Continuous Glucose Monitoring in Preterm Infants: The Role of Nutritional Management in Minimizing Glycemic Variability

Article Pediatrics

Adenosine Blood Level: A Biomarker of White Matter Damage in Very Low Birth Weight Infants

Marina Colella et al.

Summary: The study suggests that blood adenosine concentration may serve as a biomarker for cerebral white matter lesions in very low birth weight infants, with levels correlating with lesion development and neurodevelopmental outcomes.

CURRENT PEDIATRIC REVIEWS (2022)

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Article Endocrinology & Metabolism

Addition of intermittently scanned continuous glucose monitoring to standard care in a cohort of pregnant women with type 1 diabetes: effect on glycaemic control and pregnancy outcomes

Veronica Perea et al.

Summary: The study found that pregnant women with type 1 diabetes using isCGM had lower HbA(1c) levels in the second trimester compared to those using SMBG, but there were no significant differences between the groups in the third trimester. Furthermore, newborns of isCGM users were more likely to experience neonatal hypoglycaemia compared to non-sensor users, although rates of macrosomia and prematurity were similar.

DIABETOLOGIA (2022)

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Article Endocrinology & Metabolism

Continuous Glucose Monitoring in the Management of Neonates With Persistent Hypoglycemia and Congenital Hyperinsulinism

Myat Win et al.

Summary: This retrospective study introduces the use of real-time CGM in monitoring persistent neonatal hypoglycemia. The study found significant fluctuations in glucose levels in babies with congenital hyperinsulinism, highlighting the challenges of preventing hypoglycemia. The results also suggest the potential application of CGM as an adjunct to clinical care in managing neonatal hypoglycemia.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Chemistry, Analytical

Wearable hydrogel patch with noninvasive, electrochemical glucose sensor for natural sweat detection

Pei-Heng Lin et al.

Summary: Recent advances in microelectronics and electrochemical sensing platforms have enabled the development of a wearable, noninvasive sweat glucose sensor with convenient hydrogel patches. This sensor can rapidly sample natural perspiration without the need for external activities that stimulate sweating. By utilizing an electrochemical sensing method, the sensor provides cost-effective and accurate measurements of glucose levels in sweat. The sweat glucose sensor shows great promise for clinical-grade glucose management during routine and sedentary activities, expanding the possibilities for next-generation noninvasive sensing systems.

TALANTA (2022)

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Review Chemistry, Multidisciplinary

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Vundrala Sumedha Reddy et al.

Summary: Biosensors have the potential to revolutionize the biomedical field due to their portability, cost-effectiveness, and ease of operation. Diabetes mellitus, a common condition leading to deaths worldwide, can be detected using biosensors in various biological fluids such as blood, urine, and sweat. This literature review provides an update on recent advances in biofluid-based sensors for glucose level detection.

NANOMATERIALS (2022)

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Article Pediatrics

Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial

Kathryn Beardsall et al.

Summary: The study found that using real-time continuous glucose monitoring can reduce the risk of prolonged or severe hyperglycaemia and hypoglycaemia in preterm infants. Further research is needed to determine optimal glucose targets, strategies to achieve them, and the potential impact on long-term health outcomes.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Preterm Newborns

Chiara Lembo et al.

Summary: Preterm babies are vulnerable to oxidative stress due to an imbalance between oxidant and antioxidant systems, leading to oxidative damage and various diseases. Biomarkers can help identify newborns at risk of free radical-mediated diseases early on, leading to the development of new antioxidant strategies for prevention and treatment.

ANTIOXIDANTS (2021)

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Review Endocrinology & Metabolism

Neonatal Hypoglycemia and Brain Vulnerability

Laura Costanza De Angelis et al.

Summary: Neonatal hypoglycemia is common and usually resolves within the first 48 to 72 hours of life. Severe and prolonged hypoglycemia is associated with cerebral damage, potentially leading to neuronal injury.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Nutrition & Dietetics

Early Enteral Feeding in Preterm Infants: A Narrative Review of the Nutritional, Metabolic, and Developmental Benefits

Melissa Thoene et al.

Summary: This article discusses the preferred method of nutrient provision for preterm infants and the benefits of early enteral feeding in enhancing nutrient delivery and promoting development. It also suggests methods to improve clinical enteral delivery and highlights the impact of early enteral feeding on preterm infant health, including enhancing micronutrient delivery, promoting intestinal and brain development, and reducing inflammation.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Effects of early energy intake on neonatal cerebral growth of preterm newborn: an observational study

Giovanni Boscarino et al.

Summary: The mode of early energy intake in preterm newborns has different effects on cerebral growth. High energy intake administered through enteral nutrition is positively correlated with cerebral growth, while parenteral nutrition energy intake results in poorer cerebral growth evaluated with cranial Ultrasonography.

SCIENTIFIC REPORTS (2021)

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Review Pediatrics

Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology

Kathryn Beardsall

Summary: Hyperglycemia is common in newborns requiring intensive care, particularly in preterm infants, in sepsis and following perinatal hypoxia. The optimal intervention strategy varies with context and controversial due to limited evidence, with careful consideration needed to ascertain potentially treatable causes and manage glucose levels effectively.

FRONTIERS IN PEDIATRICS (2021)

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Article Pediatrics

Impacts of Hypoglycemia in At-Risk Infants on Admissions to Level-3 Neonatal Units in a Tertiary-Care Hospital

Hala Alasaad et al.

Summary: The study reveals a high prevalence of low glucose readings in level-1 postnatal units, necessitating clinical observation and regular monitoring for at-risk infants.

RESEARCH AND REPORTS IN NEONATOLOGY (2021)

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Article Pediatrics

Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring

Lynn Thomson et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2019)

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Article Obstetrics & Gynecology

Real time continuous glucose monitoring in neonatal intensive care

Kathryn Beardsall

EARLY HUMAN DEVELOPMENT (2019)

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Article Neurosciences

Early Pain Exposure Influences Functional Brain Connectivity in Very Preterm Neonates

Domenico Tortora et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Nutrition & Dietetics

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Carbohydrates

D. Mesotten et al.

CLINICAL NUTRITION (2018)

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Review Endocrinology & Metabolism

Intermittent versus continuous feeding in critically ill adults

Jayshil J. Patel et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2018)

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Review Pediatrics

Neonatal hypoglycemia: continuous glucose monitoring

Rajesh Shah et al.

CURRENT OPINION IN PEDIATRICS (2018)

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Article Pediatrics

Procedural Pain during Insertion of a Continuous Glucose Monitoring Device in Preterm Infants

Alfonso Galderisi et al.

JOURNAL OF PEDIATRICS (2018)

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Article Endocrinology & Metabolism

Defining Glycemic Variability in Very Low-Birthweight Infants: Data from a Continuous Glucose Monitoring System

Mateusz Jagla et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2018)

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Review Nursing

Neonatal Hypoglycemia Is There a Sweet Spot?

Mary L. Puchalski et al.

CRITICAL CARE NURSING CLINICS OF NORTH AMERICA (2018)

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Review Pediatrics

Oxidative Stress as a Primary Risk Factor for Brain Damage in Preterm Newborns

Isabella Panfoli et al.

FRONTIERS IN PEDIATRICS (2018)

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Article Pediatrics

Relationship between Measures of Neonatal Glycemia, Neonatal Illness, and 2-Year Outcomes in Very Preterm Infants

Anna Catherine Tottman et al.

JOURNAL OF PEDIATRICS (2017)

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Article Pediatrics

Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial

Alfonso Galderisi et al.

PEDIATRICS (2017)

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Article Pediatrics

Association of Neonatal Glycemia With Neurodevelopmental Outcomes at 4.5 Years

Christopher J. D. McKinlay et al.

JAMA PEDIATRICS (2017)

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Article Cardiac & Cardiovascular Systems

Acute blood glucose fluctuation enhances rat aorta endothelial cell apoptosis, oxidative stress and pro-inflammatory cytokine expression in vivo

Na Wu et al.

CARDIOVASCULAR DIABETOLOGY (2016)

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Article Pediatrics

Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

Marine Bouyssi-Kobar et al.

PEDIATRICS (2016)

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Article Pediatrics

Intraday glucose fluctuation is common in preterm infants receiving intermittent tube feeding

Hiroshi Mizumoto et al.

PEDIATRICS INTERNATIONAL (2016)

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Article Gastroenterology & Hepatology

Intermittent Bolus or Semicontinuous Feeding for Preterm Infants?

Lyanne W. W. Rovekamp-Abels et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2015)

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Article Pediatrics

Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children

Paul S. Thornton et al.

JOURNAL OF PEDIATRICS (2015)

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Article Obstetrics & Gynecology

Different gestational ages and changing vulnerability of the premature brain

Andrea Sannia et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2015)

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Article Multidisciplinary Sciences

Real-Time Continuous Glucose Monitoring Reduces the Duration of Hypoglycemia Episodes: A Randomized Trial in Very Low Birth Weight Neonates

Florence Uettwiller et al.

PLOS ONE (2015)

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Article Pediatrics

Validation of the continuous glucose monitoring sensor in preterm infants

K. Beardsall et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2013)

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Article Pediatrics

Hyperglycemia increases the risk of death in extremely preterm baboons

Cynthia L. Blanco et al.

PEDIATRIC RESEARCH (2013)

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Article Multidisciplinary Sciences

Neonatal Pain-Related Stress Predicts Cortical Thickness at Age 7 Years in Children Born Very Preterm

Manon Ranger et al.

PLOS ONE (2013)

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Article Obstetrics & Gynecology

Higher glycemic variability in very low birth weight newborns is associated with greater early neonatal mortality

Wojciech Fendler et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2012)

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Article Critical Care Medicine

Glucose variability is associated with intensive care unit mortality

Jeroen Hermanides et al.

CRITICAL CARE MEDICINE (2010)

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Editorial Material Pediatrics

Continuous Glucose Monitoring for Diagnosis and Treatment of Neonatal Hypoglycemia

William W. Hay et al.

JOURNAL OF PEDIATRICS (2010)

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Article Pediatrics

Continuous Glucose Monitoring in Newborn Babies at Risk of Hypoglycemia

Deborah L. Harris et al.

JOURNAL OF PEDIATRICS (2010)

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Article Pediatrics

Early Hyperglycemia Is a Risk Factor for Death and White Matter Reduction in Preterm Infants

Georgios Alexandrou et al.

PEDIATRICS (2010)

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Review Pediatrics

Strategies for Feeding the Preterm Infant

William W. Hay

NEONATOLOGY (2008)

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Article Obstetrics & Gynecology

Glucose metabolism in the late preterm infant

Meena Garg et al.

CLINICS IN PERINATOLOGY (2006)

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Article Pediatrics

Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants

Stephane P. Hays et al.

PEDIATRICS (2006)

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Article Medicine, General & Internal

Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic Hyperglycemia in patients with type 2 diabetes

L Monnier et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

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Review Pediatrics

Hypoglycemia in newborn infants: Features associated with adverse outcomes

Paul J. Rozance et al.

BIOLOGY OF THE NEONATE (2006)

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Article Pediatrics

Continuous feeding promotes gastrointestinal tolerance and growth in very low birth weight infants

A Dsilna et al.

JOURNAL OF PEDIATRICS (2005)

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Article Pediatrics

Both relative insulin resistance and defective islet β-cell processing of proinsulin are responsible for transient hyperglycemia in extremely preterm infants

D Mitanchez-Mokhtari et al.

PEDIATRICS (2004)

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Review Obstetrics & Gynecology

Hypoglycemia in the neonate

M Cornblath et al.

SEMINARS IN PERINATOLOGY (2000)

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Review Obstetrics & Gynecology

Hypoglycemia: What is it for the neonate?

S Kalhan et al.

AMERICAN JOURNAL OF PERINATOLOGY (2000)

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Continuous Glucose Monitoring in Preterm Infants: The Role of Nutritional Management in Minimizing Glycemic Variability

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