Plant Molecular Pharming and Plant-Derived Compounds towards Generation of Vaccines and Therapeutics against Coronaviruses

Article Biochemistry & Molecular Biology

Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants -Withania somnifera(Ashwagandha),Tinospora cordifolia(Giloy) andOcimum sanctum(Tulsi) - a molecular docking study

Priya Shree et al.

Summary: By utilizing molecular docking and molecular dynamics simulation, this study identifies potential phytochemicals from medicinal plants that could inhibit SARS-CoV-2 and possess drug-like properties.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Biochemistry & Molecular Biology

The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease

Wei-Chung Chiou et al.

Summary: The COVID-19 pandemic has caused a global health crisis, and developing effective treatments is crucial. This study investigates the role of SARS-CoV-2 3CLpro in viral replication and identifies natural compounds PGG and EGCG as potential inhibitors. The findings highlight the therapeutic potentials of PGG and EGCG for treating SARS-CoV-2 infection.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Immunology

Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

Stephane Pillet et al.

Summary: This study reports the immunogenicity and protection induced by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein vaccine candidate in rhesus macaques, formulated with or without Adjuvant System 03 or cytidine-phospho-guanosine. The AS03-adjuvanted CoVLP showed higher immunogenicity and protection compared to other formulations, and was selected for vaccine development and clinical trials.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Review Nutrition & Dietetics

The coronavirus disease (COVID-19) - A supportive approach with selected micronutrients

Uwe Grober et al.

Summary: In the context of the COVID-19 pandemic, elderly and other vulnerable groups are more likely to suffer from malnutrition, making them more susceptible to infections. Nutrition plays a crucial role in immune function, and certain micronutrients like vitamin D and zinc can enhance the physiological resilience of the immune system against COVID-19.

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (2022)

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Review Biochemistry & Molecular Biology

p38 activation and viral infection

Luyao Wang et al.

Summary: Understanding the molecular and cellular mechanisms of viral infections is crucial for preventing and treating viral diseases. The p38 MAPK signaling pathway plays an important role in viral infections, and studying its activation can provide insights for developing antiviral strategies.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2022)

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Review Immunology

Plant-Based Vaccines in Combat against Coronavirus Diseases

Benita Ortega-Berlanga et al.

Summary: Coronavirus vaccines have become increasingly important, especially with the COVID-19 pandemic. Plant systems provide a low-cost and scalable method for producing coronavirus proteins, which can be used for injection vaccines or as mucosal or oral vaccines.

VACCINES (2022)

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Article Biology

Plant-Derived Recombinant Vaccines against Zoonotic Viruses

Gergana Zahmanova et al.

Summary: Vaccination is the most effective way to restrict the spread of zoonotic viruses and prevent diseases. Recombinant proteins produced in plants offer a safe, effective, and inexpensive approach for vaccine development. Virus-like particles (VLPs) produced in plants, which can self-assemble and resemble the form of virus particles, are gaining popularity as candidate vaccines against various infectious diseases.

LIFE-BASEL (2022)

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Article Medicine, Research & Experimental

Adamalysins in COVID-19-Potential mechanisms behind exacerbating the disease

Ivo Ricardo de Seabra Rodrigues Dias et al.

Summary: COVID-19, caused by the SARS-CoV-2 virus, is a global pandemic with millions of cases and deaths. Investigating the functions of adamalysins in disease, particularly COVID-19, could provide insights into the molecular mechanisms of the disease and potential therapeutic targets. Understanding these mechanisms may also help in monitoring and managing rare severe side effects of COVID-19 vaccines. Overall, this review highlights the importance of studying adamalysins in disease.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Medicine, General & Internal

Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine

Karen J. Hager et al.

Summary: The CoVLP+AS03 vaccine showed efficacy in preventing Covid-19 caused by different variants, with efficacy ranging from 69.5% against symptomatic infection to 78.8% against moderate-to-severe disease.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Immunology

Broad neutralization against SARS-CoV-2 variants induced by ancestral and B.1.351 AS03-Adjuvanted recombinant Plant-Derived Virus-Like particle vaccines

Charlotte Dube et al.

Summary: Since 2019, the global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, leading to coronavirus disease 2019 (COVID-19), has affected hundreds of millions of people. Safe and effective COVID-19 vaccines are now available, but the emergence of variants and the risk of viral escape from vaccine-induced immunity require the development of broadly protective vaccines. A plant-derived virus-like particle vaccine was assessed in mice and shown to induce strong and broadly cross-reactive neutralizing antibody responses against various variants.

VACCINE (2022)

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Article Pharmacology & Pharmacy

Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 mice

Eun-Ha Kim et al.

Summary: The study suggests that phytochemicals extracted from Chlorella spp. and Psidium guajava have broad-spectrum antiviral activity against multiple SARS-CoV-2 variants and demonstrate potential anti-inflammatory activity.

ANTIVIRAL RESEARCH (2022)

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Article Immunology

Broad neutralization against SARS-CoV-2 variants induced by ancestral and B.1.351 AS03-Adjuvanted recombinant Plant-Derived Virus-Like particle vaccines

Charlotte Dube et al.

Summary: A study on mouse models showed that both the ancestral COVID-19 vaccine and the modified B.1.351 variant vaccine induced strong and broadly cross-reactive neutralizing antibody (NAb) responses against various Variants of Concern (VOCs), including Delta and Omicron strains.

VACCINE (2022)

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Article Biochemistry & Molecular Biology

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants

Gideon A. Gyebi et al.

Summary: The study screened alkaloids and terpenoids from African plants as potential inhibitors of coronavirus 3CL(pro). Over half of the top twenty compounds showed favorable interactions with coronaviruses 3CL(pro) and higher binding affinities than lopinavir and ritonavir. Seven promising compounds were identified, including four non-toxic, druggable plant-derived alkaloids and terpenoids that bind to the receptor-binding site and catalytic dyad of SARS-CoV-2 3CL(pro). Further experimental analyses are needed for developing these compounds as natural anti-COVID-19 therapeutic agents.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Stilbene-based natural compounds as promising drug candidates against COVID-19

Hussain Mustatab Wahedi et al.

Summary: The study suggests that stilbenoid compounds, especially resveratrol, could be promising candidates for anti-COVID-19 drugs by disrupting the structure of the viral protein.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Review Infectious Diseases

Genetic comparison among various coronavirus strains for the identification of potential vaccine targets of SARS-CoV2

Navpreet Kaur et al.

Summary: The ongoing COVID-19 pandemic has become a global public health emergency, prompting urgent research into therapeutic and preventive interventions. Global efforts are focused on understanding the origin and evolutionary history of SARS-CoV2 to develop potential treatments and prevention strategies.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Biochemistry & Molecular Biology

Sars-cov-2 host entry and replication inhibitors from Indian ginseng: anin-silicoapproach

Rupesh Chikhale et al.

Summary: This study identified potential compounds from Indian ginseng that may serve as promising inhibitors for treating COVID-19, as they showed favorable interactions at binding sites with SARS-CoV-2 proteins and demonstrated high binding free energy in molecular dynamics simulations.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Article Biochemistry & Molecular Biology

Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: anin silicostudy for drug development

Preeti Pandey et al.

Summary: This study investigated the interaction of 10 potential naturally occurring compounds with the SARS-CoV-2 spike protein, indicating their potential to disrupt the binding of the hACE2-S complex. Molecular docking studies and molecular dynamics simulation suggested that flavonoids and non-flavonoids may serve as anti-SARS-CoV-2 agents with drug-likeness properties.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Chemistry, Medicinal

Natural products forCOVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies

Motahareh Boozari et al.

Summary: This review discusses the potential role of natural products in the treatment of COVID-19, suggesting promising herbal treatment options and highlighting the antiviral and immune-boosting effects of natural products against coronaviruses.

PHYTOTHERAPY RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Biomimetic Virus-Like Particles as Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostic Tools

Soo Khim Chan et al.

Summary: COVID-19 is a highly transmissible disease affecting majority of countries globally. The use of nucleic acid tests, especially RT-PCR, has become essential for early detection of infection. Generating biomimetic virus-like particles as positive controls can overcome the need for cold-chain distribution, providing reliable, scalable, and stable controls for clinical settings.

ACS NANO (2021)

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Review Microbiology

Similarities and Dissimilarities of COVID-19 and Other Coronavirus Diseases

To Sing Fung et al.

Summary: Three deadly zoonotic coronaviruses, including SARS-CoV, MERS-CoV, and SARS-CoV-2, have emerged in humans in less than two decades, leading to severe respiratory diseases. The COVID-19 pandemic has caused a crisis in global health care and socio-economic development, highlighting the constantly evolving nature of coronaviruses. Understanding the pathogenic mechanisms and host immune responses is crucial in developing effective strategies for prevention and treatment.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021 (2021)

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Review Virology

The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

Nima Hemmat et al.

Summary: The number of descriptions of emerging viruses has increased rapidly since the beginning of the 21st century. SARS-CoV-2 may cause inflammation at the onset of COVID-19 through NF-kappa B, cytokine regulation, ERK, and TNF-alpha signaling pathways. Some drugs have been used to alleviate the adverse effects of inflammatory cellular signaling pathways and may be beneficial for developing novel therapeutic modalities against COVID-19.

ARCHIVES OF VIROLOGY (2021)

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Article Biology

Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing

Pandikannan Krishnamoorthy et al.

Summary: Research found that common pathways are activated and suppressed in SARS-CoV, MERS-CoV, and SARS-CoV-2 at the same time point and cell line, aiding in identifying potential drug treatments for COVID-19. Similar pathway enrichment was also found in an in-vivo transcriptomic dataset of COVID-19 patients.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Article Plant Sciences

Development of Plant-Produced Recombinant ACE2-Fc Fusion Protein as a Potential Therapeutic Agent Against SARS-CoV-2

Konlavat Siriwattananon et al.

Summary: SARS-CoV-2, the causative agent of COVID-19, enters host cells using ACE2. The plant-produced ACE2-Fc fusion protein demonstrates potent anti-SARS-CoV-2 activity in vitro, showing promise as a potential therapeutic candidate against the virus.

FRONTIERS IN PLANT SCIENCE (2021)

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Review Immunology

Plant-Based Drugs and Vaccines for COVID-19

Nasir Mahmood et al.

Summary: The coronavirus pandemic has disrupted our lives, but research on vaccines and antivirals is ongoing, with plant production platforms being utilized for mass production of vaccines and antiviral proteins.

VACCINES (2021)

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Article Biochemical Research Methods

Virtual screening and molecular dynamics simulation study of plant-derived compounds to identify potential inhibitors of main protease from SARS-CoV-2

Shafi Mahmud et al.

Summary: The study highlights Mpro of SARS-CoV-2 as a potential drug target, with a focused approach on virtual screening of compounds from Asian plants resulting in the identification of 19 promising candidates. Among them, curcumin, gartanin, and robinetin showed the best binding energies. Molecular dynamics simulations validated the interactions and stability of these compounds with the target protein, suggesting their potential as drug candidates against SARS-CoV-2.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Biochemical Research Methods

A molecular modelling approach for identifying antiviral selenium-containing heterocyclic compounds that inhibit the main protease of SARS-CoV-2: an in silico investigation

Ahmed Rakib et al.

Summary: Selenium plays a crucial role in immune functions and selenium compounds may inhibit the activity of the main protease produced by SARS-CoV-2. Certain selenocompounds showed potential binding affinities for SARS-CoV-2 M-pro, with ethaselen identified as a promising anti-COVID-19 drug candidate.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Zhiwei Wu et al.

Summary: The study showed that CoronaVac vaccine is safe and well tolerated in older adults, and is able to induce neutralizing antibody levels. The highest dose of 3 μg of the vaccine can generate neutralizing antibody levels similar to the 6 μg dose, supporting the use of the 3 μg dose CoronaVac in phase 3 trials.

LANCET INFECTIOUS DISEASES (2021)

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Article Pharmacology & Pharmacy

Edible plant-derived exosomal microRNAs: Exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2

Sreeram Peringattu Kalarikkal et al.

Summary: A study identified 22 miRNAs derived from ENPs that could potentially target the SARS-CoV-2 genome, with 11 miRNAs showing specificity towards SARS-CoV-2. ENPs from various plants were found to possess multiple miRNAs targeting different regions within SARS-CoV-2, showing potential for development as an alternative therapy.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Chemistry, Medicinal

Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model

Acharya Balkrishna et al.

Summary: This study explored the potential of withanone as a potent inhibitor of SARS-CoV-2 coronavirus entry into the host cells through computational analysis and in vitro validation. The findings suggest that withanone may have a significant antiviral efficacy against SARS-CoV-2 infection.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Pharmacology & Pharmacy

Next-Generation COVID-19 Vaccines Should Take Efficiency of Distribution into Consideration

Khaled AboulFotouh et al.

Summary: The storage and distribution of COVID-19 vaccines pose a challenge due to the requirement for cold temperatures, but thermostabilizing technologies could enable cold chain-free vaccine storage and distribution. Efforts should be focused on developing cost-effective technologies for next-generation COVID-19 vaccines to achieve worldwide mass vaccination and eradication of the disease.

AAPS PHARMSCITECH (2021)

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Editorial Material Immunology

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

Jinghe Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Innate immune sensing of coronavirus and viral evasion strategies

Yusuke Kasuga et al.

Summary: Understanding how the innate immune system detects coronaviruses and how the viruses evade detection is crucial for developing novel strategies to combat infections. Constant evolution of coronaviruses to evade host immune responses underscores the need for in-depth research into specific viral proteins and mechanisms that suppress immunity. Targeting key receptors like TLR7 in the host immune system could be a promising therapeutic approach against coronavirus infections.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Characterization of Phytochemicals in Ulva intestinalis L. and Their Action Against SARS-CoV-2 Spike Glycoprotein Receptor-Binding Domain

Seema A. Kulkarni et al.

Summary: This study focused on using the marine microalga Ulva intestinalis to discover potential antiviral compounds against SARS-CoV-2. Experimental results showed that certain compounds from the alga exhibited high binding affinity to the spike protein of the virus, indicating their potential as effective antiviral candidates.

FRONTIERS IN CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Immunological Aspects of SARS-CoV-2 Infection and the Putative Beneficial Role of Vitamin-D

Ming-Yieh Peng et al.

Summary: Vitamin D plays a crucial role in combating COVID-19 by enhancing the immune system, increasing ACE2 expression, and inhibiting the activity of the RAS system. Medical studies have shown that adequate intake of vitamin D is inversely correlated with the incidence and severity of COVID-19.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Production and Characterization of Nucleocapsid and RBD Cocktail Antigens of SARS-CoV-2 in Nicotiana benthamiana Plant as a Vaccine Candidate against COVID-19

Tarlan Mamedov et al.

Summary: The study successfully produced promising vaccine candidates against COVID-19 in plants, leading to high-titer antibodies with potent neutralizing activity against SARS-CoV-2 in mice.

VACCINES (2021)

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Article Biochemistry & Molecular Biology

Efficacy of Phytochemicals Derived from Avicennia officinalis for the Management of COVID-19: A Combined In Silico and Biochemical Study

Shafi Mahmud et al.

Summary: This study extracted phytochemicals from Avicennia officinalis and identified four compounds with potential inhibitory effects against the main protease of SARS-CoV-2. The compounds showed high antioxidant activities and low cytotoxicity, but further validation is needed to confirm their efficacy.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

Brian J. Ward et al.

Summary: This study reported the interim safety and immunogenicity data of a plant-produced COVID-19 vaccine candidate at Day 42. The results showed good tolerability of all formulations and induction of immune responses, supporting further evaluation of the vaccine candidate.

NATURE MEDICINE (2021)

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Article Virology

Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

Koen Vandyck et al.

Summary: This article reviews first-generation SARS-CoV-2 3CLpro inhibitors PF-07304814, GC-376, and CDI-45205, which are currently being delivered either by injection or inhalation due to their low intrinsic oral bioavailability. Additionally, PF-07321332 is emerging as a promising second-generation clinical candidate for oral delivery. A key challenge in the development of novel 3CLpro inhibitors is the poor understanding of the predictive value of in vitro potency towards clinical efficacy, complicated by the involvement of host proteases in virus entry. Further preclinical and clinical validation will be crucial in establishing 3CLpro inhibitors as a bona fide class for future SARS-CoV-2 therapeutics for both hospitalized and outpatient populations.

CURRENT OPINION IN VIROLOGY (2021)

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Article Plant Sciences

SARS-CoV-2 Antigens Expressed in Plants Detect Antibody Responses in COVID-19 Patients

Mohau S. Makatsa et al.

Summary: Plant-derived recombinant viral proteins were used to develop a serological assay, successfully detecting specific immunoglobulins in patients with SARS-CoV-2. The assay also showed potential for measuring SARS-CoV-2 antibody responses in saliva samples, suggesting its valuable application in seroepidemiological studies of SARS-CoV-2.

FRONTIERS IN PLANT SCIENCE (2021)

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Article Plant Sciences

Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates

Konlavat Siriwattananon et al.

Summary: The study investigated the immunogenicity of plant-produced receptor-binding domain (RBD) of SARS-CoV-2 as a subunit vaccine. The results demonstrated the potential of plant-produced SARS-CoV-2 RBD as an effective vaccine candidate against SARS-CoV-2, showing immunogenicity in mice and non-human primates for the first time.

FRONTIERS IN PLANT SCIENCE (2021)

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Review Oncology

ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment

Nathalie Theret et al.

Summary: Members of the adamalysin family, including ADAM, ADAMTS, and ADAMTSL, play critical roles in modulating cell-cell and cell-ECM communication within the tumor microenvironment, influencing hepatocellular carcinoma progression. The tumor microenvironment, consisting of stromal cells, ECM, and cytokine/growth factors, is essential for tumor growth, invasion, and resistance to chemotherapy. Despite numerous studies supporting the involvement of adamalysins in HCC development, the functional characterization of most of them remains unresolved.

CANCERS (2021)

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Article Biology

Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors

Rahul Singh et al.

Summary: Through computational methods, Dicaffeoylquinic acid and Diacetylcurcumin were identified as potential inhibitors of SARS-CoV-2 S-RBD, suggesting further validation in in-vitro and in-vivo studies.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Florian Kabinger et al.

Summary: Molnupiravir is an oral antiviral drug candidate that increases viral RNA mutations frequency and inhibits replication of SARS-CoV-2 by altering the substrate preference of RdRp. This two-step mutagenesis mechanism can explain the broad-spectrum antiviral activity of molnupiravir, making it a promising COVID-19 treatment option.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases

Wenshu He et al.

Summary: The fight against infectious diseases often focuses on epidemics and pandemics, but the majority of deaths occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems. Challenges in vaccine provision are hampered by high costs, limited scalability, distribution, and storage issues, particularly in regions without cold chain infrastructure. Molecular farming, particularly using edible plants for oral drugs, shows promise in addressing these challenges and recent advancements have shown success in clinical trials and FDA approvals for orally delivered protein drugs.

PLANT BIOTECHNOLOGY JOURNAL (2021)

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Review Biotechnology & Applied Microbiology

Contributions of the international plant science community to the fight against human infectious diseases - part 1: epidemic and pandemic diseases

Maria Lobato Gomez et al.

Summary: Infectious diseases, caused by pathogens or parasites, pose a significant burden on global healthcare systems. Traditional approaches like vaccination and hygiene are limited by cost and scalability, particularly in developing countries. Molecular farming offers a promising solution to address these limitations and improve healthcare access worldwide.

PLANT BIOTECHNOLOGY JOURNAL (2021)

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Article Multidisciplinary Sciences

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Haixia Su et al.

Summary: The naturally occurring flavonoid myricetin is identified as a non-peptidomimetic and covalent inhibitor of SARS-CoV-2 3CL protease. Crystal structures reveal the pyrogallol group modifies the catalytic cysteine through covalent binding. This study provides insights into the mechanism of action of pyrogallol-containing natural products and offers a template for designing non-peptidomimetic covalent inhibitors against 3CL proteases.

NATURE COMMUNICATIONS (2021)

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Article Pharmacology & Pharmacy

Exploring Phytochemicals of Traditional Medicinal Plants Exhibiting Inhibitory Activity Against Main Protease, Spike Glycoprotein, RNA-dependent RNA Polymerase and Non-Structural Proteins of SARS-CoV-2 Through Virtual Screening

Saranya Nallusamy et al.

Summary: The study explores the potential of phytochemicals and antiviral molecules from various plant species in inhibiting SARS-CoV-2, highlighting the need for discovering novel drugs. Some plant compounds, such as cyanin from ginger, showed promising inhibitory activity against main proteases of SARS-CoV-2, SARS-CoV, and MERS-CoV. Identified herbal plants, including Mangifera indica and Vitex negundo, were suggested as potential sources of phytochemicals for combating COVID-19. Overall, the study emphasizes the importance of herbal medicines in drug discovery and development for treating viral diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Immunology

Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants

Sonia Budroni et al.

Summary: Differences in innate immune 'imprinting' between vaccine adjuvants may mediate dissimilar effects on the quantity and quality of persisting adaptive responses. Specific combinations of immunoenhancers in the adjuvant systems increase antibody persistence and avidity maturation. Different adjuvants have varied effects on the duration and maturity of adaptive immune responses.

NPJ VACCINES (2021)

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Article Immunology

Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations

Konlavat Siriwattananon et al.

Summary: This study compares the immunogenicity of different commercially available adjuvants for plant-produced SARS-CoV-2 RBD-Fc vaccines and finds that all tested adjuvants induce high levels of immune responses, but mPLA-SM and poly(I:C) balance IgG1 and IgG2a (Th2/Th1) immune responses. The data reveals the adjuvants' role in enhancing the immune response and immune profiles, providing insights for the development of next-generation SARS-CoV-2 RBD-Fc subunit vaccines.

VACCINES (2021)

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Article Immunology

Plant-Expressed Receptor Binding Domain of the SARS-CoV-2 Spike Protein Elicits Humoral Immunity in Mice

Puna Maya Maharjan et al.

Summary: The current COVID-19 pandemic caused by SARS-CoV-2 has led to significant global impacts, with millions of deaths and economic losses. Rapid and large-scale vaccine production is crucial to combatting COVID-19. Utilizing plant species for inexpensive and efficient vaccine production can help improve global vaccine distribution to resource-limited countries. Through expressing the RBD of the SARS-CoV-2 spike protein in a glycoengineered tobacco plant, this study successfully generated a candidate subunit vaccine that induced humoral immunity in mice. These findings lay a strong foundation for further development of plant-expressed RBD antigens as effective, safe, and affordable SARS-CoV-2 vaccines, showcasing the potential of plant species in vaccine development.

VACCINES (2021)

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Review Immunology

Producing Vaccines against Enveloped Viruses in Plants: Making the Impossible, Difficult

Hadrien Peyret et al.

Summary: Plant molecular farming has grown in the past 30 years as a method for producing recombinant proteins, especially in the production of vaccine candidates. Despite challenges in expressing and purifying membrane-bound proteins for enveloped viruses, there have been significant successes with promising clinical trials for plant-produced vaccine candidates against such viruses.

VACCINES (2021)

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Review Microbiology

Potential for Developing Plant-Derived Candidate Vaccines and Biologics against Emerging Coronavirus Infections

Balamurugan Shanmugaraj et al.

Summary: The continuous evolution of the virus leads to occasional outbreaks, highlighting the importance of developing effective vaccines and therapeutic interventions.

PATHOGENS (2021)

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Review Biochemistry & Molecular Biology

Development and application of therapeutic antibodies against COVID-19

Lin Ning et al.

Summary: The global health crisis caused by the COVID-19 pandemic continues, with many therapeutic antibody treatments in development and authorized for emergency use by the FDA. Ongoing clinical trials worldwide have shown therapeutic antibody therapies to be a crucial part of COVID-19 treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Immunology

Current updates and research on plant-based vaccines for coronavirus disease 2019

Asqwin Uthaya Kumar et al.

Summary: COVID-19 has become a global pandemic, causing over a million deaths. Plant-based vaccines are gaining attention for their cost-effectiveness and efficient manufacturing process. Many companies worldwide are racing to develop an effective vaccine using the plant system amid challenges faced in the development process.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2021)

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Review Public, Environmental & Occupational Health

Epidemiology and pathobiology of SARS-CoV-2 (COVID-19) in comparison with SARS, MERS: An updated overview of current knowledge and future perspectives

Balasubramanian Ganesh et al.

Summary: SARS-CoV-2 is the causative agent of COVID-19, which originated in Wuhan, China, causing a global public health crisis. This review compares it with SARS and MERS, providing insights for future prevention, control, and treatment strategies.

CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH (2021)

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Review Immunology

Viral targets for vaccines against COVID-19

Lianpan Dai et al.

Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Public, Environmental & Occupational Health

Infection fatality rate of COVID-19 inferred from seroprevalence data

John P. A. Ioannidis

Summary: This study aimed to estimate the infection fatality rate of COVID-19 using seroprevalence data. The findings showed that the infection fatality rate varied significantly across different locations due to differences in population age structure, case mix of infected and deceased patients, and other factors. The inferred infection fatality rates were generally lower than earlier estimates made during the pandemic.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2021)

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Review Biotechnology & Applied Microbiology

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Tariq Khan et al.

Summary: Plant-based compounds show potential in fighting coronaviruses, with active ingredients like glycyrrhizin demonstrating promising results. These compounds act on the virus through various mechanisms, offering a potential alternative for COVID-19 treatment.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2021)

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Review Nanoscience & Nanotechnology

Plant molecular farming of virus-like nanoparticles as vaccines and reagents

Edward P. Rybicki

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Built-In Active Microneedle Patch with Enhanced Autonomous Drug Delivery

Miguel Angel Lopez-Ramirez et al.

ADVANCED MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Inhibition of SARS-CoV 3CL protease by flavonoids

Seri Jo et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

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Review Biotechnology & Applied Microbiology

Molecular farming - The slope of enlightenment

Rainer Fischer et al.

BIOTECHNOLOGY ADVANCES (2020)

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Review Integrative & Complementary Medicine

Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs

Luo Hui et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2020)

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Review Biochemical Research Methods

Innovation in plant-based transient protein expression for infectious disease prevention and preparedness

Frank Sainsbury

CURRENT OPINION IN BIOTECHNOLOGY (2020)

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Review Integrative & Complementary Medicine

Ethnobotanical Description and Biological Activities of Senna alata

Oluwole Solomon Oladeji et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Virology

The 2019-new coronavirus epidemic: Evidence for virus evolution

Domenico Benvenuto et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Letter Public, Environmental & Occupational Health

The reproductive number of COVID-19 is higher compared to SARS coronavirus

Ying Liu et al.

JOURNAL OF TRAVEL MEDICINE (2020)

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Article Virology

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

Yushun Wan et al.

JOURNAL OF VIROLOGY (2020)

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Article Medicine, General & Internal

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

Roujian Lu et al.

LANCET (2020)

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Article Medicine, General & Internal

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

Jasper Fuk-Woo Chan et al.

LANCET (2020)

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Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

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Review Chemistry, Medicinal

Antiviral activity of plants and their isolated bioactive compounds: An update

Marcella Denaro et al.

PHYTOTHERAPY RESEARCH (2020)

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Article Veterinary Sciences

Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments

Yashpal Singh Malik et al.

VETERINARY QUARTERLY (2020)

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Review Microbiology

Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development

Balamurugan Shanmugaraj et al.

PATHOGENS (2020)

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Review Biochemistry & Molecular Biology

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

Francesca Coperchini et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19

Valentino Clemente et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Editorial Material Medicine, Research & Experimental

SARS-CoV-2: a storm is raging

Savannah F. Pedersen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Virology

The basic reproduction number of SARS-CoV-2 in Wuhan is about to die out, how about the rest of the World?

Bootan Rahman et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

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Article Multidisciplinary Sciences

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

Yan Wu et al.

SCIENCE (2020)

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Article Virology

The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase

Jrhau Lung et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Review Plant Sciences

Potential Applications of Plant Biotechnology against SARS-CoV-2

Teresa Capell et al.

TRENDS IN PLANT SCIENCE (2020)

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Article Multidisciplinary Sciences

A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang et al.

NATURE COMMUNICATIONS (2020)

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Review Biotechnology & Applied Microbiology

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Emerging Zoonotic Respiratory Pathogen in Humans

Ashwini Malla et al.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Multidisciplinary Sciences

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Rui Shi et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Cross-neutralization ofSARS-CoV-2 by a human monoclonal SARS-CoV antibody

Dora Pinto et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

Kangpeng Xiao et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Waradon Sungnak et al.

NATURE MEDICINE (2020)

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Letter Medicine, General & Internal

Transmission of SARS-CoV-2 in Domestic Cats

Peter J. Halfmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Immunology

What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?

Sergio Rosales-Mendoza et al.

VACCINES (2020)

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Review Pharmacology & Pharmacy

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

Young Hun Chung et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Biochemistry & Molecular Biology

The recent challenges of highly contagious COVID-19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and immunotherapy

Ranjan K. Mohapatra et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2020)

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Article Biochemistry & Molecular Biology

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening

Olga Abian et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Immunology

The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?

Zaid Abassi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Plant Sciences

Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production

Balamurugan Shanmugaraj et al.

PLANTS-BASEL (2020)

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Review Biodiversity Conservation

Potential of DNA Intercalating Alkaloids and Other Plant Secondary Metabolites against SARS-CoV-2 Causing COVID-19

Michael Wink

DIVERSITY-BASEL (2020)

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Article Immunology

Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKKε

Lok-Yin Roy Wong et al.

JOURNAL OF IMMUNOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

p38 MAPK inhibition: A promising therapeutic approach for COVID-19

Joseph M. Grimes et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

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Article Chemistry, Physical

Does SARS-CoV-2 Bind to Human ACE2 More Strongly Than Does SARS-CoV?

Hoang Linh Nguyen et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2020)

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Letter Virology

The Nucleocapsid Protein of SARS-CoV-2: a Target for Vaccine Development

Noton K. Dutta et al.

JOURNAL OF VIROLOGY (2020)

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Article Medicine, General & Internal

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Pedro M. Folegatti et al.

LANCET (2020)

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Review Biochemistry & Molecular Biology

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

Ahmad Abu Turab Naqvi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

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Review Biochemistry & Molecular Biology

Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review

Li Ma et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

Seth J. Zost et al.

NATURE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Roles of flavonoids against coronavirus infection

Maria Russo et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Article Biology

Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay

Eleni Pitsillou et al.

COMPUTATIONAL BIOLOGY AND CHEMISTRY (2020)

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Article Pharmacology & Pharmacy

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Li Runfeng et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Integrative & Complementary Medicine

Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro

Minsu Jang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Review Virology

Natural product-derived phytochemicals as potential agents against coronaviruses: A review

Janice S. Mani et al.

VIRUS RESEARCH (2020)

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Article Urology & Nephrology

The SARS-CoV-2 Coronavirus and the COVID-19 Outbreak

Martin Alexander Lauxmann et al.

International Braz J Urol (2020)

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Review Nutrition & Dietetics

Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Ana H. A. Morais et al.

NUTRIENTS (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

E. J. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Pharmacology & Pharmacy

Drug repurposing approach to fight COVID-19

Thakur Uttam Singh et al.

PHARMACOLOGICAL REPORTS (2020)

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Review Pharmacology & Pharmacy

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

Christian Bailly et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Multidisciplinary Sciences

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

Alina Baum et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamiana

Kaewta Rattanapisit et al.

SCIENTIFIC REPORTS (2020)

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Review Plant Sciences

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Arif Jamal Siddiqui et al.

PLANTS-BASEL (2020)

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Review Cell Biology

Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19

Gustavo A. Arganaraz et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Multidisciplinary Sciences

High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents

Phongthon Kanjanasirirat et al.

SCIENTIFIC REPORTS (2020)

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Article Plant Sciences

Pilot Production of SARS-CoV-2 Related Proteins in Plants: A Proof of Concept for Rapid Repurposing of Indoor Farms Into Biomanufacturing Facilities

Borja Diego-Martin et al.

FRONTIERS IN PLANT SCIENCE (2020)

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Article Plant Sciences

Monoclonal Antibodies B38 and H4 Produced in Nicotiana benthamiana Neutralize SARS-CoV-2 in vitro

Balamurugan Shanmugaraj et al.

FRONTIERS IN PLANT SCIENCE (2020)

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Review Pharmacology & Pharmacy

Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury

Mohammad Bagher Majnooni et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Cell Biology

Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line

Christopher Stanly et al.

CELLS (2020)

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Review Cell Biology

Coronavirus vaccine development: from SARS and MERS to COVID-19

Yen-Der Li et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Article Biochemistry & Molecular Biology

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

Zezhong Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Medicine, Research & Experimental

Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?

Yusuf A. Haggag et al.

MEDICAL HYPOTHESES (2020)

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Article Immunology

Immunoinformatic Analysis of SARS-CoV-2 Nucleocapsid Protein and Identification of COVID-19 Vaccine Targets

Sergio C. Oliveira et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Integrative & Complementary Medicine

The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

Andrea D. Fuzimoto et al.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2020)

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Review Integrative & Complementary Medicine

Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective

Suraphan Panyod et al.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro

Seri Jo et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

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Letter Medicine, General & Internal

Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Veterinary Sciences

COVID-19: animals, veterinary and zoonotic links

Ruchi Tiwari et al.

VETERINARY QUARTERLY (2020)

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Review Oncology

2019 Novel Coronavirus (COVID-19) Outbreak: A Review of the Current Literature

Ahmet Riza Sahin et al.

EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY (2020)

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Article Integrative & Complementary Medicine

In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus

Deng-hai Zhang et al.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2020)

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Review Biodiversity Conservation

Therapeutic recombinant protein production in plants: Challenges and opportunities

Matthew J. B. Burnett et al.

PLANTS PEOPLE PLANET (2020)

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Review Medicine, Research & Experimental

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

Marco Tuccori et al.

MABS (2020)

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Article Infectious Diseases

SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study

Kore Schlottau et al.

LANCET MICROBE (2020)

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Review Immunology

A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses

Sin-Yee Fung et al.

EMERGING MICROBES & INFECTIONS (2020)

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Review Pharmacology & Pharmacy

Use of plant viruses and virus-like particles for the creation of novel vaccines

Ina Balke et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Biotechnology & Applied Microbiology

Comparison of microbial and transient expression (tobacco plants and plant-cell packs) for the production and purification of the anticancer mistletoe lectin viscumin

Benjamin B. Gengenbach et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

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Article Biochemistry & Molecular Biology

Transient expression of etanercept therapeutic protein in tobacco (Nicotiana tabacum L.)

Amir Bidarigh Fard et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Infectious Diseases

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

Kayvon Modjarrad et al.

LANCET INFECTIOUS DISEASES (2019)

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Article Multidisciplinary Sciences

Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate-Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults

Stephane Pillet et al.

PLOS ONE (2019)

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Article Biochemistry & Molecular Biology

Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors

Seri Jo et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

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Review Plant Sciences

Plant Viruses in Plant Molecular Pharming: Toward the Use of Enveloped Viruses

Ahmad Ibrahim et al.

FRONTIERS IN PLANT SCIENCE (2019)

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Article Multidisciplinary Sciences

Structural and In Vitro Functional Analyses of Novel Plant-Produced Anti-Human PD1 Antibody

Kaewta Rattanapisit et al.

SCIENTIFIC REPORTS (2019)

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Article Critical Care Medicine

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Paul A. Reyfman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells

Dong Eon Kim et al.

BIOMOLECULES (2019)

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Article Plant Sciences

Plant-Produced Anti-Enterovirus 71 (EV71) Monoclonal Antibody Efficiently Protects Mice Against EV71 Infection

Kaewta Rattanapisit et al.

PLANTS-BASEL (2019)

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Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Article Cell Biology

SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

Chong-Shan Shi et al.

CELL DEATH DISCOVERY (2019)

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Article Immunology

Transient expression of hemagglutinin antigen from canine influenza virus H3N2 in Nicotiana benthamiana and Lactuca sativa

Puna Maya Maharjan et al.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2019)

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Review Chemistry, Multidisciplinary

Plant molecular farming: production of metallic nanoparticles and therapeutic proteins using green factories

Reza Mohammadinejad et al.

GREEN CHEMISTRY (2019)

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Article Chemistry, Analytical

Confirmation of the antiviral properties of medicinal plants via chemical analysis, machine learning methods and antiviral tests: a methodological approach

Tomas Drevinskas et al.

ANALYTICAL METHODS (2018)

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Article Pharmacology & Pharmacy

Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

Christin Mueller et al.

ANTIVIRAL RESEARCH (2018)

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Article Virology

Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape

Lingshu Wang et al.

JOURNAL OF VIROLOGY (2018)

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Article Multidisciplinary Sciences

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity

Daniel K. W. Chu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Virology

Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3

Hui Hui Wong et al.

VIROLOGY (2018)

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Review Plant Sciences

The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons

Julia Bally et al.

ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 56 (2018)

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Article Cell Biology

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

Yuan Yue et al.

CELL DEATH & DISEASE (2018)

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Review Immunology

The emerging role of ADAM metalloproteinases in immunity

Bart N. Lambrecht et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Advanced Plant-Based Glycan Engineering

Laura Montero-Morales et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Review Immunology

Plant-based vaccines against respiratory diseases: current status and future prospects

Veronica A. Marquez-Escobar et al.

EXPERT REVIEW OF VACCINES (2017)

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Article Virology

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

Wanbo Tai et al.

JOURNAL OF VIROLOGY (2017)

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Article Chemistry, Applied

Essential oil composition, total phenolic, flavonoid contents, and antioxidant activity of Thymus species collected from different regions of Iran

Behnaz Tohidi et al.

FOOD CHEMISTRY (2017)

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Article Virology

Influenza and rhinovirus viral load and disease severity in upper respiratory tract infections

Andrea Granados et al.

JOURNAL OF CLINICAL VIROLOGY (2017)

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Article Biochemistry & Molecular Biology

Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

Ji-Young Park et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

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Article Biotechnology & Applied Microbiology

Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection

Yufei Wang et al.

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