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Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?

BIOMOLECULES (2022)

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Summary: This study demonstrates the potential of a novel nanoparticle delivery system for targeted and sustained release of IGF-1, leading to improved motor recovery through amelioration of denervation-induced muscle atrophy and SC senescence and enhanced axonal regeneration.

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A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

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Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

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H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve

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Soluble Neuregulin-1 Has Bifunctional, Concentration-Dependent Effects on Schwann Cell Myelination

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Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes

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A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation

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Transforming growth factor β (TGFβ) mediates schwann cell death in vitro and in vivo:: Examination of c-jun activation, interactions with survival signals, and the relationship of TGFβ-mediated death to schwann cell differentiation

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