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Article
Infectious Diseases
Kevin B. Spicer et al.
Summary: This study shows that natural infection provides substantial and persistent immunologic protection for several months for most individuals, although certain subpopulations may be at higher risk of reinfection. These subgroups include individuals aged >60 years, residents and staff of long-term care facilities, and those who have mild or asymptomatic illness with initial infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Sezanur Rahman et al.
Summary: This study investigated the rate of SARS-CoV-2 infection and its clinical features among infection-naive, infected, vaccinated, and post-infection-vaccinated individuals. The findings showed that naturally infected populations were less likely to be reinfected by SARS-CoV-2 than individuals who were infection-naive or vaccinated. However, a significant proportion of naturally infected or vaccinated individuals were (re)-infected by the emerging variants.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Huoba Li et al.
Summary: This study aimed to investigate the knowledge and willingness of geriatric care facility staff to receive a COVID-19 vaccine and provide a basis for government promotion and guidance. The results showed that most participants had good knowledge and willingness to receive the vaccine, but there were still some with poor knowledge and unwillingness. Government can enhance publicity to increase vaccination rates.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
Amelia G. Johnson et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Immunology
Mateusz Babicki et al.
Summary: COVID-19 vaccine booster dose has received attention in Poland. The study found that while the majority of respondents were willing to receive the booster dose, one in three respondents planned to delay or refuse it. Lack of confidence in the effectiveness of the booster dose and the belief that previous vaccination provides sufficient protection were the main reasons for refusal to be vaccinated.
Review
Medicine, General & Internal
Mohd Noor Norhayati et al.
Summary: Vaccination is crucial in controlling the COVID-19 pandemic. This study analyzed the global vaccine acceptance rate and found a pooled proportion of 61%. However, there is a need to enhance public awareness and increase vaccine uptake to achieve herd immunity.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Cristina Menni et al.
Summary: This study aimed to investigate the effectiveness and waning of COVID-19 primary vaccine series, as well as the safety and effectiveness of booster doses. The results showed that vaccine effectiveness decreased after the second dose, but booster doses restored effectiveness. However, heterologous booster regimens had more systemic side-effects.
LANCET INFECTIOUS DISEASES
(2022)
Editorial Material
Medicine, General & Internal
Chris Stokel-Walker
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Critical Care Medicine
Sara Y. Tartof et al.
Summary: This study evaluated the effectiveness and durability of two and three doses of the BNT162b2 (Pfizer-BioNTech) mRNA vaccine against hospital and emergency department admissions due to the delta and omicron variants. The results showed that three doses of the vaccine provided high protection against both variants in the first 3 months after vaccination, but waning was observed against the omicron variant after 3 months. Additional doses of vaccines might be needed to maintain high levels of protection against future variants.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Immunology
Mateusz Babicki et al.
Summary: This study assessed the main concerns of the unvaccinated population in Poland and found that the public is primarily concerned about vaccine adverse events and the lack of appropriate testing. As the vaccination program continued, there was an increase in the percentage of individuals declaring their full reluctance towards COVID-19 vaccination. The study suggests focusing on the Internet as the main source of knowledge and promoting reliable information about the vaccination.
Article
Medicine, General & Internal
Ramandip Grewal et al.
Summary: This study estimated the marginal effectiveness of a fourth dose compared to a third dose of mRNA covid-19 vaccines and the vaccine effectiveness of BNT162b2 and mRNA-1273 vaccines against the omicron variant. The results showed that a fourth dose improved protection against infection, symptomatic infection, and severe outcomes. Vaccine effectiveness increased with each additional dose.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Microbiology
Brian J. Willett et al.
Summary: Vaccines based on the spike protein of SARS-CoV-2 are vital in combating COVID-19, but the emergence of the Omicron variant poses a threat to this strategy. Studies have shown that the Omicron variant evades neutralization by sera from individuals vaccinated with different vaccines and reduces real-world vaccine effectiveness, although booster vaccination can partially restore its effectiveness. Additionally, the Omicron variant exhibits distinct cell entry pathways and phenotypes, which may contribute to its rapid global spread and altered pathogenicity.
NATURE MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Isobel L. Ward et al.
Summary: Based on a retrospective cohort study conducted in England from December 1, 2021 to December 30, 2021, the risk of covid-19 death was found to be reduced by 66% for omicron BA.1 compared to delta. The reduction in risk was more pronounced in the 18-59 year age group.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Review
Medicine, General & Internal
Fidelia Cascini et al.
Summary: Social media has the potential to shape attitudes towards COVID-19 vaccination and can be used to address vaccine hesitancy.
Article
Medicine, General & Internal
Einav G. Levin et al.
Summary: A study in Israel revealed that waning immunity after receiving two doses of the BNT162b2 vaccine led to an increase in the incidence of SARS-CoV-2 infection. Levels of spike-binding IgG and neutralizing antibodies decreased more significantly in men, individuals aged 65 or older, and immunosuppressed individuals in a longitudinal study involving nearly 4000 healthcare workers.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Hiam Chemaitelly et al.
Summary: In a study conducted in Qatar involving over 900,000 participants, vaccine effectiveness peaked at 77.5% in the first month after the second dose. However, it declined afterwards to as low as 20% in months 5 through 7 after vaccination, while protection against severe Covid-19 remained above 90% for at least 6 months.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Sophie Mylan et al.
Review
Immunology
Chih-Cheng Lai et al.
Summary: Four vaccines have been granted emergency use authorization, 87 are in clinical development, and 186 are in pre-clinical development. The development of COVID-19 vaccines is rapidly progressing, but the benefits must outweigh the potential risks. Collaboration between clinicians, healthcare authorities, and manufacturers is essential for successful vaccination programs to control the COVID-19 pandemic.
EXPERT REVIEW OF VACCINES
(2021)
Letter
Medicine, General & Internal
Ilies Benotmane et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
