期刊
ANTIOXIDANTS
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/antiox11101945
关键词
continuous glucose monitoring; glycemic variability; enteral feeding; preterm infants
资金
- SFPREMAC 2021 [PR19721/21]
Glycemic variability is common in preterm infants and can affect neurodevelopment. This study found that intermittent enteral feeding is better for glycemic control compared to continuous feeding. Optimizing nutritional management is crucial for the long-term health of preterm infants.
Glycemic variability (GV) is common in preterm infants. In the premature population, GV is a risk factor for morbidity and mortality. Both hypo- and hyperglycemia can impair neurodevelopment. We investigated the impact of continuous versus intermittent tube enteral feeding on GV. In our prospective observational study, 20 preterm infants with a gestational age <= 34 weeks at either continuous or intermittent bolus full enteral feeding. For five days, continuous glucose monitoring (CGM) was utilized, which was achieved through the subcutaneous insertion of a sensor. A total of 27,532 measurements of blood glucose were taken. The mean amplitude of glycemic excursions did not differ between the two cohorts statistically. Continuous feeding resulted in higher positive values, increasing the risk of hypo- and hyperglycemia. Subjects who were small for their gestational age had a higher standard deviation during continuous feeding (p = 0.001). Data suggest that intermittent bolus nutrition is better for glycemic control than continuous nutrition. Nutritional management optimization of preterm infants appears to be critical for long-term health. In the future, CGM may provide a better understanding of the optimal glucose targets for various clinical conditions, allowing for a more personalized approach to management.
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