期刊
ANTIOXIDANTS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/antiox11091788
关键词
gasotransmitter; persulfidation; reactive sulfur species; reactive species interactome
资金
- National Institute of Health [RO1HD105301]
- American College of Surgeons Clowe's Memorial Research Fund
- Gerber Foundation
- Riley Children's Foundation
- National Science Foundation [10S2012106]
- Indiana University Department of Surgery
Hydrogen sulfide is the third biological gasotransmitter and has potential therapeutic applications in cardiovascular, inflammatory, infectious, and neuropathological diseases. It directly interacts with reactive oxygen/nitrogen species and is involved in redox signaling. The direct modifications by hydrogen sulfide significantly impact cell structure and various cellular functions.
Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory, infectious and neuropathological diseases have been undertaken. Here we review the possible direct targets of H2S in mammals. H2S directly interacts with reactive oxygen/nitrogen species and is involved in redox signaling. H2S also reacts with hemeproteins and modulates metal-containing complexes. Once being oxidized, H2S can persulfidate proteins by adding -SSH to the amino acid cysteine. These direct modifications by H2S have significant impact on cell structure and many cellular functions, such as tight junctions, autophagy, apoptosis, vesicle trafficking, cell signaling, epigenetics and inflammasomes. Therefore, we conclude that H2S is involved in many important cellular and physiological processes. Compounds that donate H2S to biological systems can be developed as therapeutics for different diseases.
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