A Systematic Review of Reported Cases of Immune Thrombocytopenia after COVID-19 Vaccination

Letter Hematology

Vincristine therapy for severe and refractory immune thrombocytopenia following COVID-19 vaccination

Kei Saito et al.

ANNALS OF HEMATOLOGY (2022)

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Letter Hematology

Immune Thrombocytopenia (ITP): Relapse Versus de novo After COVID-19 Vaccination

Mona Al-Ahmad et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2022)

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Letter Hematology

Acute immune thrombocytopenia following SARS-CoV-2 vaccination in chronic ITP patients and a healthy individual

Asuka Ogai et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2022)

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Article Hematology

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

Daisuke Hidaka et al.

Summary: This case study describes a 53-year-old woman who developed new-onset Evans syndrome associated with SLE following BNT162b2 mRNA COVID-19 vaccination. Blood tests showed hemolytic anemia and thrombocytopenia, with successful treatment using prednisolone. The case suggests a potential link between mRNA COVID-19 vaccination and autoimmune disorders, highlighting the importance of weighing the benefits and risks of vaccination for each individual.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2022)

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Letter Hematology

Detection of anti-GPIba autoantibodies in a case of immune thrombocytopenia following COVID-19 vaccination

Takayuki Nakamura et al.

THROMBOSIS RESEARCH (2022)

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Article Hematology

ChAdOx1 nCoV-19 vaccine-associated thrombocytopenia: three cases of immune thrombocytopenia after 107 720 doses of ChAdOx1 vaccination in Thailand

Noppacharn Uaprasert et al.

Summary: We reported three cases of immune thrombocytopenia (ITP) that developed within 6 weeks after ChAdOx1 nCoV-19 vaccination. The presence of antiplatelet factor 4 antibodies was ruled out in all cases, making vaccine-induced immune thrombotic thrombocytopenia very unlikely. The clinical presentations, severity, and outcomes of these cases varied. The estimated risk of ITP after ChAdOx1 vaccination was determined to be one per 36,000 doses, similar to the risk after measles-mumps-rubella immunization, raising concerns about an increased risk of ITP.

BLOOD COAGULATION & FIBRINOLYSIS (2022)

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Article Emergency Medicine

Severe immune thrombocytopenia following COVID-19 vaccination (Moderna) and immune checkpoint inhibitor

Kah-Meng Chong et al.

Summary: We report a rare case of severe immune thrombocytopenia in an Asian woman following the administration of the Moderna COVID-19 vaccine. This highlights a potential adverse effect of mRNA-based vaccines in cancer patients receiving immune checkpoint inhibitors.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2022)

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Letter Medicine, General & Internal

Immune thrombocytopenia following COVID-19 mRNA vaccine: casuality or causality?

Federico Pasin et al.

INTERNAL AND EMERGENCY MEDICINE (2022)

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Review Medicine, General & Internal

Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review

Takuto Shonai et al.

Summary: This study reported two cases of vaccine-induced immune thrombocytopenia (ITP) following COVID-19 vaccination, including one male and one female patient. Both patients developed thrombocytopenia after vaccination but improved rapidly with treatment.

INTERNAL MEDICINE (2022)

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Article Infectious Diseases

Safety of mRNA vaccines administered during the initial 6 months of the US COVID-19 vaccination programme: an observational study of reports to the Vaccine Adverse Event Reporting System and v-safe

Hannah G. Rosenblum et al.

Summary: The surveillance data from the first 6 months of the US COVID-19 vaccination program, involving over 298 million doses of mRNA vaccines, demonstrate that the majority of reported adverse events were mild and of short duration.

LANCET INFECTIOUS DISEASES (2022)

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Article Cell Biology

Successful mRNA SARS-Cov-2 vaccine rechallenge after a first episode of immune thrombocytopenic purpura

Mathilde Chanut et al.

Summary: This article presents a case of a 73-year-old woman who developed de novo immune thrombocytopenia purpura (ITP) after the first dose of SARS-Cov-2 mRNA vaccine (Moderna vaccine), but successfully underwent a rechallenge with SARS-Cov-2 mRNA vaccine (Pfizer vaccine) a few months later.

PLATELETS (2022)

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Letter Medicine, General & Internal

Acute immune thrombocytopenic purpura post first dose of COVID-19 vaccination

Jessica Sue Yi Wong et al.

POSTGRADUATE MEDICAL JOURNAL (2022)

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Review Hematology

Thrombotic thrombocytopenic purpura (TTP) after COVID-19 vaccination: A systematic review of reported cases

Prachi Saluja et al.

Summary: With the advent of COVID-19 vaccines, there have been reports of autoimmune hematological complications such as TTP occurring after vaccination. This study reviewed existing cases of TTP after COVID-19 vaccination and found that it is more common after BNT162b2 and mRNA-1273 vaccines. Treatment for immune TTP typically involves plasma exchange and steroids. An in-depth anamnesis before vaccination is important, and the possibility of TTP should be considered when evaluating post-vaccine thrombocytopenia.

THROMBOSIS RESEARCH (2022)

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Article Medicine, General & Internal

BNT162b2 COVID-19 Vaccine Induced Immune Thrombocytopenic Purpura

A. K. Ghosh et al.

Summary: This article presents a case of a patient who developed severe immune thrombocytopenic purpura (ITP) with a platelet count of 0 after receiving the second dose of the Pfizer BioNTech COVID-19 vaccine. Similar cases have been reported after other vaccinations and viral infections.

CASE REPORTS IN MEDICINE (2022)

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Article Medicine, General & Internal

Vaccination-associated immune thrombocytopenia possibly due to ChAdOx1 nCoV-19 (Covishield) coronavirus vaccine

Prakash Sivaramakrishnan et al.

Summary: Immune thrombocytopenia (ITP) is a hemorrhagic disorder caused by immune-mediated destruction, impaired production, or increased splenic sequestration of platelets. Vaccines against various infectious agents can cause vaccine-associated ITP (VITP), including measles-mumps-rubella, Haemophilus influenzae, pneumococcus, hepatitis B virus, and human papilloma virus. Cases of VITP post SARS-CoV-2 vaccination have also been reported. Treatment options include steroids, intravenous immunoglobulins, and other agents.

BMJ CASE REPORTS (2022)

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Article Hematology

Immune Thrombocytopenia following COVID-19 Vaccine

Sonal Prasad et al.

Summary: Common side effects of COVID-19 vaccines include fever, chills, headache, etc., but rare adverse reactions such as induced thrombocytopenia can also occur.

CASE REPORTS IN HEMATOLOGY (2022)

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Article Oncology

COVID-19 vaccination associated severe immune thrombocytopenia

Syed Raza Ali Shah et al.

Summary: This study reports three cases of severe immune thrombocytopenia (ITP) following COVID-19 vaccination and their clinical course. Treatment with oral immunoglobulin and dexamethasone resulted in improvement in platelet counts for all cases, indicating a potential effective management approach for vaccine-induced ITP.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2021)

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Article Hematology

Oxford-AstraZeneca Coronavirus Disease-2019 Vaccine-Induced Immune Thrombocytopenia on Day Two

Azhar Kareem Razzaq et al.

Summary: Vaccines have significantly affected human life expectancy, but in some cases, they may trigger immune-related diseases. ITP presents with varying clinical manifestations depending on severity and is typically treated with immunosuppression. Close monitoring is essential for patients with a history of thrombocytopenia when receiving vaccines, as the immune modulation process of the vaccine can exacerbate preexisting conditions.

CASE REPORTS IN HEMATOLOGY (2021)

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Article Medicine, General & Internal

A Case of Immune Thrombocytopenia After BNT162b2 mRNA COVID-19 Vaccination

Eleanor R. King et al.

Summary: This case study presents a rare complication of immune thrombocytopenic purpura (ITP) following the BNT162b2 mRNA COVID-19 vaccination, highlighting the importance of early detection and management to prevent life-threatening bleeding.

AMERICAN JOURNAL OF CASE REPORTS (2021)

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Article Medicine, General & Internal

Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine

Adam Hines et al.

Summary: A 26-year-old woman developed immune thrombocytopenic purpura and transaminitis 2 weeks after receiving the Moderna mRNA-1273 vaccine. Treatment with steroids and immunoglobulin led to improvement in platelet count and liver enzymes. The temporal relationship suggests the vaccine as a potential inciting factor.

BMJ CASE REPORTS (2021)

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Review Emergency Medicine

Thrombosis with thrombocytopenia syndrome associated with COVID-19 vaccines

Brit Long et al.

Summary: This review summarized the background, evaluation, and management of vaccine-induced immune thrombotic thrombocytopenia (TTS). TTS is mainly associated with the Oxford-AstraZeneca and Johnson & Johnson vaccines, characterized by thrombosis and thrombocytopenia, with a low overall incidence.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Letter Hematology

Immune thrombocytopenia in a 22-year-old post Covid-19 vaccine

Omar Tarawneh et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Letter Hematology

Severe immune thrombocytopenia after COVID-19 vaccination: Report of four cases and review of the literature

Angelo Gardellini et al.

BLOOD CELLS MOLECULES AND DISEASES (2021)

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Letter Hematology

Familial thrombocytopenia flare-up following the first dose of mRNA-1273 Covid-19 vaccine

Sudhamshi Toom et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Editorial Material Hematology

Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination

Eun-Ju Lee et al.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

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Letter Emergency Medicine

Idiopathic Thrombocytopenic Purpura and the Moderna Covid-19 Vaccine

Jeffrey A. Julian et al.

ANNALS OF EMERGENCY MEDICINE (2021)

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Article Immunology

Immune thrombocytopenia following immunisation with Vaxzevria ChadOx1-S (AstraZeneca) vaccine, Victoria, Australia

Sally F. Gordon et al.

Summary: The study found a significantly higher incidence of ITP following AstraZeneca vaccination than expected, while the incidence following Pfizer-BioNTech vaccination was consistent with expectations. Most cases required hospitalization or medical treatment, with 11 cases needing intervention with multiple therapy modalities.

VACCINE (2021)

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Letter Hematology

Immune thrombocytopenic purpura after SARS-CoV-2 vaccine

Marcello Candelli et al.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Immunology

Immune Thrombocytopenia Induced by the Chimpanzee Adenovirus-Vectored Vaccine against SARS-CoV-2 Infection

Po-Wei Liao et al.

Summary: A case of immune thrombocytopenia induced by chimpanzee adenovirus-vectored vaccine highlighted the rare side effects that can be caused by this type of vaccine, including immune thrombotic thrombocytopenia. This case demonstrated the potential for immune thrombocytopenia without thrombosis, emphasizing the importance of vigilance as global vaccine administrations against coronavirus disease increase.

VACCINES (2021)

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Article Immunology

Thrombocytopenia including immune thrombocytopenia after receipt of mRNA COVID-19 vaccines reported to the Vaccine Adverse Event Reporting System (VAERS)

Kerry J. Welsh et al.

Summary: This study analyzed VAERS reports of thrombocytopenia after vaccination with Pfizer-BioNTech COVID-19 Vaccine or Moderna COVID-19 Vaccine. The results showed a reporting rate of 0.80 per million doses for both vaccines, and the observed number of all thrombocytopenia cases following administration of mRNA COVID-19 vaccines is not greater than the number of ITP cases expected. Conclusion: The number of thrombocytopenia cases reported to VAERS does not suggest a safety concern attributable to mRNA COVID-19 vaccines at this time.

VACCINE (2021)

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Article Pharmacology & Pharmacy

Immune-Mediated Thrombocytopenia Associated With Ad26.COV2.S (Janssen; Johnson & Johnson) Vaccine

Sanchari Banerjee et al.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

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Article Hematology

Immune thrombocytopenic purpura after vaccination with COVID-19 vaccine (ChAdOx1 nCov-19)

Finn-Ole Paulsen et al.

BLOOD (2021)

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Letter Hematology

Correspondence in reference to the previously published Epub manuscript: immune thrombocytopenic purpura after SARS-CoV-2 vaccine

Quentin Scanvion et al.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Hematology

Exacerbation of immune thrombocytopenia following COVID-19 vaccination

David J. Kuter

Summary: A study found that COVID-19 vaccination may have varying effects on ITP patients, with some experiencing significant platelet count drops and new bleeding symptoms post-vaccination, but platelets recovered after rescue treatment.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Obstetrics & Gynecology

Newly diagnosed immune thrombocytopenia in a pregnant patient after coronavirus disease 2019 vaccination

Carrie Bennett et al.

Summary: A case report of immune thrombocytopenia in the first trimester following COVID-19 vaccination was presented, with successful treatment outcome. The authors advocate for including pregnant women in COVID-19 vaccine trials and highlight the importance of post-vaccination surveillance in this population.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2021)

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Letter Dermatology

Immune thrombocytopenic purpura associated with COVID-19 Pfizer-BioNTech BNT16B2b2 mRNA vaccine

P. K. Krajewski et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

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Article Biochemistry & Molecular Biology

First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland

C. R. Simpson et al.

Summary: Analysis of data from the EAVE II cohort in Scotland has shown that a first dose of the ChAdOx1 nCoV-19 vaccine may be associated with increased risks of idiopathic thrombocytopenic purpura, arterial thromboembolic events, and hemorrhagic events. However, there were no positive associations found between the BNT162b2 vaccine and these adverse events.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study

Julia Hippisley-Cox et al.

Summary: The study found increased risks of haematological and vascular events leading to hospital admission or death within short time intervals after first doses of the ChAdOx1 nCoV-19 and BNT162b2 mRNA vaccines. The risks of these events were higher and more prolonged after SARS-CoV-2 infection compared to vaccination in the same population.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Immunology

Acute Immune Thrombocytopenia (ITP) Following COVID-19 Vaccination in a Patient With Previously Stable ITP

Muzamil Jawed et al.

Summary: The COVID-19 vaccine may lead to immune thrombocytopenia (ITP), but the mechanisms behind this association remain unclear and require further research.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran - a clinical case and global pharmacovigilance data

Raphael Battegay et al.

Summary: This case report describes a 77-year-old man who developed ITP after receiving the first dose of the COVID-19 vaccine, but had a stable platelet count after treatment and proceeding with the second dose. This is the first reported instance of a second vaccine dose being administered to a patient with presumed secondary ITP. Global pharmacovigilance data on ITP occurrence post-tozinameran vaccination are also included in the report.

SWISS MEDICAL WEEKLY (2021)

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Article Infectious Diseases

Immune thrombocytopenia relapse post covid-19 vaccine in young male patient

Hana Qasim et al.

Summary: ITP is an autoimmune disorder where platelet destruction is caused by antibodies, and cases of relapse post COVID-19 vaccination have been reported. Treatment involves the use of immunoglobulins and steroids.

IDCASES (2021)

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Article Medicine, General & Internal

A Case Report of Immune Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

Gyungah Kim et al.

Summary: This case report describes a patient who developed ITP after receiving the AstraZeneca vaccine, with symptoms appearing 3 days after vaccination. Prompt clinical suspicion and appropriate treatment are essential for vaccine-related ITP.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Article Infectious Diseases

Immune thrombocytopenia associated with Pfizer-BioNTech's BNT162b2 mRNA COVID-19 vaccine

Hiroaki Akiyama et al.

Summary: This study reported a case of a 20-year-old woman developing ITP after receiving Pfizer-BioNTech's BNT162b2 vaccine. Treatment with oral steroids led to rapid improvement, underscoring the importance of timely diagnosis and treatment for rare adverse events like ITP following vaccination.

IDCASES (2021)

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Article Medicine, General & Internal

Immune Thrombocytopenic Purpura Following Pfizer-BioNTech COVID-19 Vaccine in an Elderly Female

Ranjit B. Jasaraj et al.

Summary: Mass vaccination campaigns are being conducted globally to combat the ongoing COVID-19 pandemic, with reports emerging of immune thrombocytopenic purpura occurring after vaccination. A case of immune thrombocytopenia following Pfizer-BioNTech vaccination in a 67-year-old female was reported, with treatment initially resistant to high-dose steroids, IVIG, and rituximab but eventually responding to a thrombopoietin-stimulating agent.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Letter Pharmacology & Pharmacy

Immune Thrombocytopenic Purpura Associated With Pfizer-BioNTech COVID-19 Vaccine Refractory to Conventional Treatment

Ghulam Ghous et al.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

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Article Medicine, General & Internal

Newly Diagnosed Idiopathic Thrombocytopenia Post COVID-19 Vaccine Administration

Precious O. Idogun et al.

Summary: The development of immune thrombocytopenia (ITP) following COVID-19 vaccine administration has been reported in some individuals, with uncertainties regarding complete remission of the disease due to its relapsing nature. This phenomenon requires further attention and research.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Medicine, General & Internal

Secondary immune thrombocytopenia supposedly attributable to COVID-19 vaccination

Omar Fueyo-Rodriguez et al.

Summary: There have been reports of ITP as a complication of SARS-CoV-2 infection, but as of now, there have been no reports on the association of the COVID-19 vaccine with thrombocytopenia. Here we present a case of secondary ITP in a patient who recently received the mRNA COVID-19 vaccine BNT162b2 (Pfizer-BioNTech).

BMJ CASE REPORTS (2021)

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Article Medicine, General & Internal

Purpuric Rash and Thrombocytopenia After the mRNA-1273 (Moderna) COVID-19 Vaccine

Srikrishna Malayala et al.

Summary: This case report describes a 60-year-old male patient who developed purpuric rash and thrombocytopenia after receiving the mRNA-1273 vaccine. He had underlying health issues such as smoking history, liver cirrhosis, chronic kidney disease, hypertension, and heart failure. The symptoms are believed to be side effects of the vaccine based on limited literature and the absence of other underlying causes.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

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Article Hematology

Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine

Jackie M. Helms et al.

Summary: The rollout of the SARS-CoV-2 vaccine has led to reports of severe thrombocytopenia, with one case described in this article where aggressive treatment eventually led to platelet count normalization. Vigilance to post-vaccination severe thrombocytopenia is warranted to ensure the safe continuation of global vaccination efforts.

JOURNAL OF BLOOD MEDICINE (2021)

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Article Hematology