The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

Review Biochemistry & Molecular Biology

Epigenetics in the pathogenesis of diabetic nephropathy

Xue Li et al.

Summary: This review discusses the important role of epigenetics in diabetic nephropathy, which affects the progression of the disease through various mechanisms and ultimately leads to a poor prognosis.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2022)

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Article Physiology

The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse

Badr Khbouz et al.

Summary: The loss of DUSP3 function is associated with increased kidney resistance to ischemia/reperfusion, potentially due to reduced inflammation and improved perfusion.

ACTA PHYSIOLOGICA (2022)

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Article Pharmacology & Pharmacy

Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by Naringenin

Mohammad Fareed Khan et al.

Summary: This study reveals the critical role of the TRB3-FoxO1 signaling pathway and the novel role of Naringenin in regulating ER stress during hyperglycemic renal toxicity. Naringenin reduces TRB3 expression and alleviates FoxO1-mediated apoptosis. Additionally, Naringenin reduces insulin resistance, apoptosis, and glycogen accumulation, and enhances glucose tolerance. These findings suggest that Naringenin may be a novel approach for managing hyperglycemic renal toxicity by modulating ER stress.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model

Azza Mohammed Hafez El Medany et al.

Summary: The study compared the effects of dapagliflozin, liraglutide, and atorvastatin alone or in combination on lipids, inflammatory markers, and vascular impact in T2D rats. Liraglutide and the combination groups significantly improved all studied parameters, while dapagliflozin had positive effects on some parameters but potentially negative effects on others.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2022)

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Article Medicine, Research & Experimental

A ketogenic diet attenuates acute and chronic ischemic kidney injury and reduces markers of oxidative stress and inflammation

Pedro Rojas-Morales et al.

Summary: This study found that short-term ketogenic diet can increase tolerance to experimental kidney ischemia, reduce kidney injury and inflammation, and enhance antioxidant defenses. This finding opens up possibilities for future therapeutic strategies.

LIFE SCIENCES (2022)

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Article Chemistry, Medicinal

Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF-kappa B, TNF-alpha and COX-2 proteins in rats

Brahmjot Singh et al.

Summary: Vanillic acid has antidiabetic and renoprotective effects in diabetic nephropathic rats, which may be attributed to its various pharmacological activities, including antioxidant and anti-inflammatory effects.

PHYTOTHERAPY RESEARCH (2022)

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Article Endocrinology & Metabolism

Amelioration of diabetes and its complications by Manilkara zapota (L) P. Royen fruit peel extract and its fractions in alloxan and STZ-NA induced diabetes in Wistar rats

Pravin P. Karle et al.

Summary: The study evaluated the effects of Manilkara zapota fruit peel extract and its fractions in ameliorating diabetes and its complications. It found that the extract and its fractions improved glycemic control and associated biochemical alterations, leading to a reduction in the symptoms of diabetes and its complications.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2022)

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Article Medicine, Research & Experimental

Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy

George J. Dugbartey et al.

Summary: The study found that ALA supplementation can prevent the early development and progression of DN, exerting anti-hyperglycemic, antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic effects.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Pathology

Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats

Hayarpi Javrushyan et al.

Summary: This study suggests that L-norvaline and L-arginine have antihyperglycemic effects and can serve as alternative therapeutic tools for individuals with hyperglycemia and prediabetes.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2022)

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Article Biochemistry & Molecular Biology

Renoprotective potential of myo-inositol on diabetic kidney disease: Focus on the role of the PINK1/Parkin pathway and mitophagy receptors

Bhoomika Sherkhane et al.

Summary: This study aimed to evaluate the protective role of myo-inositol (MI) against diabetic nephropathy (DN) and found that MI supplementation improved renal function and ameliorated albuminuria. In addition, the study revealed that MI treatment reversed poor mitophagy in renal cells and upregulated mitophagy proteins. Furthermore, MI enhanced mitochondrial biogenesis in renal tissue through the regulation of Nrf2/SIRT1/PGC-1 alpha axis.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

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Review Biochemistry & Molecular Biology

The effects of exercise on kidney injury: the role of SIRT1

Nazanin Sabet et al.

Summary: Exercise has a renoprotective effect on kidney injury patients by increasing the expression and activity of SIRT1. However, further research is needed to determine the role of SIRT1 in different types and severities of kidney injury following exercise.

MOLECULAR BIOLOGY REPORTS (2022)

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Review Chemistry, Medicinal

Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy

Hongjie Wang et al.

Summary: A growing body of scientific evidence shows that protein homeostasis is linked to chronic diabetic nephropathy (DN). Insulin signaling in podocytes plays a crucial role in maintaining the unfolded protein response (UPR), and defective insulin signaling can lead to maladaptive UPR and DN. Anticoagulant serine protease-activated protein C (aPC) also has a cytoprotective effect in DN. Understanding the molecular mechanisms of adaptive and detrimental responses in renal cells can help develop new therapeutic strategies for DN.

PHARMACEUTICALS (2022)

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Article Endocrinology & Metabolism

1,8 cineole protects type 2 diabetic rats against diabetic nephropathy via inducing the activity of glyoxalase-I and lowering the level of transforming growth factor-1β

Sina Mahdavifard et al.

Summary: The study showed that 1,8 cineole had a positive effect on renal function and histopathology in type 2 diabetic rats, reducing indicators of diabetic nephropathy and alleviating the levels of glycation, oxidative stress, and pro-inflammatory markers. Additionally, it had beneficial effects on glucose and lipid metabolism.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2022)

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Article

Anti-Oxidative Therapy in Diabetic Nephropathy

Luis F. Hernandez et al.

Frontiers in Bioscience - Scholar (2022)

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Article Cell Biology

Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury

Jia-Long Tang et al.

Aging-US (2022)

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Article Nutrition & Dietetics

The Effect of Curcumin on Renal Ischemia/Reperfusion Injury in Diabetic Rats

Douglas Ikedo Machado et al.

Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.

NUTRIENTS (2022)

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Review Biochemical Research Methods

Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation

Haryana Y. Thomas et al.

Summary: Diabetic nephropathy, caused by diabetes, is a kidney complication that leads to the highest mortality rate in diabetic patients. Although the main causes of diabetic nephropathy have been identified, the mechanisms by which they affect cellular and tissue function are not fully understood. Mesangial expansion, characterized by abnormal proliferation of cells and excessive production of matrix proteins, is a major damage in diabetic nephropathy and its impact on kidney function is not well defined.

JOURNAL OF BIOLOGICAL ENGINEERING (2022)

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Article Nutrition & Dietetics

Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice

Meijuan Bai et al.

Summary: Short-term caloric restriction (CR) promotes erythropoiesis and ameliorates phenylhydrazine-induced acute anemia.

FRONTIERS IN NUTRITION (2022)

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Review Biology

Up-Date on Diabetic Nephropathy

Maria Chiara Pelle et al.

Summary: Diabetes is a leading cause of kidney disease, specifically diabetic kidney disease (DKD) which is associated with increased cardiovascular risk. Chronic hyperglycemia and high blood pressure are risk factors for DKD, but blockade of the renin-angiotensin-aldosterone system can improve glomerular function and cardiovascular risk. New antidiabetic drugs have shown promise in delaying kidney disease progression and improving cardiovascular outcomes.

LIFE-BASEL (2022)

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Article Pharmacology & Pharmacy

Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart - The role of cardiac hydrogen sulfide-synthesizing enzymes

George J. Dugbartey et al.

Summary: Alpha-lipoic acid (ALA) is a licensed drug for the treatment of diabetic neuropathy and diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus (T2DM). This study shows that ALA preserves myocardial integrity in T2DM by upregulating cardiac hydrogen sulfide (H2S)-synthesizing enzymes and increasing plasma H2S level.

BIOCHEMICAL PHARMACOLOGY (2022)

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Article Medicine, Research & Experimental

Activation of renal CSE/H2S pathway by alpha-lipoic acid protects against histological and functional changes in the diabetic kidney

George J. Dugbartey et al.

Summary: The study reveals that alpha-lipoic acid (ALA) protects against the progression of diabetic kidney disease (DKD) by activating renal cystathionine gamma-lyase/hydrogen sulfide (CSE/H2S) system in type 2 diabetes mellitus (T2DM).

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Physiology

Kidney-targeted irradiation triggers renal ischemic preconditioning in mice

Badr Khbouz et al.

Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2022)

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Article Physiology

Regulation of kidney mitochondrial function by caloric restriction

Julian D. C. Serna et al.

Summary: Caloric restriction (CR) prevents obesity and increases resilience against pathological stimuli, but it may have unexpected deleterious effects in the kidneys, including increased mitochondrial reactive oxygen production and permeability transition.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2022)

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Article Medicine, General & Internal

Dapagliflozin Ameliorates Lipopolysaccharide Related Acute Kidney Injury in Mice with Streptozotocin-induced Diabetes Mellitus

Po-Jui Chi et al.

Summary: The study found that the SGLT2 inhibitor dapagliflozin can alleviate LPS-induced endotoxic shock with AKI and reduce inflammatory cytokines in diabetic mice. This effect may be mediated by activating the AMPK pathway.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2022)

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Review Urology & Nephrology

Role of Mitochondrial Therapy for Ischemic-Reperfusion Injury and Acute Kidney Injury

Navjot Pabla et al.

Summary: AKI, a common clinical disorder, involves multiple cellular mechanisms with mitochondrial injury at its core. Treatment strategies targeting mitochondrial health have shown promise in mitigating AKI.

NEPHRON (2022)

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Review Urology & Nephrology

Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury

Felix C. Koehler et al.

Summary: Caloric restriction (CR) has shown to be highly effective in protecting organs in rodent models of acute kidney injury (AKI), but limited understanding of the mechanisms, risk of malnourishment, and feasibility issues have hindered its translation to patient settings. This mini-review highlights potential key targets for renal protection in AKI by focusing on the current mechanistic concepts of CR-mediated stress-resistance.

NEPHRON (2022)

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Article Multidisciplinary Sciences

Alkaloidal extract from Zanthoxylum zanthoxyloides stimulates insulin secretion in normoglycemic and nicotinamide/streptozotocin-induced diabetic rats

Isaac Kyei-Barffour et al.

Summary: The alkaloidal extract derived from Zanthoxylum zanthoxyloides showed antidiabetic and insulin secretory effects in normoglycemic and experimental diabetic rats, with potential for diabetes management. The extract improved glucose kinetics, restored islet population, and insulin levels, and stimulated insulin secretion, indicating its potential as a treatment for diabetes.

HELIYON (2021)

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Article Biochemistry & Molecular Biology

Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis

Meijuan Bai et al.

Summary: Intermittent caloric restriction through a modified fasting-mimicking diet was effective in treating autoimmune encephalomyelitis (EAE) by reducing disease severity, immune cell infiltration, and demyelination, while promoting tissue recovery.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Review Medicine, General & Internal

Ketone bodies: from enemy to friend and guardian angel

Hubert Kolb et al.

Summary: During times of starvation or low carbohydrate intake, circulating insulin levels decrease, leading to fat breakdown serving as the primary energy source, with ketone bodies acting as ancillary fuel. Ketone bodies not only serve as fuel but also promote resistance to oxidative and inflammatory stress, while decreasing insulin-dependent energy expenditure.

BMC MEDICINE (2021)

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Article Transplantation

Targeted deletion of nicotinamide adenine dinucleotide phosphate oxidase 4 from proximal tubules is dispensable for diabetic kidney disease development

Vicki Thallas-Bonke et al.

Summary: Genetic deletion of Nox4 from the proximal tubules does not influence the development of DKD, indicating that the localization of Nox4 within this kidney compartment is dispensable for the pathogenesis of chronic kidney disease in the setting of diabetes.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Article Biochemistry & Molecular Biology

L-NAME Administration Enhances Diabetic Kidney Disease Development in an STZ/NAD Rat Model

Raphaelle Corremans et al.

Summary: The study successfully developed a rat model of DKD by combining STZ/NAD and oral L-NAME, inducing diabetes, hypertension, and characteristic features of DKD, providing a new animal model for DKD research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Sodium hydrosulfide has no additive effects on nitrite-inhibited renal gluconeogenesis in type 2 diabetic rats

Sajad Jeddi et al.

Summary: Nitrite can reduce mRNA expression of renal gluconeogenic genes in T2D rats, and co-administration with NaSH further decreases FoxO1 expression level. In addition, co-administration of nitrite and NaSH can also decrease serum urea and creatinine levels in T2D rats.

LIFE SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Berberine Improves the Protective Effects of Metformin on Diabetic Nephropathy in db/db Mice through Trib1-dependent Inhibiting Inflammation

Bin Zhang et al.

Summary: The study found that treatment of diabetic db/db mice with Met, BBR, or a combination of both could effectively lower blood glucose levels and improve insulin resistance. Combination therapy also showed enhanced effects on lipids metabolism and attenuated the progression of diabetic nephropathy.

PHARMACEUTICAL RESEARCH (2021)

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Article Chemistry, Medicinal

Role of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy

Arslan Hussain Lodhi et al.

Summary: This study demonstrated the antioxidant potential of H2S and captopril in the treatment of streptozotocin-induced diabetic nephropathy. The results showed that treatment with these compounds improved renal hemodynamics and oxidative stress markers, with a more pronounced effect observed in combined treatment groups.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Immunology

Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

Pan Liu et al.

Summary: Research has shown that the pyroptosis-related inflammasome pathway plays a crucial role in the development of DKD, and inhibiting its activation can improve the pathological changes associated with the disease. However, current studies on this topic are still relatively superficial and further exploration is needed for a better understanding.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Schiff Bases of Pioglitazone Provide Better Antidiabetic and Potent Antioxidant Effect in a Streptozotocin-Nicotinamide-Induced Diabetic Rodent Model

Hafiza Rabia Afzal et al.

Summary: This study synthesized four new Schiff bases of pioglitazone, with P3 showing superior antioxidant effects and antidiabetic properties, leading to significant and better results in a rodent model. P3 demonstrated significant impacts on enzymatic and nonenzymatic antioxidants and exhibited potent inhibitory effects in in vitro experiments.

ACS OMEGA (2021)

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Review Biochemistry & Molecular Biology

Diabetic Nephropathy - a Review of Risk Factors, Progression, Mechanism, and Dietary Management

Vijayakumar Natesan et al.

Summary: This review discusses the health problems caused by Type 2 diabetes mellitus (T2DM), particularly diabetic nephropathy (DN), and explores the pathogenesis, risk factors, progression, and effects of glycemic levels on DN. It also looks into novel diagnostic and therapeutic approaches for DN, such as gene therapy and stem cell treatments.

BIOMOLECULES & THERAPEUTICS (2021)

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Review Biochemistry & Molecular Biology

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

Liang-Jun Yan et al.

Summary: Cadmium, a nonessential metal heavily polluting the environment, can cause chronic damage to the kidneys, mainly accumulating in and damaging the proximal tubule of nephrons. Oxidative damage serves as a unifying mechanism for cadmium-induced renal toxicity, with antioxidants potentially ameliorating the injury.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats

Itaru Monno et al.

Summary: This study found that 8 weeks of treadmill exercise training significantly reduced kidney injuries in type 2 diabetic obese rats, suppressing tubulointerstitial fibrosis, inflammation, and oxidative stress, promoting autophagy, and restoring mitochondrial abnormalities.

ANTIOXIDANTS (2021)

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Article Food Science & Technology

Bitter Gourd Honey Ameliorates Hepatic and Renal Diabetic Complications on Type 2 Diabetes Rat Models by Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

Chandra Sekhar Arigela et al.

Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.

FOODS (2021)

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Review Physiology

Epigenetics and Inflammation in Diabetic Nephropathy

Bao-Yi Shao et al.

Summary: Diabetic nephropathy (DN) is a disease that leads to high morbidity and disability, with inflammation playing a critical role in its pathogenesis. Epigenetic modifications regulate gene expression without altering the DNA sequence, and recent studies have revealed the mechanisms behind this regulation in DN's inflammation.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Endocrinology & Metabolism

SIRT1: Mechanism and Protective Effect in Diabetic Nephropathy

Jing Ji et al.

Summary: SIRT1 plays a protective role in the pathogenesis of diabetic nephropathy by attenuating proteinuria and kidney injury through deacetylation of transcription factors involved in the disease process.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2021)

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Review Biochemistry & Molecular Biology

NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

Liang-Jun Yan

Summary: Diabetic kidney disease (DKD) is a common and severe complication of diabetes, mainly driven by NADH/NAD(+) redox imbalance and mitochondrial dysfunction. The review discusses strategies to counteract DKD, including the use of mitochondria-targeted antioxidants and caloric restriction.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

DUSP1 overexpression attenuates renal tubular mitochondrial dysfunction by restoring Parkin-mediated mitophagy in diabetic nephropathy

Chang Lu et al.

Summary: The study showed that DUSP1 partially restored autophagic flux, improved mitochondrial function, and reduced reactive oxygen species generation and cell apoptosis under high-glucose conditions. By restoring parkin-mediated mitophagy, DUSP1 may be considered a potential therapeutic strategy for treating DN.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Medicine, General & Internal

Diabetes and the kidney

Tahseen A. Chowdhury et al.

Summary: Diabetes is the most common cause of end-stage kidney disease, with sodium-glucose transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists showing beneficial effects in treatment. Early consideration of these drugs is recommended for DKD patients.

CLINICAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Acetate ameliorates nephrotoxicity in streptozotocin-nicotinamide-induced diabetic rats: Involvement of xanthine oxidase activity

Kehinde S. Olaniyi et al.

Summary: The study demonstrates that acetate alleviates diabetes-induced nephrotoxicity, possibly through suppression of XO and its associated pro-inflammatory mediators. This suggests that SCFAs, particularly acetate, could be a promising dietary-derived therapeutic agent for the prevention and management of diabetes-associated renal disturbances.

CYTOKINE (2021)

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Article Biochemistry & Molecular Biology

Exercise training ameliorates early diabetic kidney injury by regulating the H2S/SIRT1/p53 pathway

Lu Yang et al.

Summary: Exercise training can protect the kidneys from diabetic nephropathy by regulating endogenous hydrogen sulfide production, reducing renal injury and apoptosis, increasing SIRT1 expression, inhibiting the p53-mediated apoptotic pathway, and improving diabetic nephropathy.

FASEB JOURNAL (2021)

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Article Endocrinology & Metabolism

Overexpression of lipoic acid synthase gene alleviates diabetic nephropathy of Leprdb/db mice

Yingzheng Zhao et al.

Summary: The study found that mice with increased endogenous antioxidant capacity were able to alleviate major pathological alterations in the early stage of diabetic nephropathy, with significantly enhanced antioxidant defense. This antioxidant animal model not only helps to elucidate the underlying mechanisms of DN, but also provides insight into a new therapeutic strategy for clinical applications.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

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Review Biochemistry & Molecular Biology

Folic acid-induced animal model of kidney disease

Liang-Jun Yan

Summary: The kidneys are vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD), with animal models being crucial for studying the pathological mechanisms of kidney disease. This article reviews a widely used animal model of kidney disease induced by folic acid (FA), discussing the major mechanisms of FA-induced kidney injury and its application in testing therapeutic approaches.

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Synergistic effect of micronutrients and metformin in alleviating diabetic nephropathy and cardiovascular Dysfunctioning in diabetic rat

Aaishwarya Deshmukh et al.

Summary: The study demonstrates a synergistic effect of metformin and micronutrients against diabetic heart and kidney, suggesting that micronutrients may serve as an effective add-on therapy for DN and CVD.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

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Review Biochemistry & Molecular Biology

Ketone bodies, stress response, and redox homeostasis

Pedro Rojas-Morales et al.

REDOX BIOLOGY (2020)

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Article Biology

Evaluation of antidiabetic activity of Pleurotus pulmonarius against streptozotocin-nicotinamide induced diabetic wistar albino rats

P. Balaji et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Review Biochemistry & Molecular Biology

beta-hydroxybutyrate and its metabolic effects on age-associated pathology

Han Young-Min et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Review Urology & Nephrology

The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?

Anne C. Hesp et al.

KIDNEY INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid

Omar Emiliano Aparicio-Trejo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Plant Sciences

Glucose lowering and pancreato-protective effects of Abrus Precatorius (L.) leaf extract in normoglycemic and STZ/Nicotinamide - Induced diabetic rats

Alex Boye et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Zhuo Li et al.

CLINICAL SCIENCE (2020)

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Article Cell Biology

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Alaa M. Ali et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Plant Sciences

Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and in-silico experiments

Mabozou Kpemissi et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Nutrition & Dietetics

Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study

Wen-Chun Yu et al.

NUTRIENTS (2020)

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Review Pharmacology & Pharmacy

Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets

Carlamaria Zoja et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Integrative & Complementary Medicine

Nephroprotective effect of Curculigo orchiodies in streptozotocin-nicotinamide induced diabetic nephropathy in wistar rats

Krishan Singla et al.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2020)

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Article Health Care Sciences & Services

Efficacy and safety of Bailing capsules in the treatment of type 2 diabetic nephropathy: a meta-analysis

Xiaohua Sheng et al.

ANNALS OF PALLIATIVE MEDICINE (2020)

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Article Immunology

Renoprotective effects of Tilianin in diabetic rats through modulation of oxidative stress via Nrf2-Keapl pathway and inflammation via TLR4/MAPK/NF-κB pathways

Ruibin Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Standardization of type 1 and type 2 diabetic nephropathy models in rats: Assessment and characterization of metabolic features and renal injury

Aakruti A. Kaikini et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2020)

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Review Medicine, General & Internal

Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases

Hee-Seong Jang et al.

FRONTIERS IN MEDICINE (2020)

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Article Pharmacology & Pharmacy

Antidiabetic effect of Drymaria cordata leaf against streptozotocin-nicotinamide-induced diabetic albino rats

Susmita Patra et al.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Fruiting Bodies of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes) Alleviate Diabetes-Associated Oxidative Stress

Wen-Tzu Wu et al.

INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS (2020)

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Article Nutrition & Dietetics

Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic rats

V. V. Sathibabu Uddandrao et al.

EUROPEAN JOURNAL OF NUTRITION (2019)

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Article Biochemistry & Molecular Biology

Rhinacanthins-rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic nephropathy

Ling-Ling Zhao et al.

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