblastoma multiforme (GBM) is a deadly brain tumor with limited treatment options. Recent research suggests that tumor protein 53 (TP53) is a molecular regulator of System xc- (SXC) in GBM, with its expression negatively correlated with xCT expression. This finding indicates that p53 may serve as a potential therapeutic target for GBM by regulating glutamate biology.

CANCERS (2021)

Article Chemistry, Multidisciplinary

Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action

Yuying Fang et al.

Summary: This study introduces a novel ferroptosis inhibitor, 9a, which blocks ferroptosis by disrupting the NCOA4-FTH1 protein-protein interaction and reducing the amount of bioavailable intracellular ferrous iron. The inhibitor shows promise in ameliorating ischemic-reperfusion injury in a rat model of ischemic stroke, suggesting potential as a drug target for neurological diseases.

ACS CENTRAL SCIENCE (2021)

Review Oncology

DHODH and cancer: promising prospects to be explored

Yue Zhou et al.

Summary: DHODH plays a crucial role in tumor progression, including de novo pyrimidine synthesis and the mitochondrial respiratory chain in cancer cells. Various DHODH inhibitors have been developed over the past decades to target DHODH and its additional effects.

CANCER & METABOLISM (2021)

Article Biology

Iron induces two distinct Ca2+ signalling cascades in astrocytes

Wenzheng Guan et al.

Summary: The study reveals two distinct molecular mechanisms by which iron ions trigger calcium signaling in astrocytes, shedding light on the regulation of intracellular calcium concentration in these cells. These findings contribute to our understanding of the functional role of astrocytes in normal neurodevelopment.

COMMUNICATIONS BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Overview of Ferroptosis and Synthetic Lethality Strategies

Yuko Kinowaki et al.

Summary: Ferroptosis is a type of iron-dependent, non-apoptotic cell death that sensitizes drug-resistant tumors and cancer stem cells. Synthetic lethal strategies, targeting mechanisms not directly addressed by conventional therapies, show potential for specific malignant cells with low toxicity and possible new drug combinations. The research focuses on exploring ferroptosis-related molecules and synthetic lethality for potential therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

Hochung Jang et al.

Summary: This review focuses on utilizing nanoparticles to target innate immune cells in tumor microenvironments. It emphasizes the immune-suppressive properties of some innate immune cells that limit clinical benefits, and the potential development of strategies by understanding the cross-talk between tumors and innate immune cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis

Hao-Yu Chuang et al.

Summary: The overexpression of NEDD4-1 in GBM and TMZ-resistant cells is associated with oncogenicity, tumorigenesis, and chemoresistance. Mechanistically, NEDD4-1 mediates the degradation of PTEN and upregulation of the AKT/NRF2/HO-1 signaling pathway, leading to increased defense against reactive oxygen species and higher resistance against TMZ treatment. Targeting this regulatory axis may help eliminate TMZ-resistant glioblastoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Endocrinology & Metabolism

Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

Wenxin Sha et al.

Summary: Ferroptosis is a novel form of cell death characterized by iron-dependent lipid peroxide accumulation and inadequate GPX4. It is ubiquitous in physiological and pathological processes, playing a role in the pathogenesis of diabetes.

JOURNAL OF DIABETES RESEARCH (2021)

Article Oncology

SLC7A11 negatively associates with mismatch repair gene expression and endows glioblastoma cells sensitive to radiation under low glucose conditions

Nan Hu et al.

Summary: The expression of SLC7A11 is higher in GBM compared to normal brain tissue, but is negatively associated with tumor grades and positively impacts survival. Overexpression of SLC7A11 in GBM cells reduces MMR gene expression, leading to increased sensitivity to radiation treatment. This suggests that SLC7A11 may be a potential biomarker for predicting a better response to radiotherapy in GBM.

NEOPLASMA (2021)

Review Oncology

Targeting ferroptosis in pancreatic cancer: a double-edged sword

Xin Chen et al.

Summary: PDAC is an aggressive malignancy with a poor response to current treatments, and ferroptosis may be a promising therapeutic target. Understanding the role and regulatory mechanisms of ferroptosis could lead to more effective treatment designs.

TRENDS IN CANCER (2021)

Article Medicine, General & Internal

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells

Qingxin Song et al.

Summary: The study found that temozolomide may partially inhibit glioblastoma cell growth by inducing ferroptosis, targeting DMT1 expression.

YONSEI MEDICAL JOURNAL (2021)

Article Multidisciplinary Sciences

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

Erdem M. Terzi et al.

Summary: Intracellular iron levels are strictly regulated to avoid iron-mediated ROS production. Loss of ISC synthesis can activate IRP2 independently of IRP1 and FBXL5, promoting ferroptosis sensitivity. Deletion of both IRP1 and IRP2 abolishes the iron-starvation response, preventing its activation by ISC synthesis inhibition.

SCIENCE ADVANCES (2021)

Review Biochemistry & Molecular Biology

Ferroptosis: mechanisms and links with diseases

Hong-fa Yan et al.

Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Oncology

Blockade of Glutathione Metabolism in IDH1-Mutated Glioma

Xiaoying Tang et al.

MOLECULAR CANCER THERAPEUTICS (2020)

Review Pharmacology & Pharmacy

Immunotherapy for Malignant Glioma: Current Status and Future Directions

Hongxiang Wang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

Article Biochemistry & Molecular Biology

Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition

Renxin Yi et al.

BIOSCIENCE REPORTS (2020)

Review Oncology

Immunotherapy for glioma: Current management and future application

Shengchao Xu et al.

CANCER LETTERS (2020)

Editorial Material Biochemistry & Molecular Biology

SnapShot: Ferroptosis

Kamyar Hadian et al.

Article Multidisciplinary Sciences

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

Di Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Arsenic trioxide as a novel anti-glioma drug: a review

Yi Fang et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2020)

Review Medicine, Research & Experimental

The cardinal roles of ferroportin and its partners in controlling cellular iron in and out

Qiuyuan Yang et al.

LIFE SCIENCES (2020)

Article Multidisciplinary Sciences

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Hyewon Kong et al.

SCIENCE ADVANCES (2020)

Article Biotechnology & Applied Microbiology

Quantitative characterization of the regulation of iron metabolism in glioblastoma stem-like cells using magnetophoresis

Kyoung-Joo J. Park et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Biotechnology & Applied Microbiology

Engineered immune cells as highly sensitive cancer diagnostics

Amin Aalipour et al.

NATURE BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Chaperone-mediated autophagy is involved in the execution of ferroptosis

Zheming Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

Review Chemistry, Multidisciplinary

Combining Nanomedicine and Immunotherapy

Yang Shi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

Cristina Florean et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Multidisciplinary Sciences

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang et al.

NATURE (2019)

Editorial Material Cell Biology

A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System

Brent R. Stockwell et al.

CELL METABOLISM (2019)

Article Nanoscience & Nanotechnology

Delivery luteolin with folacin-modified nanoparticle for glioma therapy

Cong Wu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Neurosciences

DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

Rosaria Ingrassia et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

Naroa Kajarabille et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll et al.

NATURE (2019)

Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

Article Genetics & Heredity

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS

Amanda Dobbyn et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2018)

Article Pharmacology & Pharmacy

Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

M. J. Ramalho et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Review Oncology

Current state of immunotherapy for glioblastoma

Michael Lim et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Multidisciplinary Sciences

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

Yuhan Chen et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Ron Shah et al.

ACS CENTRAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity

Xinxin Song et al.

CURRENT BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier

Martina Da Ros et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

The p53 Pathway in Glioblastoma

Ying Zhang et al.

CANCERS (2018)

Article Biochemistry & Molecular Biology

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

Daiha Shin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Multidisciplinary Sciences

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Wout Oosterheert et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation

Takeo Goji et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Medicine, Research & Experimental

PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

Moon-Suhn Ryu et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Chemistry, Multidisciplinary

Defect-Induced Near-Infrared Photoluminescence of Single-Walled Carbon Nanotubes Treated with Polyunsaturated Fatty Acids

Cheuk Fai Chiu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Biochemistry & Molecular Biology

Dietary iron loading negatively affects liver mitochondrial function

Chiara Volani et al.

METALLOMICS (2017)

Review Cell & Tissue Engineering

Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications

Eunice Yuen-Ting Lau et al.

STEM CELLS INTERNATIONAL (2017)

Review Oncology

The impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells

Alessandra Audia et al.

FRONTIERS IN ONCOLOGY (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy

Gladys O. Latunde-Dada

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Review Biochemistry & Molecular Biology

Mechanisms of ferroptosis

Jennifer Yinuo Cao et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Neurosciences

The role of microglia and macrophages in glioma maintenance and progression

Dolores Hambardzumyan et al.

NATURE NEUROSCIENCE (2016)

Article Medicine, Research & Experimental

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Konrad Gabrusiewicz et al.

JCI INSIGHT (2016)

Review Clinical Neurology

Transferrin receptors and glioblastoma multiforme: Current findings and potential for treatment

Brittany Voth et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2015)

Article Biochemistry & Molecular Biology

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

Esperanza Arias et al.

MOLECULAR CELL (2015)

Review Respiratory System

Candidate genes for COPD: current evidence and research

Woo Jin Kim et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Article Clinical Neurology

Evolution of Malignant Glioma Treatment

Richard Lee Price et al.

NEUROSURGERY (2014)

Article Pharmacology & Pharmacy

Transferrin modified PEG-PLA-resveratrol conjugates: In vitro and in vivo studies for glioma

Wanhua Guo et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

Review Cell Biology

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

Melba C. Jaramillo et al.

GENES & DEVELOPMENT (2013)

Article Medicine, Research & Experimental

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3

Wei Han et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Hematology

Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses

Fan Zhang et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)

Review Oncology

Recent advances in the molecular understanding of glioblastoma

Fonnet E. Bleeker et al.

JOURNAL OF NEURO-ONCOLOGY (2012)

Article Multidisciplinary Sciences

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

Masahisa Jinushi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Oncology

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

Suzanne Ostrand-Rosenberg

CANCER IMMUNOLOGY IMMUNOTHERAPY (2010)

Article Biochemistry & Molecular Biology

The unusual amino acid L-ergothioneine is a physiologic cytoprotectant

B. D. Paul et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

Role of hepcidin in murine brain iron metabolism

S. -M. Wang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Gastroenterology & Hepatology

CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice

Kyoung Moo Choi et al.

GASTROENTEROLOGY (2010)

Article Oncology

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study

Michael T. Milano et al.

JOURNAL OF NEURO-ONCOLOGY (2010)

Article Chemistry, Multidisciplinary

The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies

Jin Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Oncology

Transferrin Receptor 2 Is Frequently and Highly Expressed in Glioblastomas

Alessia Calzolari et al.

TRANSLATIONAL ONCOLOGY (2010)

Article Neurosciences

Expression of iron-related genes in human brain and brain tumors

Milla M. Hanninen et al.

BMC NEUROSCIENCE (2009)

Review Immunology

How regulatory T cells work

Dario A. A. Vignali et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Cell Biology

Expression and function of cystine/glutamate transporter in neutrophils

Yuki Sakakura et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Hematology

The Steap proteins are metalloreductases

Robert S. Ohgami et al.

Review Clinical Neurology

Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

H Ohgaki et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)

Article Oncology

Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles

SCJ Steiniger et al.

INTERNATIONAL JOURNAL OF CANCER (2004)