Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

Article Biochemistry & Molecular Biology

Association Between Essential and Non-essential Metals, Body Composition, and Metabolic Syndrome in Adults

Yi Jing Ngu et al.

Summary: The study found that exposure to essential metals may affect body composition and metabolic profiles, exacerbating the risk of metabolic syndrome.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

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Article Environmental Sciences

Associations between multiple heavy metals exposure and glycated hemoglobin in a Chinese population

Jiansheng Cai et al.

Summary: Copper was positively correlated with HbA1c, while nickel was negatively correlated with HbA1c, whether evaluated individually or in a metal mixture. The effects of copper and nickel on HbA1c varied by sex, age, and smoking status. Overall, the plasma metal mixtures did not show a significant impact on HbA1c.

CHEMOSPHERE (2022)

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Article Environmental Sciences

The association between urine elements and fasting glucose levels in a community-based elderly people in Beijing

Liu Liu et al.

Summary: This study investigated the associations between joint exposure to co-existing urinary elements and fasting blood glucose (FBG) levels in a cross-sectional design. The results showed that eight elements (Zn, Se, Fe, Cr, Ni, Cd, Mn, and Al) had a higher influence on FBG. Furthermore, Cd and Zn were found to have a significant association with FBG levels when other co-existing elements were controlled at different levels.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Understanding Cellular Redox Homeostasis: A Challenge for Precision Medicine

Verena Tretter et al.

Summary: The field of redox biology aims to understand the regulation and maintenance of redox homeostasis, as well as the mechanisms involved in the development of diseases with oxidative or reductive stress. Targeting oxidative stress therapeutically is challenging due to the delicate cellular redox systems that vary in concentrations across subcellular compartments and depend on the physiological and pathological status of cells and organelles.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Cross-sectional study: Relationship between serum trace elements and hypertension

Zhengduo Zhang et al.

Summary: Levels of serum trace elements show age- and sex-related differences in rural Chinese adults with hypertension and healthy participants. Serum concentrations of Cu, Se, and Cr may be independently associated with hypertension, while higher serum ratios of Cu:Zn and Mg:Mn may also be linked to hypertension. Further randomized trials are needed to clarify the true relationship between levels of Cu, Se, Cr, Cu:Zn, Mg:Mn, and hypertension.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2022)

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Article Environmental Sciences

Trace elements in whole blood in the general population in Trondelag County, Norway: The HUNT3 Survey

Anica Simic et al.

Summary: Analyzing whole blood samples from a population-based study in Norway, the study investigated the concentrations of 28 trace elements in the general population of the Nord-Trondelag region. Findings suggested low exposure to toxic trace elements in the region, with differences in concentrations related to geographical locations and individual lifestyle factors.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Nutrition & Dietetics

Manganese Exposure and Metabolic Syndrome: A Systematic Review and Meta-Analysis

Martin Ming Him Wong et al.

Summary: This review examines the association between dietary and environmental manganese exposure and the risk of metabolic syndrome (MetS). The findings suggest that the levels of manganese from diet, serum, urine, and whole blood do not have a significant association with MetS. However, some studies indicate a non-linear relationship between urinary and blood manganese levels and MetS, and higher dietary manganese may be associated with a lower MetS risk in certain studies.

NUTRIENTS (2022)

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Article Environmental Sciences

Powering Research through Innovative Methods for Mixtures in Epidemiology (PRIME) Program: Novel and Expanded Statistical Methods

Bonnie R. Joubert et al.

Summary: Humans are exposed to a variety of chemical and non-chemical mixtures throughout their lives, and it is important to investigate the health impacts of these mixtures. However, there are challenges in analyzing mixture data in epidemiological studies, such as high correlation among health and exposure measures, missing observations, violation of modeling assumptions, and computational challenges. The PRIME program aims to address these challenges by developing and expanding statistical methods for mixtures. This review summarizes new methods from PRIME projects and provides insights for method selection and application.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Nutrition & Dietetics

ESPEN micronutrient guideline

Mette M. Berger et al.

Summary: This guideline aims to provide information for daily clinical nutrition practice regarding assessment, monitoring, and prescription of micronutrients (MNs), and proposes a consensus terminology to reduce confusion.

CLINICAL NUTRITION (2022)

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Article Cardiac & Cardiovascular Systems

Effectiveness of the d-ROMs oxidative stress test to predict long-term cardiovascular mortality

Yasuhiro Hitomi et al.

Summary: This study found that the d-ROMs value in the blood is closely related to the prognosis of cardiovascular disease. Patients with a d-ROMs value of greater than or equal to 395 U.CARR have a higher risk of all-cause mortality, cardiovascular death, and major adverse cardiovascular events.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2022)

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Review Nutrition & Dietetics

Perspective: Role of Micronutrients and Omega-3 Long-Chain Polyunsaturated Fatty Acids for Immune Outcomes of Relevance to Infections in Older Adults-A Narrative Review and Call for Action

Manfred Eggersdorfer et al.

Summary: Prevention and treatment of age-related decline in immunity are crucial for successful aging. This Perspective summarizes the literature on nutrients and immunity and suggests a novel integrative approach of providing recommended nutrients in combination to maximize their effects.

ADVANCES IN NUTRITION (2022)

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Article Public, Environmental & Occupational Health

The Association Between Plasma Copper Concentration and Prevalence of Diabetes in Chinese Adults With Hypertension

Zhixin Cui et al.

Summary: In Chinese hypertensive adults with serum HDL-C concentration >= 1.2 mmol/L, high plasma copper concentration (>= 109.4 mu g/dL) was associated with increased prevalence of diabetes.

FRONTIERS IN PUBLIC HEALTH (2022)

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Article Biology

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Cristina Sanchez-Gonzalez et al.

Summary: The study found that diabetes alters the metabolism of zinc, copper, and manganese, and treatment with vanadium(IV) can reverse the changes in zinc and copper homeostasis caused by hyperglycemia. This effect is possibly mediated by a decrease in DMT1 gene expression.

BIOLOGY-BASEL (2022)

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Review Environmental Sciences

Exposure to Metal Mixtures in Association with Cardiovascular Risk Factors and Outcomes: A Scoping Review

Gyeyoon Yim et al.

Summary: This scoping review summarizes the literature on the cardiotoxicity of exposure to metal mixtures and identifies the trends and focus areas in the research. The majority of the studies were conducted in the United States and China, with an increase in publications in recent years. The commonly investigated metals included cadmium, lead, arsenic, and cobalt, with a focus on their impact on blood pressure, preeclampsia, dyslipidemia, and cardiovascular disease outcomes.

TOXICS (2022)

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Article Cardiac & Cardiovascular Systems

Body iron stores had no impact on coronary heart disease outcomes: a middle-aged male cohort from the general population with 21-year follow-up

Salim Bary Barywani et al.

Summary: This study found no significant association between serum ferritin or serum transferrin receptor as markers of BIS and CHD events in middle-aged men after 21 years of follow-up.

OPEN HEART (2022)

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Article Nutrition & Dietetics

Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Kati Karberg et al.

Summary: This study aimed to evaluate the correlation between subclinical atherosclerosis and the dietary zinc to copper ratio (Zn:Cu) and the relationship between Zn:Cu and the dietary pattern of patients with type 2 diabetes mellitus (T2DM). The study found that a high dietary Zn:Cu ratio in T2DM patients was significantly associated with worse carotid artery IMT. Zinc supplementation may aggravate cardiovascular morbidity.

CLINICAL NUTRITION ESPEN (2022)

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Review Nutrition & Dietetics

Dietary Selenium Across Species

Xin Gen Lei et al.

Summary: This review article discusses the discovery of selenium as an essential nutrient and provides a comprehensive analysis of its dietary sources, metabolic functions, and requirements across various species. It also addresses the metabolic impacts of high dietary selenium intakes and the cycling of selenium in food systems and ecosystems.

ANNUAL REVIEW OF NUTRITION (2022)

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Review Environmental Sciences

A review of practical statistical methods used in epidemiological studies to estimate the health effects of multi-pollutant mixture

Linling Yu et al.

Summary: Environmental risk factors have adverse effects on health. Previous studies mainly focused on the impact of single pollutant exposure, but in reality, humans are exposed to complex mixtures of pollutants. Environmental epidemiologists have been trying to assess the health effects of exposure to multi-pollutant mixtures, but statistical analysis faces challenges. There is currently no consensus on appropriate statistical methods.

ENVIRONMENTAL POLLUTION (2022)

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Article Environmental Sciences

Exposure to metal mixtures and hypertensive disorders of pregnancy: A nested case-control in China*

Jiaolong Ma et al.

Summary: This study investigated the impact of exposure to metal mixtures on the risk of hypertensive disorders of pregnancy (HDP). The findings suggest that exposure to metal mixtures in early pregnancy is associated with an increased risk of HDP. There may also be a potential interaction between aluminum and vanadium in influencing the risk of HDP.

ENVIRONMENTAL POLLUTION (2022)

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Article Nutrition & Dietetics

Trends in Overall and Micronutrient-Containing Dietary Supplement Use in US Adults and Children, NHANES 2007-2018

Alexandra E. Cowan et al.

Summary: This study examined the use of dietary supplements (DS) in the US population from 2007-2018 using multiple assessment methods. The results showed an increase in the prevalence of DS use as well as micronutrient-containing DS use over time. The use of single-nutrient DS increased, while the use of multivitamin-mineral DS decreased. Different population subgroups showed variations in DS use.

JOURNAL OF NUTRITION (2022)

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Article Biochemistry & Molecular Biology

The impact of essential and toxic elements on cardiometabolic risk factors in adults and older people

Francisca Leide da Silva Nunes et al.

Summary: This study investigates the concentrations of essential and toxic elements in urine and plasma and their relationship with cardiometabolic risk factors. The results indicate that these elements could potentially serve as biomarkers for cardiovascular risk factors. It emphasizes the importance of adopting a healthy lifestyle and implementing government policies for sustainable production and a safe environment.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Catherine Tcheandjieu et al.

Summary: This study incorporates a diverse cohort of individuals to explore the genetic landscape of coronary artery disease. The researchers discovered novel loci associated with the disease in different ancestral groups, and identified common haplotypes that contribute to risk stratification. They also found genetic overlaps between coronary artery disease and clinical coronary atherosclerosis, and related these genetic factors to insulin resistance and other traits.

NATURE MEDICINE (2022)

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Article Medicine, Research & Experimental

Albumin-corrected Zn and available free Zn-binding capacity as indicators of Zn status - potential for clinical implementation

Louise H. Jorgensen et al.

Summary: This article presents two measurement procedures for diagnosing zinc deficiency, namely albumin-corrected zinc concentration and available free zinc-binding capacity. The results reveal a risk of overdiagnosing zinc deficiency based on low plasma zinc concentrations, and suggest that unnecessary zinc supplementation can be avoided by using albumin-corrected zinc concentration or available free zinc-binding capacity.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2022)

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Article Nutrition & Dietetics

The Perception of Minerals and Their Prevalence in Fortified Foods and Supplements in Japan

Tsuyoshi Chiba et al.

Summary: People's intake of some minerals falls short of the recommended values, and zinc and/or selenium deficiencies are considered to increase the risk and severity of COVID-19 infection. Calcium has the highest level of awareness, while selenium has the lowest. Only a small portion of people believe they consume enough of each mineral. Some individuals feel unable to consume sufficient sodium, despite excessive intake by most of the population. The use of mineral-fortified foods and/or supplements aims to maintain health, supplement nutrients, and prevent infectious diseases. Only a few participants know the amount of minerals they consume.

NUTRIENTS (2022)

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Article Endocrinology & Metabolism

Associations of Dietary Antioxidants with Glycated Hemoglobin and Insulin Sensitivity in Adults with and without Type 1 Diabetes

Arpita Basu et al.

Summary: This study aimed to investigate the association between dietary micronutrients and glycemic status. The results showed that higher dietary manganese intake was associated with higher insulin sensitivity in individuals with type 1 diabetes, while higher dietary copper intake was associated with higher HbA1c levels. These findings highlight the importance of trace elements in glycemic control in both diabetic and non-diabetic populations.

JOURNAL OF DIABETES RESEARCH (2022)

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Article Nutrition & Dietetics

Combined Exposure to 33 Trace Elements and Associations With the Risk of Oral Cancer: A Large-Scale Case-Control Study

Huiying Wang et al.

Summary: This study comprehensively evaluated the independent and joint effects of 33 trace elements on oral cancer risk. It found that the overall mixture effect of essential and non-essential elements might be associated with oral cancer risk. Serum levels of zinc, vanadium, copper, strontium, selenium, thorium, lithium, and yttrium were identified as potential risk factors. Further studies are needed to confirm these findings.

FRONTIERS IN NUTRITION (2022)

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Article Nutrition & Dietetics

Association of zinc serum level with metabolic syndrome in iranian children and adolescents: The CASPIAN-V study

Mostafa Qorbani et al.

Summary: Metabolic syndrome comprises a set of metabolic risk factors associated with cardiovascular disease and type 2 diabetes. Zinc plays an essential role in numerous enzyme functions that may be associated with metabolic dysfunctions. This study found no association between serum zinc levels and metabolic syndrome in children, suggesting the need for further research with larger sample sizes to reveal the exact relationship.

FRONTIERS IN NUTRITION (2022)

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Article Environmental Sciences

Human biomonitoring survey (Pb, Cd, As, Cu, Zn, Mo) for urban gardeners exposed to metal contaminated soils

Jerome C. J. Petit et al.

Summary: This study investigated the exposure levels of trace metals and metalloids among a group of gardeners in an allotment garden, and found high concentrations of lead, cadmium, and arsenic in their blood and urine samples, which were higher than those of the local population living on contaminated soils. The study suggests that these gardeners are at risk of chronic kidney diseases due to co-exposure and additive effects of these contaminants.

ENVIRONMENTAL POLLUTION (2022)

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Article Environmental Sciences

Multi-matrix biomonitoring approach to assess exposure to metals and trace elements in the Lebanese population and associations with drinking water consumption

Nessrine Nasser Eddine et al.

Summary: This study is the first attempt to assess exposure to metals and trace elements in subgroups of the Lebanese population using a multi-matrix biomonitoring approach. The results highlight the importance of paying special attention to metal and trace element exposure in this population, and further conducting a large-scale human biomonitoring initiative to generalize results and assess trends over time.

ENVIRONMENTAL RESEARCH (2022)

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Article Environmental Sciences

Individual and joint associations of co-exposure to multiple plasma metals with telomere length among middle-aged and older Chinese in the Dongfeng-Tongji cohort

Xuefeng Lai et al.

Summary: This study provides a comprehensive view of the associations between metals and white blood cell telomere length (LTL). It found that certain metals were negatively associated with LTL, while others were positively associated. Additionally, the associations of vanadium, aluminum, manganese, and metal mixture with LTL were more prominent in overweight participants.

ENVIRONMENTAL RESEARCH (2022)

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Review Cell Biology

Role of Iron-Related Oxidative Stress and Mitochondrial Dysfunction in Cardiovascular Diseases

Fang Yan et al.

Summary: Iron is crucial in various biological processes, but its abnormal regulation and accumulation can contribute to pathological processes in cardiovascular diseases. This review summarizes the pathological roles of iron-related oxidative stress in cardiovascular diseases and highlights the potential effects and mechanisms of mitochondrial iron homeostasis and dysfunction in these diseases.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Multidisciplinary Sciences

Pharmacogenomics polygenic risk score for drug response prediction using PRS-PGx methods

Song Zhai et al.

Summary: This article introduces a pharmacogenomics-specific polygenic risk score (PRS) method that can improve drug response prediction and patient stratification. By simultaneously modeling both the prognostic and predictive effects of genetic variants, the proposed approach outperforms traditional disease PRS methods.

NATURE COMMUNICATIONS (2022)

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Article Medicine, General & Internal

Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population

Eva M. Asensio et al.

Summary: This study analyzed the association between genetic variants related to the gut microbiome and fasting glucose and type 2 diabetes in a Mediterranean population. The study found interesting associations and interactions with adherence to the Mediterranean diet, suggesting potential new hypotheses. The use of genetic variants as proxies for the microbiome is still in its early stages, but shows promise for future research.

MEDICINA-LITHUANIA (2022)

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Review Ophthalmology

Association of keratoconus with serum levels of 25-hydroxyvitamin D and antioxidant trace elements: A systematic review and meta-analysis

Parul C. Gupta et al.

Summary: The aim of this study was to summarize and compare the levels of vitamin D and antioxidant trace elements in keratoconus (KC) patients and healthy controls. The results showed that KC patients had significantly lower serum levels of vitamin D, zinc, and selenium compared to the control group. The decrease in serum vitamin D level was greater in progressive patients compared to stable patients. Regular evaluation of these markers could be valuable in predicting disease progression and severity in KC patients.

INDIAN JOURNAL OF OPHTHALMOLOGY (2022)

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Article Environmental Sciences

Association between blood metals mixtures concentrations and cognitive performance, and effect modification by diet in older US adults

Nasser Laouali et al.

Summary: Chronic exposure to heavy metals has been found to be associated with adverse neurological outcomes in older adults. Inflammatory processes may play a role in the neurotoxic effects of metals, while a diet rich in antioxidants and anti-inflammatory components could potentially protect against chronic inflammation. This study examined the associations between blood concentrations of lead, cadmium, and manganese as a mixture and cognitive performance in older US adults, and also explored the potential modifying effects of diet on these associations. The findings suggest that adherence to an antioxidant and anti-inflammatory diet may prevent the cognitive effects of blood metals in older adults, with variations observed by sex and diet quality.

ENVIRONMENTAL EPIDEMIOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Role of Selenium in Pathologies: An Updated Review

Giulia Barchielli et al.

Summary: Selenium is an essential microelement involved in various biological functions and plays a role in preventing and modulating several diseases. Adequate selenium nutrition and supplementation can improve prognosis and reduce disease risk.

ANTIOXIDANTS (2022)

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Article Environmental Sciences

Measurement harmonization and traceability for trace element analyses across the Children 's Health Exposure Analysis Resource laboratory network

Aubrey L. Galusha et al.

Summary: CHEAR laboratories ensured harmonization of trace element measurements through methods such as interlaboratory validation exercises, participation in proficiency programs, and analysis of common reference materials. Over a 5-year period, performance among laboratories improved, with over 99% of challenges for urine trace elements and 95% for whole blood trace elements found to be satisfactory in 2018-2019.

ENVIRONMENTAL RESEARCH (2021)

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Article Nutrition & Dietetics

Dietary Selenium Intake and Type-2 Diabetes: A Cross-Sectional Population-Based Study on CUME Project

Joao Pedro Viana Dias et al.

Summary: The study investigated the association between dietary selenium intake and type-2 diabetes in a Brazilian cohort, finding no significant link between selenium intake and the prevalence of type-2 diabetes. This contradicts previous studies and suggests a controversial relationship.

FRONTIERS IN NUTRITION (2021)

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Article Pediatrics

Micronutrient status and associated factors of adiposity in primary school children with normal and high body fat in Colombo municipal area, Sri Lanka

Kalaichelvi Thillan et al.

Summary: The study revealed that children with high body fat have higher socioeconomic status, spend less time on physical activities, engage in more sedentary behaviors, consume higher energy, and have inconsistent distribution of micronutrients. Increased levels of inflammatory markers indicate the presence of the risk of chronic inflammation in children with high body fat.

BMC PEDIATRICS (2021)

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Article Environmental Sciences

Correlation between urinary contents of some metals and fasting plasma glucose levels: A cross-sectional study in China

Xiaoting Mo et al.

Summary: This study found that multiple metals in urine are associated with fasting plasma glucose levels, with zinc, selenium, and strontium showing significant correlation. The mixture of metals has a positive overall effect on glucose levels, with zinc contributing the most. Further studies are needed to confirm these findings and understand the underlying mechanisms.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Environmental Sciences

Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults

Limei Shi et al.

Summary: This study found that several plasma metals/metalloids were key determinants and predictors of all-cause and CVD death in the Chinese population. The findings highlighted the importance of comprehensively assessing and monitoring multiple metals/metalloids exposures.

ENVIRONMENT INTERNATIONAL (2021)

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Article Environmental Sciences

Human biomonitoring of toxic and essential metals in younger elderly, octogenarians, nonagenarians and centenarians: Analysis of the Healthy Ageing and Biomarkers Cohort Study (HABCS) in China

Yuebin Lv et al.

Summary: The study investigated the concentrations of toxic metals and essential metals in longevity among elderly individuals of different age groups. Men had higher concentrations of toxic metals and lower concentrations of essential metals compared to women, which may impact their lifespan. LASSO regression and random forest models identified significant metals associated with various diseases.

ENVIRONMENT INTERNATIONAL (2021)

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Article Environmental Sciences

Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort

Celia Rodriguez-Perez et al.

Summary: This study revealed that adipose tissue concentrations of chromium, iron, and copper were associated with the incidence of T2DM over a 16-year follow-up period. Additionally, vanadium and zinc concentrations were positively correlated with pancreatic cell function, while selenium showed an inverse association. These findings suggest that certain trace elements in adipose tissue may play a role in the development of T2DM and have potential implications for identifying individuals at risk.

ENVIRONMENTAL POLLUTION (2021)

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Article Environmental Sciences

Occupational exposure to potentially toxic elements in the foundry industry: an integrated environmental and biological monitoring

Bruna Moreira Freire et al.

Summary: The study found that industrial foundry workers are exposed to multiple potentially toxic elements, with some workers having high concentrations of arsenic and cadmium. The concentration of these elements in different biological samples is significantly influenced by work tasks and employment years. This occupational exposure is associated with both carcinogenic and noncarcinogenic risks.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Circulating antioxidant vitamins and copper in Azorean coronary artery disease patients under preventive medication - A case study

Ana Lima et al.

Summary: This study found that patients with CAD had lower levels of vitamin C and higher levels of plasma copper. Plasma copper concentration may be an independent risk factor in primary prevention of CAD in men.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2021)

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Article Environmental Sciences

Trace Element Analysis in Whole Blood and Plasma for Reference Levels in a Selected Queensland Population, Australia

Tatiana Komarova et al.

Summary: This study aimed to provide blood reference levels of 21 trace elements in Queensland and found significant differences between males and females, as well as variations with age in the levels of certain trace elements. The study contributes to the understanding of trace element levels in blood and highlights the need for further research in this area.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Environmental Sciences

Elemental plasma content and urinary excretion in vineyard farmers occupationally exposed to pesticides in southern Brazil

Renata Sano Lini et al.

Summary: This cross-sectional study in southern Brazil collected data and biological material from vineyard farmers, screening plasma and urine samples for various elemental contents. The farmers showed higher concentrations of certain trace elements in their biological material compared to unexposed populations. The study highlights the association between trace elements and pesticide use patterns, addressing gaps in the literature on trace element content in plasma and urine of workers exposed to pesticides.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Public, Environmental & Occupational Health

Trace element analysis of human seminal plasma: A cautionary tale of preanalytical variation and use of non-traditional matrices in human biomonitoring studies

Aubrey L. Galusha et al.

Summary: The study highlights the analytical challenge of ensuring harmonization of (ultra-)trace element measurements in non-traditional matrices. Various validation methods were used to achieve consistency with standard reference values, and a potential source of contamination was identified. However, lack of consensus still exists for the content of certain elements in seminal plasma.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2021)

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Review Cardiac & Cardiovascular Systems

Iron in Cardiovascular Disease: Challenges and Potentials

Shizhen Li et al.

Summary: Iron plays essential roles in cardiovascular diseases, with iron deficiency having detrimental effects in heart failure and pulmonary arterial hypertension patients. Ferroptosis, an iron-dependent cell death, has been reported in cardiomyopathy, atherosclerotic cardiovascular disease, and myocardial ischemia/reperfusion injury. Iron chelation therapy may be a potential strategy to address iron overload-related disorders in CVD.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Particle and metal exposure in Parisian subway: Relationship between exposure biomarkers in air, exhaled breath condensate, and urine

I. Guseva Canu et al.

Summary: Subway particulate toxicity differs between in vitro and in vivo studies, calling for further research on outcomes from chronic exposures and exposure biomarkers. Monitoring of subway workers revealed varied daily temporal variation patterns in particle and metal exposures in PM, urine, and EBC matrices, highlighting the need for toxicological research to explore factors influencing health effects of low chronic exposures to subway particulates. Further studies should focus on understanding the health impacts of long-term exposure to subway particulates in larger population cohorts.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2021)

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Article Nutrition & Dietetics

The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data

Abdelhamid Kerkadi et al.

Summary: Zn is not strongly correlated with CMR factors and MetS. Cu levels correlate positively with BMI, PR, total cholesterol, and HDL; and negatively with DBP. High plasma Cu significantly decreases the risk of MetS. Furthermore, Zn/Cu ratio correlates positively with waist circumference, SBP, and DBP; and negatively with BMI, PR, and HDL. High Zn/Cu ratio increases the prevalence of low HDL and MetS.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Dietary patterns related to zinc and polyunsaturated fatty acids intake are associated with serum linoleic/dihomo-γ-linolenic ratio in NHANES males and females

Jacqueline Pontes Monteiro et al.

Summary: Identifying dietary patterns that contribute to zinc and fatty acids intake can have an impact on biomarkers related to male and female health, demonstrating significant differences between genders.

SCIENTIFIC REPORTS (2021)

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Article Peripheral Vascular Disease

Circulating Serum Copper Is Associated with Atherosclerotic Cardiovascular Disease, but Not Venous Thromboembolism: A Prospective Cohort Study

Setor K. Kunutsor et al.

Summary: This study aimed to evaluate the potential association between serum copper and VTE risk, finding that high serum copper levels were associated with increased risk of atherosclerotic CVD in middle-aged Finnish men, but not with future VTE risk. Further large-scale prospective studies are needed to confirm or refute these findings in women, other age groups, and other populations.

PULSE (2021)

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Article Genetics & Heredity

Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation

Elizabeth R. Everman et al.

Summary: The release of heavy metals poses a threat to organisms, and resistance to copper toxicity is genetically complex, influenced by allelic and expression variation at multiple loci.

GENETICS (2021)

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Article Nutrition & Dietetics

Changes of trace element status during aging: results of the EPIC-Potsdam cohort study

Julia Baudry et al.

EUROPEAN JOURNAL OF NUTRITION (2020)

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Review Food Science & Technology

Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies

Angelica Kuria et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

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Review Gastroenterology & Hepatology

Recent insights into trace element deficiencies: causes, recognition and correction

Boutaina Zemrani et al.

CURRENT OPINION IN GASTROENTEROLOGY (2020)

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Article Environmental Sciences

Exposure to multiple metals in early pregnancy and gestational diabetes mellitus: A prospective cohort study

Xiaoyi Wang et al.

ENVIRONMENT INTERNATIONAL (2020)

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Article Nutrition & Dietetics

Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?

Marija Knez et al.

NUTRIENTS (2020)

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Article Environmental Sciences

A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures

Alexander P. Keil et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2020)

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Article Nutrition & Dietetics

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

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Biomonitoring of arsenic, cadmium, lead, manganese and mercury in urine and hair of children living near mining and industrial areas

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Higher Selenium Status is Associated with Adverse Blood Lipid Profile in British Adults

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Plasma levels of copper, manganese and selenium in an adult population in southern Spain: Influence of age, obesity and lifestyle factors

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SCIENCE OF THE TOTAL ENVIRONMENT (2010)

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Serum Selenium Concentrations and Diabetes in US Adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004

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Daily dietary intake of iron, copper, zinc and manganese in a Spanish population

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Assessment of iron and zinc intake and related biochemical parameters in an adult Mediterranean population from southern Spain: influence of lifestyle factors

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Biomarkers of copper status: a brief update

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Indicators of zinc status at the population level: a review of the evidence

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CURRENT OPINION IN LIPIDOLOGY (2008)

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Selenium: its role as antioxidant in human health

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How reliable and robust are current biomarkers for copper status?

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Conclusions of the joint WHO/UNICEF/IAEA/lZiNCG Interagency meeting on zinc status indicators

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Article Nutrition & Dietetics

Selenium and coronary heart disease: a meta-analysis

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Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality

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Dietary exposure estimates of 18 elements from the 1st French Total Diet Study

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Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders

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Pro- or anti-oxidant manganese: a suggested mechanism for reconciliation

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Survey of persistent organochlorine contaminants (PCBs, PCDD/Fs, and PAHs), heavy metals (Cu, Cd, Zn, Pb, and Hg), and arsenic in food samples from Huelva (Spain):: Levels and health implications

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Total-diet study: dietary intakes of macro elements and trace elements in Italy

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Increased oxidative stress and hypozincemia in male obesity

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Aluminum, boron, calcium, copper, iron, magnesium, manganese, molybdenum, phosphorus, potassium, sodium, and zinc: Concentrations in common Western foods and estimated daily intakes by infants; toddlers; and male and female adolescents, adults, and seniors in the United States

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JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION (2001)

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Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations:: Ecogenetic studies in a mediterranean Spanish population

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Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population

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