期刊
JOURNAL OF MEDICAL VIROLOGY
卷 89, 期 3, 页码 508-517出版社
WILEY-BLACKWELL
DOI: 10.1002/jmv.24634
关键词
Epstein-Barr virus; gastrointestinal analysis; apoptosis/cell death; tumor suppressor genes
类别
资金
- Ministry of Education
- Culture
- Science and Technology of Japan [26460938]
- Grants-in-Aid for Scientific Research [26460938] Funding Source: KAKEN
The present study investigated the effect of a DNA demethylating agent, decitabine, against Epstein-Barr virus-associated gastric cancer (EBVaGC). Decitabine inhibited cell growth and induced G2/M arrest and apoptosis in EBVaGC cell lines. The expression of E-cadherin was up-regulated and cell motility was significantly inhibited in the cells treated with decitabine. The promoter regions of p73 and RUNX3 were demethylated, and their expression was upregulated by decitabine. They enhanced the transcription of p21, which induced G2/M arrest and apoptosis through down-regulation of c-Myc. Decitabine also induced the expression of BZLF1 in SNU719. Induction of EBV lytic infection was an alternative way to cause apoptosis of the host cells. This study is the first report to reveal the effectiveness of a demethylating agent in inhibiting tumor cell proliferation and up-regulation of E-cadherin in EBVaGC. (C) 2016 Wiley Periodicals, Inc.
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