4.7 Article

Hesperidin Protects SH-SY5Y Neuronal Cells against High Glucose-Induced Apoptosis via Regulation of MAPK Signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

Jasvinder Singh Bhatti et al.

Summary: Type 2 diabetes is a rapidly rising metabolic disorder characterized by insulin resistance and beta-cell dysfunction. High blood sugar levels lead to the production of reactive oxygen species (ROS) and oxidative stress, which contribute to the development and progression of the disease. Antioxidants can neutralize ROS and maintain bodily homeostasis. However, the efficacy of antioxidant therapies in preventing diabetes is conflicting in clinical evidence.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Article Toxicology

Pendulone induces apoptosis via the ROS-mediated ER-stress pathway in human non-small cell lung cancer cells

Wen-Chien Cheng et al.

Summary: Pendulone induces apoptosis in NSCLC cell lines by inducing ER stress through ROS accumulation and mitochondrial dysfunction.

TOXICOLOGY IN VITRO (2022)

Article Cell Biology

The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

Liling Deng et al.

Summary: Foot ulcers in diabetic patients are often caused by various factors leading to slow wound healing, in which oxidative stress and antioxidants play important roles. By reducing oxidative stress levels, oxidative damage can be minimized to facilitate wound healing.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Cell Biology

Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Zhipeng Su et al.

Summary: The study demonstrated that Ciclopirox (CPX) exhibits strong anti-tumorigenic activity on glioblastoma multiforme (GBM) by inhibiting cellular migration and invasion, reducing the expression of Snail and N-Cadherin. Additionally, the combination of CPX and Bortezomib (BTZ) can promote apoptosis in GBM cells through reactive oxygen species (ROS)-mediated signaling pathways.

CELL DEATH & DISEASE (2021)

Article Neurosciences

Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells

Mayuko Sugimoto et al.

Summary: Formononetin protects against H2O2-induced neuroblastoma cell death by reducing ROS levels and enhancing antioxidant gene expression through the activation of the PI3K/Akt-Nrf2 signaling pathway. Additionally, formononetin suppresses apoptosis by inhibiting MAPK phosphorylation in SH-SY5Y cells, suggesting its potential as a therapeutic agent for neurodegenerative diseases.

NEUROTOXICOLOGY (2021)

Review Biochemistry & Molecular Biology

Mitostasis, Calcium and Free Radicals in Health, Aging and Neurodegeneration

Juan A. Godoy et al.

Summary: Mitochondria play critical roles in neurons by regulating neurotransmission and synaptic plasticity through ATP supply, calcium homeostasis, redox balance control, and apoptosis. Their functional integrity is mainly maintained by mitostasis, involving processes like mitochondrial transport, anchoring, fusion, and fission, regulated by various signaling pathways. The communication between mitochondria and the endoplasmic reticulum (ER) via mitochondria-associated membranes (MAMs) is crucial for Ca2+ buffering. Alterations in mitochondrial activity can lead to increased production of reactive oxygen species, disturbance in physiological metabolism, and mitochondrial dysfunction resulting in cell death through apoptosis.

BIOMOLECULES (2021)

Review Clinical Neurology

Challenges of neuropathic pain: focus on diabetic neuropathy

Daniela C. Rosenberger et al.

JOURNAL OF NEURAL TRANSMISSION (2020)

Article Orthopedics

Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer

David G. Armstrong et al.

JOURNAL OF FOOT AND ANKLE RESEARCH (2020)

Review Physiology

Glucose transporters in brain in health and disease

Hermann Koepsell

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

Marziyeh Hajialyani et al.

MOLECULES (2019)

Review Biochemistry & Molecular Biology

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Anju Singh et al.

MOLECULES (2019)

Article Endocrinology & Metabolism

Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice

Yalan Cheng et al.

DIABETES (2019)

Article Biochemistry & Molecular Biology

Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5

Ao Xuan Zhen et al.

BIOMOLECULES & THERAPEUTICS (2019)

Article Biochemistry & Molecular Biology

7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress

Suk Ju Cho et al.

BIOMOLECULES & THERAPEUTICS (2019)

Article Chemistry, Medicinal

Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging

Yu Jae Hyun et al.

MARINE DRUGS (2019)

Article Endocrinology & Metabolism

Association of diabetic foot ulcers with chronic vascular diabetic complications in patients with type 2 diabetes

Magdy H. Megallaa et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2019)

Review Pharmacology & Pharmacy

Role of Oxidative Stress in Diabetic Retinopathy and the Beneficial Effects of Flavonoids

Mohammad Shamsul Ola et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Review Neurosciences

The SH-SY5Y cell line in Parkinson's disease research: a systematic review

Helena Xicoy et al.

MOLECULAR NEURODEGENERATION (2017)

Review Biochemistry & Molecular Biology

ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key Players

Entaz Bahar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer's Disease in Wistar Rats

Arokiasamy Justin Thenmozhi et al.

NEUROCHEMICAL RESEARCH (2015)

Review Biochemistry & Molecular Biology

ER Stress in Diabetic Peripheral Neuropathy: A New Therapeutic Target

Phillipe D. O'Brien et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Biochemistry & Molecular Biology

The Polyphenol Chlorogenic Acid Attenuates UVB-mediated Oxidative Stress in Human HaCaT Keratinocytes

Ji Won Cha et al.

BIOMOLECULES & THERAPEUTICS (2014)

Review Neurosciences

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

Elena Radi et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Review Neurosciences

DNA Damage and Its Links to Neurodegeneration

Ram Madabhushi et al.

NEURON (2014)

Article Clinical Neurology

Mitochondria, oxidative stress and neurodegeneration

Antonio Federico et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)

Article Biochemistry & Molecular Biology

Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats

Xiupu Shi et al.

MOLECULES (2012)

Review Neurosciences

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

Vittorio Calabrese et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Review Biochemistry & Molecular Biology

Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species

Cesare Mancuso et al.

REDOX REPORT (2006)

Article Biotechnology & Applied Microbiology

Phenolics as potential antioxidant therapeutic agents: Mechanism and actions

MA Soobrattee et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)

Article Endocrinology & Metabolism

Sensory neurons with activated caspase-3 survive long-term experimental diabetes

C Cheng et al.

DIABETES (2003)