☆ 4.7 Review

Therapeutic application of hydrogels for bone-related diseases

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Orthopedics

Osteoarthritis year in review 2021: epidemiology & therapy

J. G. Quicke et al.

Summary: This article reviews research themes and individual studies in the clinical osteoarthritis field, including COVID-19, disease burden, occupational risk, prediction models, etc. Important findings include the impact of non-steroidal anti-inflammatory drugs on COVID-19 related deaths, the increasing incidence rate of OA, and the relationship between cartilage thickness loss and pain.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Review Oncology

Recent Advances in Nanoplatforms for the Treatment of Osteosarcoma

Kunzhe Wu et al.

Summary: Osteosarcoma is the most common primary bone tumor in children and young people. Traditional treatment methods have limitations, and nanometer-sized platform-based chemotherapeutic delivery is a promising alternative therapy that offers accurate drug delivery and bone defect repair. This review provides a brief summary of various nanoplatforms, discusses their shortcomings and proposed solutions, and explores the application prospects of nanoplatforms in osteosarcoma treatment.

FRONTIERS IN ONCOLOGY (2022)

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Article Engineering, Biomedical

Novel magnetic silk fibroin scaffolds with delayed degradation for potential long-distance vascular repair

Xin Liu et al.

Summary: A novel magnetic SF scaffold (MSFCs) was prepared by an improved infiltration method, exhibiting better crystallinity, magnetocaloric properties, and mechanical strength compared to SF scaffold (SFC). The delayed degradation of MSFCs was attributed to the formation of hydrogen bonds and complexing to tyrosine to inhibit hydrolase by internal iron atoms. Doping MNPs showed a beneficial effect on beta-crystallization of protein and did not affect the function of macrophages.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia

Yuxiang Sun et al.

Summary: The SOD-like activity of CeO2 nanoparticles is inactivated by high oxidative stress. However, Au@Ce NPs, assembled by Au NPs and Ce NPs, exhibited high-performance SOD mimetic enzyme activity even under oxidative conditions. The enhanced localized surface plasmon resonance of nano-Au supported Ce NPs enables the maintenance of Ce3+/Ce4+ stability and SOD-like activity. Au@Ce NPs effectively scavenged ROS in AML cells, thereby inhibiting cell proliferation and cell cycle progression.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

Xu Xue et al.

Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.

BIOACTIVE MATERIALS (2022)

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Review Engineering, Biomedical

Flexible polymeric patch based nanotherapeutics against non-cancer therapy

Houjuan Zhu et al.

Summary: Flexible polymeric patches have wide applications in biomedicine due to their biological and tunable features. The combination of nanomaterials with polymeric patches can improve curative efficacy and reduce systemic toxicity. This review briefly presents the classification and advantages of flexible polymeric patches integrated with nanomaterials, and systematically reviews their applications in non-cancerous diseases. The limitations, challenges, and future perspectives of these biomedical therapeutic devices are also discussed.

BIOACTIVE MATERIALS (2022)

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Article Polymer Science

Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels

Qiuyi Chen et al.

Summary: In this study, biomimetic cartilage-lubricating hydrogels were synthesized to achieve lower friction and wear through boundary lubrication and fluid film lubrication mechanisms, offering a potential new solution for the treatment of early osteoarthritis.

GELS (2022)

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Review Biotechnology & Applied Microbiology

Recent Developments and Current Applications of Hydrogels in Osteoarthritis

Tianhao Zhao et al.

Summary: Hydrogels have great potential in the treatment of osteoarthritis, as they can improve drug delivery, facilitate cell growth and migration, and promote bone regeneration.

BIOENGINEERING-BASEL (2022)

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Article Polymer Science

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Ana C. Branco et al.

Summary: New PVA-based hydrogels were developed with improved tribomechanical properties and controlled drug release of diclofenac through PAA addition, PEG immersion, and annealing treatment. These hydrogels show promising potential for cartilage replacement and local drug delivery systems by enhancing their mechanical performance while ensuring controlled drug release.

GELS (2022)

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Article Chemistry, Multidisciplinary

Hydration Lubrication in Biomedical Applications: From Cartilage to Hydrogels

Weifeng Lin et al.

Summary: In the course of evolution, nature has achieved remarkably lubricated surfaces, with healthy articular cartilage in the major joints being the prime example. The precise mechanism of low friction between such sliding cartilage tissues, which is closely related to osteoarthritis, has been studied for nearly a century but is still not fully understood. Hydration lubrication has emerged as a new paradigm for boundary lubrication in aqueous media, and understanding cartilage lubrication could lead to better treatments for OA.

ACCOUNTS OF MATERIALS RESEARCH (2022)

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Review Rheumatology

Pharmacological Management of Osteoarthritis With a Focus on Symptomatic Slow-Acting Drugs Recommendations From Leading Russian Experts

Lila A. M. Alexander et al.

Summary: This article presents an updated stepwise algorithm for the pharmacological management of osteoarthritis, suggesting various treatment options including symptomatic slow-acting drugs, oral NSAIDs, and intra-articular therapies. Total joint replacement is recommended for patients with severe symptoms. Further discussions are needed to harmonize recommendations in knee OA management.

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2021)

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Article Nanoscience & Nanotechnology

3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis

Ce Zhu et al.

Summary: The study developed the first 3D-printed PEEK-based bone scaffold with multiple functions for treating challenging bone diseases. The scaffold, coated with a drug-laden hydroxyapatite layer, utilized graphene nanosheets for on-demand photothermal conversion under laser irradiation. The presence of antibiotics and anti-cancer drugs enhanced treatment efficacy against drug-resistant bacteria and osteosarcoma cells.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis

Xin Yan et al.

Summary: The DNA supramolecular hydrogel has been shown to provide excellent protection for MSCs against shear forces, promoting quality cartilage formation, reducing osteophyte formation, and normalizing subchondral bone under high friction conditions of OA. This material has potential as a promising cell delivery system for various MSCs therapies.

ADVANCED MATERIALS (2021)

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Review Engineering, Biomedical

Polymeric hydrogels as a vitreous replacement strategy in the eye

Qianyu Lin et al.

Summary: This article discusses the common use and characteristics of vitreous endo-tamponades in the treatment of retinal conditions, and suggests the potential of polymeric hydrogels as an ideal alternative due to their advantageous properties. Various design strategies have been employed to develop polymeric hydrogel-based vitreous endo-tamponades, aiming to combine therapeutic effectiveness with patient comfort.

BIOMATERIALS (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Multidisciplinary

Ultrasound augmenting injectable chemotaxis hydrogel for articular cartilage repair in osteoarthritis

Hui Liu et al.

Summary: Tissue engineering technology has become a hot topic in articular cartilage repair to alleviate osteoarthritis, with hydrogel being a commonly used scaffold material that provides a good extracellular matrix microenvironment for stem cells. However, the low homing rate of stem cells limits their role in cartilage regeneration. A novel injectable chemotaxis hydrogel that combines chitosan-based hydrogel with SDF-1 alpha-loaded nanodroplets has been designed to promote stem cell homing and cartilage repair in OA, showing promising potential for future treatment strategies.

CHINESE CHEMICAL LETTERS (2021)

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Review Biophysics

A review of hydrogel systems based on poly(N-isopropyl acrylamide) for use in the engineering of bone tissues

Saeid Shabestari Khiabani et al.

Summary: This review discusses the potential of injectable N-isopropyl acrylamide-based hydrogels in bone fracture repair, for delivering scaffolds, cells, and growth factors.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Pharmacology & Pharmacy

Biological drug and drug delivery-mediated immunotherapy

Qingqing Xiao et al.

Summary: The onset and progression of inflammatory diseases such as cancer, vascular inflammation, and autoimmune diseases are closely linked to the immune system. Biologics-based immunotherapy plays a critical role in combating these diseases, while drug delivery strategies are potent in promoting their delivery.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Engineering, Biomedical

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

Chong Wang et al.

Summary: 3D printing is increasingly used to create advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths for improved bone regeneration. Customized scaffolds were produced using cryogenic 3D printing of beta-tricalcium phosphate and osteogenic peptide inks, and coated with angiogenic peptide hydrogel to enhance vascularization. The scaffolds had a hierarchically porous structure similar to human cancellous bone and showed high viability for both endothelial cells and mesenchymal stem cells. Improved in vitro migration and angiogenesis were observed for scaffolds with angiogenic peptide, while enhanced osteogenic differentiation was seen in scaffolds containing osteogenic peptide. In vivo, scaffolds with both peptides showed increased angiogenesis and new bone formation.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Mechanical

A bionic PEEK composite structure with negatively charged surface adsorbing molecular brushes possessing improved biotribological properties for artificial joints

Yuntong Liu et al.

Summary: A PEEK-hydrogel composite structure was designed and fabricated to improve the contact mode of artificial joints, with a significantly reduced friction coefficient achieved through the adsorption of cationic molecules via electrostatic interaction. This novel approach provides a new route for developing the friction surface of artificial joints with advanced performance.

TRIBOLOGY INTERNATIONAL (2021)

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Review Engineering, Biomedical

Advancing application of mesenchymal stem cell-based bone tissue regeneration

Fengqing Shang et al.

Summary: The utilization of regenerative biomaterials for bone repair requires not only efficacy and safety, but also cost-effectiveness and convenience. Understanding the roles of regenerative biomaterials and mesenchymal stem cells in new bone formation can potentially open new opportunities in the field of bone regeneration.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Recent Progress in Cartilage Lubrication

Weifeng Lin et al.

Summary: Healthy articular cartilage has very low friction coefficients, which help reduce wear and tear and cartilage degradation, maintaining the balance of chondrocyte functions. Investigating the origins of low friction in articular cartilage is crucial for alleviating disease symptoms and slowing or reversing the degradation process. Recent studies have focused on the mechanisms of joint lubrication and the development of natural and bio-inspired lubricants.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Alina Kirillova et al.

Summary: The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.

CHEMICAL REVIEWS (2021)

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Article Engineering, Biomedical

Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis

Renjian Xie et al.

Summary: Using brush-like biopolymers to mimic the lubrication properties of natural cartilage-binding complexes can enhance cartilage regeneration in a rat model of early osteoarthritis. The biomimetic nanofibers with added lubricin-like and lipid-like compounds show a high affinity for cartilage proteins and effectively lubricate damaged cartilage, leading to cartilage regeneration and the abrogation of osteoarthritis within 8 weeks. This approach may offer a translational strategy for the treatment of early osteoarthritis.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Engineering, Biomedical

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites: In vitro and in vivo studies

Zechuan Zhang et al.

Summary: The novel biodegradable metal system of ZnLiCa ternary alloys showed comparable tensile strength to pure Ti and great potential for bone defect regeneration. The alloys demonstrated good biocompatibility and osteogenesis-promoting effects.

BIOACTIVE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Advances in targeted therapy for osteosarcoma based on molecular classification

Yingqian Chen et al.

Summary: Osteosarcoma, a highly malignant tumor with widespread genetic abnormalities, can be stratified into molecular subtypes for targeted therapy. Molecular classification based on genetic characteristics helps in achieving better therapeutic responses and moving towards personalized medicine.

PHARMACOLOGICAL RESEARCH (2021)

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Article Engineering, Biomedical

Zn0.8Li0.1Sr-a biodegradable metal with high mechanical strength comparable to pure Ti for the treatment of osteoporotic bone fractures: In vitro and in vivo studies

Zechuan Zhang et al.

Summary: The study presents the first in vivo investigation of a Zn-based biodegradable metal for treating osteoporotic bone fractures, demonstrating excellent mechanical properties and superior osteogenesis-inducing and osteoporotic-bone-fracture-treating effects compared to pure Ti.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Structurally Dynamic Hydrogels for Biomedical Applications: Pursuing a Fine Balance between Macroscopic Stability and Microscopic Dynamics

Kunyu Zhang et al.

Summary: Hydrogels are gaining increasing attention in biomedical studies due to their unique chemical and physical properties. Dynamic hydrogels, which can better mimic the functions of natural extracellular matrix, have shown promise in applications such as regenerative medicine and drug delivery. Recent research has focused on the fabrication strategies and unique properties of dynamic hydrogels, as well as discussing challenges and emerging trends in their development and application.

CHEMICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Advanced Hydrogels as Exosome Delivery Systems for Osteogenic Differentiation of MSCs: Application in Bone Regeneration

Elham Pishavar et al.

Summary: Hydrogels, when combined with exosomes, contribute to improving methodologies in bone tissue engineering and play a crucial role in tissue repair and remodeling.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Engineering, Biomedical

Hydrogels in the treatment of rheumatoid arthritis: drug delivery systems and artificial matrices for dynamic in vitro models

Isabel Maria Oliveira et al.

Summary: Rheumatoid arthritis is an autoimmune and chronic inflammatory disorder that affects synovial joints, with traditional drug treatments presenting limited effectiveness and severe side effects. Hydrogels offer a promising drug delivery system to reduce side effects and maximize therapeutic effects, while also serving as a tool for mimicking physiological environments and in vitro cartilage models.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2021)

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Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Peritumoral Microgel Reservoir for Long-Term Light-Controlled Triple-Synergistic Treatment of Osteosarcoma with Single Ultra-Low Dose

Jiaqi Yan et al.

Summary: A nano-composite @ microgel system was developed to improve drug utilization and reduce systemic adverse effects, showing long-term therapeutic effects in osteosarcoma treatment. This system demonstrates good injectability and modulated drug release capabilities.

SMALL (2021)

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Review Pharmacology & Pharmacy

Hydrogels and Their Role in Bone Tissue Engineering: An Overview

Jaisanghar Nallusamy et al.

Summary: The article discusses the increasing incidence of bone damage and the importance of hydrogel in bone tissue engineering, highlighting the need for new technologies and treatments for a normal and healthy life.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2021)

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Review Engineering, Biomedical

Recent Strategies for Strengthening and Stiffening Tough Hydrogels

Donghwan Ji et al.

Summary: Hydrogels are important components of the human body, and there is a need for artificial hydrogels that mimic the properties of natural hydrogels to replace damaged ones or support and monitor their normal functioning. While morphologically adaptable soft and tough hydrogels have been applied to soft tissues, creating strong and stiff hydrogels to emulate stiff load-bearing connective tissues remains a challenge. Strategies and methods for strengthening and stiffening tough hydrogels are summarized to provide insights into fabricating hydrogels with a combination of strength, stiffness, and toughness to mimic natural load-bearing tissues.

ADVANCED NANOBIOMED RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Bone Fracture-Treatment Method: Fixing 3D-Printed Polycaprolactone Scaffolds with Hydrogel Type Bone-Derived Extracellular Matrix and β-Tricalcium Phosphate as an Osteogenic Promoter

Seokhwan Yun et al.

Summary: The bdECM-beta-TCP mixture demonstrated faster bone formation and reduced inflammatory response in rat calvarial defects, suggesting it as an ideal osteogenic promoter for treating fractures.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Multidisciplinary

Semi-convertible Hydrogel Enabled Photoresponsive Lubrication

Jian Wang et al.

Summary: The study demonstrates a semi-convertible hydrogel with reversible photo responsive supra-molecular lubricating ability, offering a possible way for fabricating novel smart devices beyond lubrication. This finding integrates supramolecular chemistry, hydrogel, and surface science into a new emerging branch of interdisciplinary materials science.

MATTER (2021)

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Article Pharmacology & Pharmacy

Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment

Xingwen Han et al.

Summary: The study aimed to investigate the effect of gelatin on stabilizing silver nanoparticles (AgNPs) and their potential use in bone fracture healing. Results showed that AgNPs-loaded Gel hydrogels are non-toxic to osteoblasts and can improve the survival and spreading of these cells, suggesting their potential in nursing care for bone fractures.

DRUG DELIVERY (2021)

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3D printing electrospinning fiber-reinforced decellularized extracellular matrix for cartilage regeneration

Weiming Chen et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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A collagen-based hydrogel containing tacrolimus for bone tissue engineering

Mir Hamed Nabavi et al.

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Bioinspired Mineral-Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Shumeng Bai et al.

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Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins

Takayuki Nonoyama et al.

ADVANCED MATERIALS (2020)

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Review Pharmacology & Pharmacy

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for in flammatory diseases

Wei He et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Orthopedics

Autologous Chondrocyte Implantation Versus Microfracture in the Knee: A Meta-analysis and Systematic Review

Guo-Hau Gou et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2020)

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Review Engineering, Biomedical

Progress in 3D bioprinting technology for tissue/organ regenerative engineering

Ishita Matai et al.

BIOMATERIALS (2020)

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Immunometabolism in the development of rheumatoid arthritis

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IMMUNOLOGICAL REVIEWS (2020)

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Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

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Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

Amy Y. Clark et al.

NATURE COMMUNICATIONS (2020)

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Gelatin Templated Polypeptide Co-Cross-Linked Hydrogel for Bone Regeneration

Yusen Qiao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Specialty Tough Hydrogels and Their Biomedical Applications

Stephanie Fuchs et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Materials Science, Biomaterials

Integration of Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes with Hydroxyapatite-Embedded Hyaluronic Acid-Alginate Hydrogel for Bone Regeneration

Shuo Yang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Advancements and Frontiers in the High Performance of Natural Hydrogels for Cartilage Tissue Engineering

Wuren Bao et al.

FRONTIERS IN CHEMISTRY (2020)

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Review Cell Biology

The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem

Isabelle Corre et al.

CELLS (2020)

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The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Integration of Macro-Cross-Linker and Metal Coordination: A Super Stretchable Hydrogel with High Toughness

Rita Das Mahapatra et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

High Lubricity Meets Load Capacity: Cartilage Mimicking Bilayer Structure by Brushing Up Stiff Hydrogels from Subsurface

Mingming Rong et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

Hongyuan Zhu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

Shuai Yue et al.

NANOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Dual delivery of stem cells and insulin-like growth factor-1 in coacervate-embedded composite hydrogels for enhanced cartilage regeneration in osteochondral defects

Hyeran Cho et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Nanoscience & Nanotechnology

MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection

Jie Yin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Engineering, Biomedical

Biological and mechanical performance and degradation characteristics of calcium phosphate cements in large animals and humans

Lena Schroeter et al.

ACTA BIOMATERIALIA (2020)

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Article Nanoscience & Nanotechnology

Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: From production to clinical practice

Niusha Nikravesh et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Review Materials Science, Biomaterials

Enhancement of the Mechanical Properties of Hydrogels with Continuous Fibrous Reinforcement

Laura E. Beckett et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Pharmacology & Pharmacy

Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

Yuefei Zhu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Review Biotechnology & Applied Microbiology

Recent Progress in 3D Printing of Elastic and High-Strength Hydrogels for the Treatment of Osteochondral and Cartilage Diseases

Wenli Dai et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Chemistry, Physical

Advances in Understanding Hydrogel Lubrication

Tooba Shoaib et al.

COLLOIDS AND INTERFACES (2020)

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Article Polymer Science

Poly(N,N′-Diethylacrylamide)-Based Thermoresponsive Hydrogels with Double Network Structure

Lenka Hanykova et al.

POLYMERS (2020)

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Article Multidisciplinary Sciences

Cartilage-inspired, lipid-based boundary-lubricated hydrogels

Weifeng Lin et al.

SCIENCE (2020)

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Review Chemistry, Multidisciplinary

Phototherapy with layered materials derived quantum dots

Houjuan Zhu et al.

NANOSCALE (2020)

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3D printing of bone tissue engineering scaffolds

Chong Wang et al.

BIOACTIVE MATERIALS (2020)

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Combinatorial effects of inorganic ions on adhesion and proliferation of osteoblast-like cells

Akiko Obata et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Hydrogels and Their Applications in Targeted Drug Delivery

Radhika Narayanaswamy et al.

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NATURE COMMUNICATIONS (2019)

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MATERIALS (2019)

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Article Instruments & Instrumentation

Topical delivery of 3,5,4-trimethoxy-trans-stilbene-loaded microemulsion-based hydrogel for the treatment of osteoarthritis in a rabbit model

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PHA-Based Thermogel as a Controlled Zero-Order Chemotherapeutic Delivery System for the Effective Treatment of Melanoma

Lu Jiang et al.

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Review Orthopedics

Current and novel injectable hydrogels to treat focal chondral lesions: Properties and applicability

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Methotrexate Aspasomes Against Rheumatoid Arthritis: Optimized Hydrogel Loaded Liposomal Formulation with In Vivo Evaluation in Wistar Rats

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AAPS PHARMSCITECH (2018)

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Effect of age on biomaterial-mediated in situ bone tissue regeneration

Mengqian Liu et al.

ACTA BIOMATERIALIA (2018)

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Article Engineering, Biomedical

Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration

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BIOMATERIALS (2018)

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Article Engineering, Environmental

Hybrid injectable platforms for the in situ delivery of therapeutic ions from mesoporous glasses

C. Pontremoli et al.

CHEMICAL ENGINEERING JOURNAL (2018)

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Review Biochemistry & Molecular Biology

Chemical crosslinking of biopolymeric scaffolds: Current knowledge and future directions of crosslinked engineered bone scaffolds

Ahmad Oryan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Medicine, General & Internal

Decellularized Hydrogels in Bone Tissue Engineering: A Topical Review

Andrea Pacifici et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2018)

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Article Chemistry, Multidisciplinary

Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy

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NANOSCALE (2018)

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Exosomes and regenerative medicine: state of the art and perspectives

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TRANSLATIONAL RESEARCH (2018)

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The Metabolic Microenvironment Steers Bone Tissue Regeneration

Julia Loeffler et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

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Review Engineering, Biomedical

Molecularly Engineered Biolubricants for Articular Cartilage

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ADVANCED HEALTHCARE MATERIALS (2018)

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Article Engineering, Biomedical

Thermoreversible Hyaluronic Acid-PNIPAAm Hydrogel Systems for 3D Stem Cell Culture

Barbara L. Ekerdt et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

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Multifunctional smart hydrogels: potential in tissue engineering and cancer therapy

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JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Endocrinology & Metabolism

Exosomes in Extracellular Matrix Bone Biology

Adrienn Petho et al.

CURRENT OSTEOPOROSIS REPORTS (2018)

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Multifunctional Surface Modification of Mulberry Silk Fabric via PNIPAAm/Chitosan/PEO Nanofibers Coating and Cross-Linking Technology

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COATINGS (2018)

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Review Biochemistry & Molecular Biology

Bone tissue engineering: Scaffold preparation using chitosan and other biomaterials with different design and fabrication techniques

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Article Materials Science, Biomaterials

Promotion of chondrogenic differentiation of mesenchymal stem cells by copper: Implications for new cartilage repair biomaterials

Changkui Xu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Hofmeister Effect-Assisted One Step Fabrication of Ductile and Strong Gelatin Hydrogels

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ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Nanoscience & Nanotechnology

Multifunctional Copper-Containing Carboxymethyl Chitosan/Alginate Scaffolds for Eradicating Clinical Bacterial Infection and Promoting Bone Formation

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ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Biotechnology & Applied Microbiology

Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models

Yingying Chi et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Review Oncology

Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy

Pablo Angulo et al.

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Dental and orofacial mesenchymal stem cells in craniofacial regeneration: The prosthodontist's point of view

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JOURNAL OF PROSTHETIC DENTISTRY (2017)

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Article Multidisciplinary Sciences

Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics

Nicolas Rauner et al.

NATURE (2017)

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Review Multidisciplinary Sciences

Advances in engineering hydrogels

Yu Shrike Zhang et al.

SCIENCE (2017)

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Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models

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ONCOTARGET (2017)

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Injectable hydrogels for cartilage and bone tissue engineering

Mei Liu et al.

BONE RESEARCH (2017)

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Article Clinical Neurology

Efficacy of Poly(D,L-Lactic Acid-co-Glycolic acid)Poly(Ethylene Glycol)-Poly(D, L-Lactic Acid-co-Glycolic Acid) Thermogel As a Barrier to Prevent Spinal Epidural Fibrosis in a Postlaminectomy Rat Model

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CLINICAL SPINE SURGERY (2017)

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Article Biochemistry & Molecular Biology

Reproducible Dendronized PEG Hydrogels via SPAAC Cross-Linking

Sabrina M. Hodgson et al.

BIOMACROMOLECULES (2017)

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Review Chemistry, Multidisciplinary

The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering

Yulin Li et al.

CHEMICAL REVIEWS (2017)

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Review Polymer Science

Hydrogels for Biomedical Applications: Their Characteristics and the Mechanisms behind Them

Qinyuan Chai et al.

GELS (2017)

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Hydrogels for Therapeutic Delivery: Current Developments and Future Directions

Sytze J. Buwalda et al.

BIOMACROMOLECULES (2017)

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Novel self-assembled tacrolimus nanoparticles cross-linking thermosensitive hydrogels for local rheumatoid arthritis therapy

Huimin Wu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Review Materials Science, Multidisciplinary

A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers

Stefanie Utech et al.

JOURNAL OF MATERIALS SCIENCE (2016)

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Article Chemistry, Physical

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

Ovijit Chaudhuri et al.

NATURE MATERIALS (2016)

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Article Engineering, Biomedical

Photocrosslinkable Gelatin Hydrogel for Epidermal Tissue Engineering

Xin Zhao et al.

ADVANCED HEALTHCARE MATERIALS (2016)

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Controlling Hydrogel Mechanics via Bio-Inspired Polymer-Nanoparticle Bond Dynamics

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ACS NANO (2016)

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Indications and Outcomes for Microfracture as an Adjunct to Hip Arthroscopy for Treatment of Chondral Defects in Patients With Femoroacetabular Impingement: A Systematic Review

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ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2016)

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Article Engineering, Biomedical

Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy

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BIOMATERIALS (2016)

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Article Chemistry, Multidisciplinary

New Linear and Star-Shaped Thermogelling Poly([R]-3-hydroxybutyrate) Copolymers

Ghislaine Barouti et al.

CHEMISTRY-A EUROPEAN JOURNAL (2016)

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Long-term results of microfracture in the treatment of talus osteochondral lesions

Gokhan Polat et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2016)

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Review Biochemistry & Molecular Biology

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

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MOLECULES (2016)

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Review Rheumatology

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk

Steven R. Goldring et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

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Article Engineering, Chemical

Biodegradable and biocompatible temperature sensitive triblock copolymer hydrogels as draw agents for forward osmosis

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SEPARATION AND PURIFICATION TECHNOLOGY (2016)

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Methods of synthesis of hydrogels ... A review

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SAUDI PHARMACEUTICAL JOURNAL (2016)

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Polymers in Cartilage Defect Repair of the Knee: Current Status and Future Prospects

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POLYMERS (2016)

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Designing hydrogels for controlled drug delivery

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NATURE REVIEWS MATERIALS (2016)

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Injected nanocrystals for targeted drug delivery

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ACTA PHARMACEUTICA SINICA B (2016)

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Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside

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IMMUNE NETWORK (2016)

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Review Cell & Tissue Engineering

A review of hydrogel use in fracture healing and bone regeneration

David M. R. Gibbs et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

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Review Cell & Tissue Engineering

Current research on pharmacologic and regenerative therapies for osteoarthritis

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BONE RESEARCH (2016)

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Article Engineering, Biomedical

Nanostructured hydroxyapatite surfaces-mediated adsorption alters recognition of BMP receptor IA and bioactivity of bone morphogenetic protein-2

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ACTA BIOMATERIALIA (2015)

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Review Pharmacology & Pharmacy

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Rachit Agarwal et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

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Review Polymer Science

Biomedical applications of hydrogels: A review of patents and commercial products

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Individual risk factors for deep infection and compromised fracture healing after intramedullary nailing of tibial shaft fractures: A single centre experience of 480 patients

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INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2015)

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3-Dimensional cell-laden nano-hydroxyapatite/protein hydrogels for bone regeneration applications

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MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2015)

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A synthetic hydrogel for the high-throughput study of cell-ECM interactions

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NATURE COMMUNICATIONS (2015)

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Rapid Self-Integrating, Injectable Hydrogel for Tissue Complex Regeneration

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ADVANCED HEALTHCARE MATERIALS (2015)

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Hydrogel: Preparation, characterization, and applications: A review

Enas M. Ahmed

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Bioglass/alginate composite hydrogel beads as cell carriers for bone regeneration

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2014)

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Hydrogels in a historical perspective: From simple networks to smart materials

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JOURNAL OF CONTROLLED RELEASE (2014)

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Review Chemistry, Multidisciplinary

Synthetic biodegradable functional polymers for tissue engineering: a brief review

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SCIENCE CHINA-CHEMISTRY (2014)

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Hydrogels for tissue engineering and regenerative medicine

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JOURNAL OF MATERIALS CHEMISTRY B (2014)

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Current Perspectives in Mesenchymal Stem Cell Therapies for Osteoarthritis

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STEM CELLS INTERNATIONAL (2014)

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The calcium silicate/alginate composite: Preparation and evaluation of its behavior as bioactive injectable hydrogels

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ACTA BIOMATERIALIA (2013)

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Mechanical & Cell Culture Properties of Elastin-Like Polypeptide, Collagen, Bioglass, and Carbon Nanosphere Composites

Tyler S. Wheeler et al.

ANNALS OF BIOMEDICAL ENGINEERING (2013)

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Review Immunology

Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2013)

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Review Pharmacology & Pharmacy

Microneedles for intradermal and transdermal drug delivery

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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Effect of Gelatin Hydrogel Sheet Containing Basic Fibroblast Growth Factor on Proximal Sesamoid Bone Transverse Fracture Healing in the Horse

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JOURNAL OF EQUINE VETERINARY SCIENCE (2013)

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Review Cell & Tissue Engineering

Rat defect models for bone grafts and tissue engineered bone constructs

Joong-Hyun Kim et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2013)

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Bone graft substitutes currently available in orthopaedic practice THE EVIDENCE FOR THEIR USE

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BONE & JOINT JOURNAL (2013)

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Review Cell & Tissue Engineering

Bone Regeneration Based on Tissue Engineering Conceptions - A 21st Century Perspective

Jan Henkel et al.

BONE RESEARCH (2013)

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Purification and identification of antioxidant peptides from egg white protein hydrolysate

Chen Chen et al.

AMINO ACIDS (2012)

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Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography

Robert Gauvin et al.

BIOMATERIALS (2012)

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Injectable hydrogels for bone and cartilage repair

Ashley A. Amini et al.

BIOMEDICAL MATERIALS (2012)

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Hydrogels for Protein Delivery

Tina Vermonden et al.

CHEMICAL REVIEWS (2012)

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Intermediate Outcomes of Fresh Talar Osteochondral Allografts for Treatment of Large Osteochondral Lesions of the Talus

Roger Haene et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2012)

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Review Orthopedics

Osteoarthritis year 2012 in review: clinical

M. C. Hochberg

OSTEOARTHRITIS AND CARTILAGE (2012)

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Review Multidisciplinary Sciences

Unlike Bone, Cartilage Regeneration Remains Elusive

Daniel J. Huey et al.

SCIENCE (2012)

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Article Engineering, Biomedical

An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects

Yash M. Kolambkar et al.

BIOMATERIALS (2011)

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Article Engineering, Biomedical

Hydrogel design for cartilage tissue engineering: A case study with hyaluronic acid

Iris L. Kim et al.

BIOMATERIALS (2011)

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Review Engineering, Biomedical

A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics

Alexander Hoppe et al.

BIOMATERIALS (2011)

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Review Chemistry, Multidisciplinary

Biopolymer-Based Hydrogels for Cartilage Tissue Engineering

Biji Balakrishnan et al.

CHEMICAL REVIEWS (2011)

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Review Pharmacology & Pharmacy

Formulation approaches in enhancement of patient compliance to oral drug therapy

Aliasgar Shahiwala

EXPERT OPINION ON DRUG DELIVERY (2011)

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Review Polymer Science

Biomedical Applications of Biodegradable Polymers

Bret D. Ulery et al.

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS (2011)

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Review Pharmacology & Pharmacy

Drug delivery to solid tumors by elastin-like polypeptides

Jonathan R. McDaniel et al.

ADVANCED DRUG DELIVERY REVIEWS (2010)

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Article Engineering, Biomedical

Characterization of cyclic acetal hydroxyapatite nanocomposites for craniofacial tissue engineering

Minal Patel et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2010)

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Article Orthopedics

Childhood Obesity and Low-Velocity Knee Dislocation in a Fifteen-Year-Old Girl A Case Report

Tracy Hamblin et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2010)

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Review Rheumatology

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

Jeremie Sellam et al.

NATURE REVIEWS RHEUMATOLOGY (2010)

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Editorial Material Public, Environmental & Occupational Health

BONE HEALTH: PREVENTING OSTEOPOROSIS

Regina M. Benjamin

PUBLIC HEALTH REPORTS (2010)

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Article Chemistry, Medicinal

Particle size reduction for improvement of oral absorption of the poorly soluble drug UG558 in rats during early development

Kalle Sigfridsson et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2009)

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Article Orthopedics

Drilling and Microfracture Lead to Different Bone Structure and Necrosis during Bone-Marrow Stimulation for Cartilage Repair

Hongmei Chen et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2009)

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Article Engineering, Biomedical

Sonication-induced gelation of silk fibroin for cell encapsulation

Xiaoqin Wang et al.

BIOMATERIALS (2008)

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Article Orthopedics

Tissue engineering of bone: Material and matrix considerations

Yusuf Khan et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2008)

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Review Dentistry, Oral Surgery & Medicine

Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis

Z. S. Ai-Aql et al.

JOURNAL OF DENTAL RESEARCH (2008)

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Article Orthopedics

Cartilage repair with osteochondral autografts in sheep: Effect of biophysical stimulation with pulsed electromagnetic fields

Franco Benazzo et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2008)

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Review Orthopedics

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

W. Zhang et al.

OSTEOARTHRITIS AND CARTILAGE (2008)

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Review Polymer Science

Hydrogels in drug delivery: Progress and challenges

Todd R. Hoare et al.

POLYMER (2008)

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Review Pharmacology & Pharmacy

Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering

Soo-Hong Lee et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Review Cell & Tissue Engineering

Review: Mineralization of synthetic polymer scaffolds for bone tissue engineering

James D. Kretlow et al.

TISSUE ENGINEERING (2007)

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Article Chemistry, Multidisciplinary

Novel polymeric microspheres containing norcantharidin for chemoembolization

Xiaohua Liu et al.

JOURNAL OF CONTROLLED RELEASE (2006)

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Review Multidisciplinary Sciences

Designing materials for biology and medicine

R Langer et al.

NATURE (2004)

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Article Engineering, Biomedical

Hydrogels for combination delivery of antineoplastic agents

KH Bouhadir et al.

BIOMATERIALS (2001)

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Article Biochemistry & Molecular Biology

Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: Activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP

N Gabarin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2001)

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Article Polymer Science

New stimuli-responsive copolymers of N-acryloyl-N '-alkyl piperazine and methyl methacrylate and their hydrogels

LH Gan et al.

POLYMER (2001)

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