期刊
VACCINES
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/vaccines10101708
关键词
SARS-CoV-2; vaccination; booster dose; RBD antibody; neutralizing antibody; spike antibody
资金
- Tehran University of Medical Sciences
This study examined the necessity of booster doses of COVID-19 vaccination. The results showed that individuals who received three doses of the vaccine had higher levels of antibodies, indicating that a booster dose enhances the antibody response.
Background: There is debate on the necessity of booster doses of COVID-19 vaccination, especially in countries with limited resources. Methods: This cross-sectional study was conducted in a referral laboratory in Tehran, Iran. The level of COVID-19 antibodies was measured and compared between individuals regarding the number of COVID-19 vaccine shots. Results: In this study, 176 individuals with a mean age of 36.3 (+/- 11.7) years participated. A total of 112 individuals received two doses of the COVID-19 vaccine, and 64 individuals received three doses. Level of all antibodies was higher in those who received three doses than in those who received two doses of the COVID-19 vaccine. Considering the SARS-CoV-2 Spike IgG, the difference was not statistically significant but for the SARS-CoV-2 RBD IgG and SARS-CoV-2 NAB the difference was statistically significant. Regarding to the background variables, receiving influenza vaccine in the past year, history of autoimmune diseases and past medical history of chicken pox showed a significant association with the number of vaccine doses received. Their effects on the outcome variables assessed with multivariate logistic regression analysis. Conclusion: The results of our study show that a booster dose of the COVID-19 vaccine enhances the antibody response.
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