期刊
BIOMOLECULES
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biom12091257
关键词
proteolysis-targeting chimeras; protein degradation technology; E3 ligase; protein of interest
资金
- National Natural Science Foundation of China [81502065, 81672926, 81972793]
- Natural Science Foundation of Shandong Province, China [ZR2021MC039]
This article introduces PROTAC technology and the recent advances in novel degradation technologies based on this mechanism. It discusses the clinical progress, current challenges, and future prospects of degradation technologies based on the PROTAC mechanism.
PROTAC (proteolysis-targeting chimeras), which selectively degrades target proteins, has become the most popular technology for drug development in recent years. Here, we introduce the history of PROTAC, and summarize the recent advances in novel types of degradation technologies based on the PROTAC mechanism, including TF-PROTAC, Light-controllable PROTAC, PhosphoTAC, LYTAC, AUTAC, ATTEC, CMA, RNA-PROTAC and RIBOTACs. In addition, the clinical progress, current challenges and future prospects of degradation technologies based on PROTAC mechanism are discussed.
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