期刊
ANTIOXIDANTS
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/antiox11112123
关键词
glioma; ferroptosis; lipid peroxidation; molecular mechanisms; treatment
资金
- National Natural Science Foundation of China [81960541/82060455]
Glioma is a common intracranial malignant tumor and current treatment options are not very effective. Recently, a new form of cell death called ferroptosis has been discovered, which plays a significant role in the treatment of gliomas.
Glioma is the most common intracranial malignant tumor, and the current main standard treatment option is a combination of tumor surgical resection, chemotherapy and radiotherapy. Due to the terribly poor five-year survival rate of patients with gliomas and the high recurrence rate of gliomas, some new and efficient therapeutic strategies are expected. Recently, ferroptosis, as a new form of cell death, has played a significant role in the treatment of gliomas. Specifically, studies have revealed key processes of ferroptosis, including iron overload in cells, occurrence of lipid peroxidation, inactivation of cysteine/glutathione antiporter system Xc(-) (xCT) and glutathione peroxidase 4 (GPX4). In the present review, we summarized the molecular mechanisms of ferroptosis and introduced the application and challenges of ferroptosis in the development and treatment of gliomas. Moreover, we highlighted the therapeutic opportunities of manipulating ferroptosis to improve glioma treatments, which may improve the clinical outcome.
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