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Pancreatic Cancer Research beyond DNA Mutations

BIOMOLECULES (2022)

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Article Oncology

Target c-Myc to treat pancreatic cancer

Moein Ala

Summary: C-Myc overexpression in pancreatic cancer is associated with aggressive behavior of cancer cells and can regulate various cellular processes. Recent studies have shown that C-Myc can be targeted directly or indirectly, offering potential therapeutic strategies for pancreatic cancer.

CANCER BIOLOGY & THERAPY (2022)

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Review Oncology

Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets

Yu Takeda et al.

Summary: This study summarizes the recent research progress on the cancer metabolism mechanisms involved in maintaining genomic stability. The protein deacetylases, sirtuins, are found to be crucial in controlling genomic stability. Additionally, a new type of cell death called ferroptosis determines the survival of clones and has different effects on surrounding cells, which may have implications for cancer treatment.

CANCER SCIENCE (2022)

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Article Oncology

The Role of SMAD4 Inactivation in Epithelial-Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link?

Marie-Lucie Racu et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) has a low survival rate and its incidence is increasing over time. Understanding the molecular mechanisms behind metastasis and chemoresistance in PDAC is crucial, as these are the main causes of death in patients. SMAD4 is deactivated in half of PDAC cases and its loss is associated with worse overall survival and metastasis. SMAD4 is a key transducer in the TGF-beta pathway, which plays a role in epithelial-mesenchymal transition (EMT). EMT is a biological process where epithelial cells lose their characteristics and acquire a more mesenchymal phenotype, leading to increased motility. Recent studies suggest that cells may undergo intermediate states during EMT, known as epithelial-mesenchymal plasticity (EMP), which exhibit enhanced aggressiveness and more efficient metastasis. This review aims to summarize and analyze current knowledge on SMAD4 loss in PDAC patients and investigate its potential role in EMP, in order to better understand its function in PDAC carcinogenesis.

CANCERS (2022)

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Article Gastroenterology & Hepatology

Metagenomic Identification of Microbial Signatures Predicting Pancreatic Cancer From a Multinational Study

Naoyoshi Nagata et al.

Summary: This study identified gut and oral metagenomic signatures that accurately predict pancreatic ductal carcinoma (PDAC) and validated their effectiveness in independent cohorts. Patients with certain microbial species in the gut and oral microbiomes were found to have higher risk of PDAC-related mortality. These findings provide valuable information for the diagnosis and prognosis of PDAC.

GASTROENTEROLOGY (2022)

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Article Oncology

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Leticia Colyn et al.

Summary: By performing proteomic and metabolomic analyses, we identified new pro-tumorigenic mechanisms in intrahepatic cholangiocarcinoma (iCCA), including activation of EGFR signaling or KRAS mutation driving IL6 expression in tumor cells, as well as reprogramming of glucose metabolism and activation of the serine-glycine pathway. These findings provide potential therapeutic targets for iCCA.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Multidisciplinary Sciences

ATP13A3 facilitates polyamine transport in human pancreatic cancer cells

Vandana Sekhar et al.

Summary: The study aims to enhance the understanding of the molecular mechanisms behind mammalian polyamine transport. It identifies ATP13A3 as a polyamine transporter and investigates its role in highly proliferating pancreatic cancer cells. The research establishes the critical role of ATP13A3 in polyamine transport and highlights its potential significance in supporting tumor growth.

SCIENTIFIC REPORTS (2022)

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Review Immunology

Understanding Tricky Cellular and Molecular Interactions in Pancreatic Tumor Microenvironment: New Food for Thought

Antonio Agostini et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, but has a poor prognosis. The tumor microenvironment is an important target for treatment, but further research is needed on cellular interactions within it. The limited efficacy of current treatments is due to the fibrotic tumor microenvironment and immune changes. Combinatorial therapies may be more effective at overcoming drug resistance and killing tumor cells.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool

Heidelinde Sammallahti et al.

Summary: Pancreatic cancer is a aggressive malignancy with poor prognosis. Early diagnosis through non-invasive screening methods is crucial for improving patient survival. This article explores the oncogenomic changes in pancreatic cancer tissue and discusses the potential of using stool as a source for screening these changes. The findings of genomic alterations in stool and the role of altered gut microbiota in pancreatic cancer are also reviewed.

BIOMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Salivary Metabolomics for Oral Squamous Cell Carcinoma Diagnosis: A Systematic Review

Kacper Nijakowski et al.

Summary: Salivary metabolites are reliable for the diagnosis of oral squamous cell carcinoma and can differentiate between different oral diseases. Studies indicate that saliva contains many potential metabolites that could serve as biomarkers. Further research is needed to confirm these findings.

METABOLITES (2022)

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Article Medicine, General & Internal

Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids

Brian C. DeFelice et al.

Summary: This study found significant differences in the concentration of polyamine metabolites in the urine of head and neck cancer patients compared to healthy controls, with only one polyamine metabolite detected at elevated levels in the saliva of patients. These findings suggest that assessing polyamine-based metabolite biomarkers in saliva and urine may have potential as a diagnostic tool for head and neck cancer, but further research is necessary.

DIAGNOSTICS (2022)

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Review Biochemistry & Molecular Biology

EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases

Yasuko Arao et al.

Summary: MicroRNAs (miRNAs) synthesized through a canonical pathway play important roles in human diseases. IsomiRs, variations in noncoding miRNAs, are generated through a non-canonical pathway. EpisomiRs, miRNAs with different modifications, are expanding the isomiR family. IsomiRs reflect cell-specific biological function and studying episomiRs and isomiRs can contribute to optimizing diagnosis and therapeutic technology for precision medicine.

BIOMEDICINES (2022)

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Article Oncology

Salivary metabolomics with machine learning for colorectal cancer detection

Hiroshi Kuwabara et al.

Summary: This study successfully differentiated patients with CRC from those with AD and healthy controls using salivary biomarkers combined with machine learning techniques, demonstrating high accuracy and versatility in detecting CRC.

CANCER SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

Jashodeep Datta et al.

Summary: Co-occurrent KRAS and TP53 mutations are common in patients with pancreatic ductal adenocarcinoma (PDAC) and are associated with worse survival. These mutations lead to innate immune enrichment and CD8(+) T-cell exclusion, as well as affecting transcriptomes and cell migration in the tumor microenvironment. These molecular characteristics can predict chemoresistance and overall survival in patients with metastatic PDAC.

ONCOGENE (2022)

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Article Multidisciplinary Sciences

N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma

Shotaro Tatekawa et al.

Summary: In pancreatic cancer, METTL3 regulates the methylation of PLK1 gene, which affects tumor development and patient prognosis. IGF2BP2 binds to the methylated site of PLK1 RNA and regulates its expression. Demethylation of this site activates mitotic catastrophe and increases radiosensitivity in pancreatic cancer cells.

SCIENTIFIC REPORTS (2022)

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Review Oncology

Emerging Role of CREB in Epithelial to Mesenchymal Plasticity of Pancreatic Cancer

Siddharth Mehra et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid malignancy with high metastasis and therapeutic resistance. Mutational events in oncogenic KRAS and tumor suppressor gene TP53 contribute to PDAC aggressiveness by driving epithelial to mesenchymal plasticity (EMP). Activation of CREB, mediated by oncogenic KRAS, plays a critical role in promoting PDAC aggressiveness and targeting CREB has shown therapeutic potential in mouse models.

FRONTIERS IN ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma

Ryota Chijimatsu et al.

Summary: In this study, a single-cell atlas of pancreatic ductal adenocarcinoma (PDAC) was constructed using six datasets, providing a reference dataset for PDAC and demonstrating its utility in research on the microenvironment and intra-tumor heterogeneity. The analysis revealed cellular heterogeneity in PDAC, with high levels of tumor cells and fibroblasts indicating poor prognosis. Refined tumor subtypes were identified, showing specific regulatory networks and interactions with fibroblast subtypes through different signaling pathways.

ISCIENCE (2022)

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Review Pharmacology & Pharmacy

Diversity of the reaction mechanisms of SAM-dependent enzymes

Qiu Sun et al.

Summary: This article mainly describes the importance of non-methylation reactions of SAM-dependent enzymes in biosynthesis, compares the structural and mechanistic similarities and distinctions between SAM-dependent MTases and non-methylating SAM-dependent enzymes, summarizes the reactions catalyzed by these enzymes, and discusses the structural conservation and catalytical diversity of class I-like non-methylating SAM-dependent enzymes. It also proposes a possibility in enzyme evolution and suggests future perspectives for enzyme-mediated chemistry and biotechnology for the development of new methods for drug synthesis.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Oncology

Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids

Vivien Koh et al.

Summary: The study shows that PD-L1 expression in gastric cancer is mediated by Hh and mTOR signaling pathways. Patient-derived organoid/immune cell co-cultures can be used to study immunosuppressive MDSC function. DSP analysis reveals infiltration of immunosuppressive MDSCs in gastric cancer tissues.

CANCER LETTERS (2021)

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Article Chemistry, Analytical

Volatile organic compounds (VOCs) for the non-invasive detection of pancreatic cancer from urine

Emma Daulton et al.

Summary: The study found that using GC-IMS and GC-TOF-MS techniques to analyze volatile organic compounds in patients' urine can effectively differentiate PDAC from healthy controls, but struggles in distinguishing CP from PDAC. Important biomarkers identified include 2,6-dimethyl-octane, nonanal, 4-ethyl-1,2-dimethyl-benzene, and 2-pentanone.

TALANTA (2021)

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Article Biochemistry & Molecular Biology

Tumor-Specific miRNA Signatures in Combination with CA19-9 for Liquid Biopsy-Based Detection of PDAC

Min Woo Kim et al.

Summary: The study identified 5 miRNAs that are highly expressed in PDEs, along with CA19-9, as valuable biomarkers for differentiating PDAC patients from normal controls. The combination of miRNA signatures and CA19-9 showed high sensitivity and specificity, making it a promising approach for screening and diagnosing pancreatic cancer through liquid biopsy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pathology

The role of glycometabolic plasticity in cancer

Yuyang Peng et al.

Summary: Glycometabolic plasticity, characterized by the ability of cancer cells to modulate glycometabolism in response to different stimuli, plays a key role in cancer progression, metastasis, and treatment resistance. Understanding the molecular mechanisms of glycometabolic plasticity in cancer is crucial for cancer research and treatment.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Review Biochemistry & Molecular Biology

Sensing and Signaling of Methionine Metabolism

Linda Lauinger et al.

Summary: The availability of the amino acid methionine plays a crucial role in the physiology of individual cells and whole organisms, particularly in cancer cells and healthy lifespan. Cells need mechanisms to sense methionine availability, and respond through transcriptional and signaling states to maintain metabolic balance and genomic integrity during methionine starvation conditions.

METABOLITES (2021)

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Article Multidisciplinary Sciences

Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC

Takahito Ohshiro et al.

Summary: Epitranscriptomics focuses on RNA base modifications and their functional changes to the transcriptome. A single-molecule quantum sequencer was proposed to map RNA base modifications in microRNAs related to cancer cell behavior. The study found that cytidine and adenosine methylation ratios are influenced by the presence of vicinal methylation.

SCIENTIFIC REPORTS (2021)

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Review Oncology

Oncogenic KRAS: Signaling and Drug Resistance

Hyeon Jin Kim et al.

Summary: KRAS is an oncogenic protein in human cancers, with abnormal mutated and GTP-bound KRAS being highly expressed. Understanding the biological characteristics and precise signaling of KRAS proteins is essential for targeted cancer therapy. The review also explores the recent progress in KRAS-targeted anticancer, providing new insight for cancer therapy.

CANCERS (2021)

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Article Oncology

Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment

Sai Preethi Nakkina et al.

Summary: Pancreatic cancer has a low survival rate and is the fourth leading cause of cancer death in the United States. Targeting polyamine metabolism in the tumor microenvironment may be a potential strategy to inhibit pancreatic tumor progression. Studies have shown that polyamine blockade therapy can increase survival and modulate the tumor microenvironment in pancreatic cancer.

CANCERS (2021)

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Article Oncology

BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma

Han Chen et al.

Summary: The presence of cancer stem cells in hepatocellular carcinoma is closely related to bone morphogenic protein 9 (BMP9) signaling. High BMP9 expression leads to poorer outcomes in HCC patients, while BMP9 promotes CSC properties in a specific subtype of HCC. Inhibitors of BMP receptors have therapeutic potential in treating HCC by blocking BMP9 signaling and suppressing CSC activation.

MOLECULAR ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Exploratory Study Using Urinary Volatile Organic Compounds for the Detection of Hepatocellular Carcinoma

Ayman S. Bannaga et al.

Summary: This study investigated the pattern and composition of urinary volatile organic compounds (VOCs) in HCC patients, showing that GC-IMS and GC-TOF-MS analysis can effectively identify HCC cases. The findings enhanced understanding of the pathogenesis of HCC.

MOLECULES (2021)

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Article Chemistry, Analytical

Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers

Heena Tyagi et al.

Summary: Bladder cancer and prostate cancer are commonly diagnosed with invasive techniques, but a non-invasive diagnostic approach using volatile organic compounds (VOCs) shows promise. Analysis of urinary VOC profiles using GC-IMS and GC-TOF-MS can effectively distinguish between BCa and PCa, offering potential for cancer diagnosis.

BIOSENSORS-BASEL (2021)

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Article Medicine, General & Internal

Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression

Kai Chen et al.

Summary: This study utilized single-cell RNA sequencing to explore the dynamic changes of tumor microenvironment components during PDAC malignant progression, revealing gradual accumulation of immune cells and pancreatic stellate cells. New Treg and exhausted T cell signature genes were identified, and patients with high expression of certain genes had significantly worse prognosis. A new subset of CAFs specific to PDAC, csCAFs, was also discovered.

EBIOMEDICINE (2021)

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Article Oncology

Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer

Rumi Itoyama et al.

Summary: Cancer cells, particularly pancreatic ductal adenocarcinoma cells, adapt their energy metabolism in response to nutrient deprivation in the microenvironment. Serine starvation leads to metabolic reprogramming in PDAC cells, with high plasma serine levels associated with PHGDH overexpression in tumors. Targeting the serine biosynthesis pathway by inhibiting PHGDH shows promise as a therapeutic strategy in nutrient-deprived microenvironments for PDAC.

CANCER LETTERS (2021)

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Article Biochemistry & Molecular Biology

mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex

Martin Schuele et al.

Summary: Dysregulated mTOR activity is linked to various neurodevelopmental disorders, emphasizing the importance of maintaining mTOR activity within a physiological range for brain development and function. mTOR regulates cellular processes such as cell growth, autophagy, and metabolism. The mTORC1 complex is a key transcriptional regulator of sterol/cholesterol biosynthesis genes in the developing brain, suggesting a significant metabolic role for the mTORC1 signaling pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis

Zeyin Rong et al.

Summary: Extensive studies have shown that circEYA3 is upregulated in PDAC and associated with poor prognosis. CircEYA3 promotes PDAC progression by enhancing c-Myc expression, suggesting it could be a potential therapeutic target for PDAC.

MOLECULAR CANCER (2021)

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Article

Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer

Ayumu Asai et al.

Oncotarget (2021)

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Article Cell Biology

Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response

Yu Wang et al.

Summary: The study investigated the heterogeneity among PDAC patients in terms of CAFs, ductal cancer cells, and immune cells, revealing differences between dense-type and loose-type PDAC. A novel subtype of CAFs, meCAFs, was discovered in loose-type PDAC, playing a critical role in disease progression and response to immunotherapy. This finding highlights the importance of considering intertumoral heterogeneity in PDAC treatment strategies.

CELL DISCOVERY (2021)

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Review Cell Biology

Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer

Xinglong Geng et al.

Summary: The roles of CAFs in PDAC are diverse, with different subtypes supporting or inhibiting cancer cell proliferation. As research progresses, CAFs may be a key factor in the treatment of pancreatic cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

The MicroRNA Family Gets Wider: The IsomiRs Classification and Role

Luisa Tomasello et al.

Summary: MicroRNAs are a common type of non-coding RNAs involved in various cellular processes, with dysregulation associated with diseases such as cancer. Epitranscriptomics, a branch of epigenomics, explores RNA modifications occurring post-DNA transcription, with new high-throughput technologies aiding the discovery of isomiRs. These newly discovered RNA isoforms, differing from canonical miRNAs, play an active role in cancer and other diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Serum miRNA Profiling for Early PDAC Diagnosis and Prognosis: A Retrospective Study

Ada Aita et al.

Summary: Analysis of serum miRNAs in pancreatic cancer patients identified potential biomarkers for early diagnosis and prognosis prediction. Some miRNAs were associated with lymph-node metastases and cancer progression pathways.

BIOMEDICINES (2021)

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Review Medicine, General & Internal

Arginine metabolism: a potential target in pancreatic cancer therapy

Jin-Shou Yang et al.

Summary: PDAC is an extremely malignant disease with a low survival rate, with arginine metabolism playing a crucial role in its development and progression. Arginine deprivation is considered a potential therapy, but drug resistance may develop during treatment. Arginase 1 may be a potential target for cancer immunotherapy.

CHINESE MEDICAL JOURNAL (2021)

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Article Oncology

Microbial dysbiosis and polyamine metabolism as predictive markers for early detection of pancreatic cancer

Roberto Mendez et al.

CARCINOGENESIS (2020)

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Review Oncology

One-carbon metabolism for cancer diagnostic and therapeutic approaches

Ayumu Asai et al.

CANCER LETTERS (2020)

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Article Biochemistry & Molecular Biology

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer

Yao Kong et al.

MOLECULAR CANCER (2020)

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Review Gastroenterology & Hepatology

Pancreatic cancer stroma: an update on therapeutic targeting strategies

Abdel N. Hosein et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Methionine Dependence of Cancer

Peter Kaiser

BIOMOLECULES (2020)

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Article Oncology

Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma

Caitlin A. McIntyre et al.

CANCER (2020)

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Article Multidisciplinary Sciences

Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity

Yehuda Schlesinger et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA

Gulfem D. Guler et al.

NATURE COMMUNICATIONS (2020)

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Article Genetics & Heredity

Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions

Wei Lin et al.

GENOME MEDICINE (2020)

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Article Multidisciplinary Sciences

Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice

Marta Caceres et al.

SCIENTIFIC REPORTS (2020)

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Article Environmental Sciences

Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma

Miguel Porta et al.

ENVIRONMENTAL RESEARCH (2020)

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Review Oncology

Significant epitranscriptomes in heterogeneous cancer

Masamitsu Konno et al.

CANCER SCIENCE (2019)

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Article Cell Biology

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Junya Peng et al.

CELL RESEARCH (2019)

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Review Oncology

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

Ali S. Alzahrani

SEMINARS IN CANCER BIOLOGY (2019)

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Article Oncology

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

Ela Elyada et al.

CANCER DISCOVERY (2019)

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Article Multidisciplinary Sciences

Distinct methylation levels of mature microRNAs in gastrointestinal cancers

Masamitsu Konno et al.

NATURE COMMUNICATIONS (2019)

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Review Gastroenterology & Hepatology

ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts

Grace H. Elta et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2018)

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Review Gastroenterology & Hepatology

Intraductal Papillary Mucinous Neoplasms of the Pancreas: Current Understanding and Future Directions for Stratification of Malignancy Risk

Annabelle L. Fonseca et al.

PANCREAS (2018)

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Article Multidisciplinary Sciences

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

Sharathchandra Arandkar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

Silvia Ottaviani et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis

Jun Koseki et al.

SCIENTIFIC REPORTS (2018)

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Article Cell Biology

Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells

Keisuke Tamari et al.

CELL DEATH DISCOVERY (2018)

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Article Multidisciplinary Sciences

Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2

Ayumu Asai et al.

HELIYON (2018)

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Article Multidisciplinary Sciences

Discovery and characterization of the feline miRNAome

Alessandro Lagana et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

CD13hi Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma

Jing Zhang et al.

ONCOIMMUNOLOGY (2017)

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Review Oncology

Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation

Shunsuke Kitajima et al.

CANCER SCIENCE (2017)

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Review Cell Biology

One-Carbon Metabolism in Health and Disease

Gregory S. Ducker et al.

CELL METABOLISM (2017)

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Article Biochemistry & Molecular Biology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger et al.

CELL (2016)

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Review Pharmacology & Pharmacy

KRAS-related proteins in pancreatic cancer

Karen M. Mann et al.

PHARMACOLOGY & THERAPEUTICS (2016)

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Review Biotechnology & Applied Microbiology

Biomarkers in pancreatic adenocarcinoma: current perspectives

Douglas S. Swords et al.

ONCOTARGETS AND THERAPY (2016)

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Article Multidisciplinary Sciences

BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

Toshinori Sueda et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer

Masaaki Miyo et al.

SCIENTIFIC REPORTS (2016)

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Article Medicine, General & Internal

Pancreatic cancer

Jorg Kleeff et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

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Article Multidisciplinary Sciences

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

Hugh Colvin et al.

SCIENTIFIC REPORTS (2016)

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Article Oncology

Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells

Stacey L. Borrego et al.

CANCER & METABOLISM (2016)

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Review Oncology

Circular RNA: A new star of noncoding RNAs

Shibin Qu et al.

CANCER LETTERS (2015)

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Article Oncology

Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating β-oxygenation pathway in colorectal cancer

Jun Koseki et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Review Oncology

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

Ruth Nussinov et al.

MOLECULAR CANCER RESEARCH (2015)

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Article Oncology

Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system for proteasome activity

Keisuke Tamari et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Oncology

Visualization and characterization of cancer stem-like cells in cervical cancer

Kazuhiko Hayashi et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Article Cell Biology

S-adenosylmethionine limitation induces p38 mitogen-activated protein kinase and triggers cell cycle arrest in G1

Da-Wei Lin et al.

JOURNAL OF CELL SCIENCE (2014)

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Review Oncology

Targeting PI3K/Akt/mTOR signaling in cancer

Camillo Porta et al.

FRONTIERS IN ONCOLOGY (2014)

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Review Genetics & Heredity

Long Noncoding RNAs: Past, Present, and Future

Johnny T. Y. Kung et al.

GENETICS (2013)

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Article Multidisciplinary Sciences

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son et al.

NATURE (2013)

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Article Cell Biology

Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells

Keith Booher et al.

CELL CYCLE (2012)

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Article Multidisciplinary Sciences

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Christian M. Metallo et al.

NATURE (2012)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

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