4.7 Article

Acetylsalicylic Acid and Salicylic Acid Inhibit SARS-CoV-2 Replication in Precision-Cut Lung Slices

期刊

VACCINES
卷 10, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/vaccines10101619

关键词

acetylsalicylic acid; salicylic acid; antiviral activity; aspirin; SARS-CoV-2; precision-cut lung slices

资金

  1. Bayer Vital GmbH
  2. Open Access Publication Fund of the University of Wuerzburg

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The study found that aspirin and its metabolite salicylic acid can inhibit the replication of SARS-CoV-2 virus in cells. Although these compounds do not interfere with viral entry, they can inhibit post-entry pathways, thereby reducing the expression of viral RNA.
Aspirin, with its active compound acetylsalicylic acid (ASA), shows antiviral activity against rhino- and influenza viruses at high concentrations. We sought to investigate whether ASA and its metabolite salicylic acid (SA) inhibit SARS-CoV-2 since it might use similar pathways to influenza viruses. The compound-treated cells were infected with SARS-CoV-2. Viral replication was analysed by RTqPCR. The compounds suppressed SARS-CoV-2 replication in cell culture cells and a patient-near replication system using human precision-cut lung slices by two orders of magnitude. While the compounds did not interfere with viral entry, it led to lower viral RNA expression after 24 h, indicating that post-entry pathways were inhibited by the compounds.

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