Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action

Article Oncology

Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives

Elina Khatoon et al.

Summary: Despite advances in cancer treatment, drug resistance remains a major challenge. Phytochemicals have emerged as potential chemosensitizing agents due to their multitargeted properties and low toxicity.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Biochemistry & Molecular Biology

Drug Combinations: A New Strategy to Extend Drug Repurposing and Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells

Diana Duarte et al.

Summary: Despite research advancement in drug therapy for solid tumors, cancer remains a major health problem. Drug repurposing and combination strategies have gained interest. A novel drug combination using different CNS drugs and DOX was proposed and studied in MCF-7 breast cancer cells. Immunohistochemistry results suggest that these treatments could induce EMT reversal.

BIOMOLECULES (2022)

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Article Microbiology

InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in In Vitro Infection Assays

Ana C. Magalhaes et al.

Summary: The study proposes a histology-based method for evaluating infection kinetics and demonstrates the advantages of InfectionCMA, which allows for side-by-side comparisons and evaluation of diverse cell lines, infection time points, and biomarker expression.

PATHOGENS (2022)

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Review Biology

Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein

Chenmala Karthika et al.

Summary: P-gp plays a major role in multidrug resistance in cancer cells. Despite significant efforts, there are currently no effective drugs to block P-gp-mediated resistance. However, its protective function in normal cells should not be overlooked.

LIFE-BASEL (2022)

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Article Chemistry, Multidisciplinary

Enhanced lysosomal function is critical for paclitaxel resistance in cancer cells: reversed by artesunate

Zhe Li et al.

Summary: The mechanisms of resistance to chemotherapy drugs vary in cancer cells, with lysosomal function playing a significant role. Artesunate has been shown to impact lysosomal function, potentially affecting the resistance of cancer cells to drugs. This study suggests that targeting lysosomal function, using compounds like artesunate, could be a potential treatment for drug-resistant cancer cells.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Biochemistry & Molecular Biology

How Antimalarials and Antineoplastic Drugs can Interact in Combination Therapies: A Perspective on the Role of PPT1 Enzyme

Diana Duarte et al.

Summary: Antimalarial drugs have shown anticancer effects in various cancer cells, with PPT1 identified as a molecular target for chloroquine. The overexpression of PPT1 in different cancers suggests its potential as a target for therapy. The interaction between antimalarial drugs and antineoplastic drugs in breast cancer cells indicates the potential for synergistic effects in cancer treatment.

CURRENT DRUG METABOLISM (2021)

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Review Endocrinology & Metabolism

The Role of Ki67 in Evaluating Neoadjuvant Endocrine Therapy of Hormone Receptor-Positive Breast Cancer

Ailin Zhang et al.

Summary: Ki67, a proliferation marker, is proposed for breast cancer subtype classification, prognosis, and therapeutic response prediction. However, its questionable analytical validity hinders its widespread adoption in treatment decisions for breast cancer. Studies have shown potential for Ki67 as a predictive marker in neoadjuvant endocrine therapy.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines With Increased Expression of P-Glycoprotein

Mariana Nunes et al.

Summary: Debulking surgery followed by chemotherapy is the standard treatment for high-grade serous carcinoma, but most patients eventually develop chemoresistance leading to poor survival rates. Researchers established two high-grade serous carcinoma cell lines with intrinsic resistance to Carboplatin and induced resistance to Paclitaxel, providing a valuable tool for studying drug resistance mechanisms and testing new therapeutic strategies.

FRONTIERS IN ONCOLOGY (2021)

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Review Multidisciplinary Sciences

The converging roles of Batten disease proteins in neurodegeneration and cancer

Shyong Quan Yap et al.

Summary: Epidemiological studies have shown a negative correlation between cancer and neurodegenerative disorders. Genetic convergence of NCLs and other neurodegenerative diseases prompts exploration of their relationship with cancer. Research on the role of NCL genes in oncogenic processes and cancer immunology may provide insights for therapy development in both diseases.

ISCIENCE (2021)

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Article Biochemistry & Molecular Biology

Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs

Diana Duarte et al.

Summary: The study found that fluphenazine, fluoxetine, and benztropine showed enhanced anticancer activity when used alone in colorectal cancer; sertraline was identified as a promising candidate for drug repurposing in breast cancer; sertraline and thioridazine in combination with 5-FU exhibited the strongest synergism in colorectal cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Old wine in new bottles: Drug repurposing in oncology

Michal Antoszczak et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Nanoscience & Nanotechnology

Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer

Elaheh Entezar-Almahdi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Pharmacology & Pharmacy

Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

Nuray Erin et al.

DRUG RESISTANCE UPDATES (2020)

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Article Biochemistry & Molecular Biology

New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells

Diana Duarte et al.

BIOMOLECULES (2020)

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Article Integrative & Complementary Medicine

In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts

Marco Mellado et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Article Biology

A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

Adam C. Palmer et al.

ELIFE (2019)

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Article Oncology

PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer

Vito W. Rebecca et al.

CANCER DISCOVERY (2019)

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Article Oncology

Resistance to paclitaxel is associated with a variant of the gene BCL2 in multiple tumor types

Rotem Ben-Hamo et al.

NPJ PRECISION ONCOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Role of the NFκB-signaling pathway in cancer

Longzheng Xia et al.

ONCOTARGETS AND THERAPY (2018)

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Article Chemistry, Multidisciplinary

Epigallocatechin gallate-zinc oxide co-crystalline nanoparticles as an anticancer drug that is non-toxic to normal cells

Pawatsanai Samutprasert et al.

RSC ADVANCES (2018)

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Review Agriculture, Multidisciplinary

Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy

Angela R. Guerra et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Review Immunology

Mechanisms of NF-kappa B p65 and strategies for therapeutic manipulation

Sivagami Giridharan et al.

JOURNAL OF INFLAMMATION RESEARCH (2018)

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Article Oncology

Lysosome Inhibitors Enhance the Chemotherapeutic Activity of Doxorubicin in HepG2 Cells

Yuyin Li et al.

CHEMOTHERAPY (2017)

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Article Endocrinology & Metabolism

Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-B/iNOS signaling pathways

Yue Gao et al.

JOURNAL OF PINEAL RESEARCH (2017)

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Review Biochemistry & Molecular Biology

PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs

Luyao Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Oncology

5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin

Kaja Lund et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

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Article Chemistry, Medicinal

Synergistic Activity of an Antimetabolite Drug and Tyrosine Kinase Inhibitors against Breast Cancer Cells

Yushan Wu et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2017)

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Review Pharmacology & Pharmacy

Recent advances of cocktail chemotherapy by combination drug delivery systems

Quanyin Hu et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Oncology

Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells

Baoqing Guo et al.

BMC CANCER (2016)

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Article

P-glycoprotein and its role in drug-drug interactions

Andrew Finch et al.

Australian Prescriber (2016)

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Review Pharmacology & Pharmacy

Multidrug Resistance Proteins (MRPs) and Cancer Therapy

Yun-Kai Zhang et al.

AAPS JOURNAL (2015)

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Article Pharmacology & Pharmacy

Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21

Liufeng Mei et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

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Article Chemistry, Medicinal

Cytotoxicity screening of essential oils in cancer cell lines

Pollyanna Francielli de Oliveira et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2015)

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Article Chemistry, Medicinal

Cytotoxicity screening of essential oils in cancer cell lines

Pollyanna Francielli de Oliveira et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2015)

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Review Oncology

Ki67 is a promising molecular target in the diagnosis of cancer

Lian Tao Li et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Biochemistry & Molecular Biology

The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice

Jasmin Kranz et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2014)

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Article Oncology

Association of-24CT, 1249GA, and 3972CT ABCC2 Gene Polymorphisms with Methotrexate Serum Levels and Toxic Side Effects in Children with Acute Lymphoblastic Leukemia

Mohamad Jafar Sharifi et al.

PEDIATRIC HEMATOLOGY AND ONCOLOGY (2014)

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Article Multidisciplinary Sciences

Synergistic Anti-Cancer Effect of Phenformin and Oxamate

W. Keith Miskimins et al.

PLOS ONE (2014)

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Article Oncology

Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in oesophageal squamous cell carcinoma

M. Yamasaki et al.

BRITISH JOURNAL OF CANCER (2011)

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Editorial Material Biotechnology & Applied Microbiology

Doxorubicin pathways: pharmacodynamics and adverse effects

Caroline F. Thorn et al.

PHARMACOGENETICS AND GENOMICS (2011)

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Article

PARP inhibitors: its role in treatment of cancer

Alice Chen

Chinese Journal of Cancer (2011)

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Article Cell Biology

Cell Growth Inhibition, G(2)/M Cell Cycle Arrest, and Apoptosis Induced by Chloroquine in Human Breast Cancer Cell Line Bcap-37

Pei-du Jiang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2008)

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Review Pharmacology & Pharmacy

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

Ting-Chao Chou

PHARMACOLOGICAL REVIEWS (2006)

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Review Biochemistry & Molecular Biology

Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition

Gabriele Jedlitschky et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)

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Article Oncology

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid

MT Huisman et al.

INTERNATIONAL JOURNAL OF CANCER (2005)

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Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action

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