Extracellular vesicles as a novel photosensitive drug delivery system for enhanced photodynamic therapy

Article Engineering, Biomedical

Tumor-derived exosomes co-delivering aggregation-induced emission luminogens and proton pump inhibitors for tumor glutamine starvation therapy and enhanced type-I photodynamic therapy

Daoming Zhu et al.

Summary: In this research, tumor-derived exosomes were used to co-deliver AIEgens and PPI for tumor combination therapy. Inhibition of tumor cell glutamine metabolism enhanced the effect of photodynamic therapy.

BIOMATERIALS (2022)

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Article Biotechnology & Applied Microbiology

M1-derived extracellular vesicles enhance photodynamic therapy and promote immunological memory in preclinical models of colon cancer

Ruben V. Huis in't Veld et al.

Summary: Extracellular vesicles (EVs) show promising potential as drug carriers for photodynamic therapy (PDT) in cancer treatment. This study compares the antitumor efficacy of EV-mediated PDT derived from different cell sources, and highlights the importance of cell type and immunological state in determining its effectiveness.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Biosynthetic Dendritic Cell-Exocytosed Aggregation-Induced Emission Nanoparticles for Synergistic Photodynamic Immunotherapy

Hongmei Cao et al.

Summary: A strategy is developed to generate DEV-AIE nanoparticles by using DCs as a cell reactor, enabling synergistic photodynamic immunotherapy for effective tumor treatment and inhibition of cancer stem cells.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Conscription of Immune Cells by Light-Activatable Silencing NK-Derived Exosome (LASNEO) for Synergetic Tumor Eradication

Mengjie Zhang et al.

Summary: This study proposes a new type of light-activatable exosomes derived from NK cells, which can achieve tumor treatment by generating reactive oxygen species and gene silencing. These exosomes not only exhibit strong cytotoxicity, but also recruit various types of immune cells to restore immunological surveillance in the tumor microenvironment. The manufacturing process is simple and controllable, showing great potential.

ADVANCED SCIENCE (2022)

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Article Pharmacology & Pharmacy

Investigations on Cellular Uptake Mechanisms and Immunogenicity Profile of Novel Bio-Hybrid Nanovesicles

Yi-Hsuan Ou et al.

Summary: Nanovesicles that combine cellular and synthetic components (nCVTs) have shown promise as targeted cancer treatment. This study investigated the cytotoxicity, immune activation, and uptake mechanisms of nCVTs compared to liposomes and nano-cellular membranes. The results showed that nCVTs had significantly higher cellular internalization and used receptor-mediated processes for uptake. Furthermore, nCVTs exhibited low immunostimulatory potential both in vitro and in vivo.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

A Low-Cost High-Performance Data Augmentation for Deep Learning-Based Skin Lesion Classification

Shuwei Shen et al.

Summary: This article proposes a high-performance data augmentation strategy for intelligent skin cancer screening devices that can be deployed in rural or underdeveloped communities. The strategy improves the classification performance of skin lesions and highlights potential regions of interest for clinicians. It can also be applied to early screening and diagnosis of other diseases in different clinical disciplines.

BME FRONTIERS (2022)

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Article Engineering, Environmental

Micro fluidics for extracellular vesicle separation and mimetic synthesis: Recent advances and future perspectives

Yingchao Meng et al.

Summary: Microfluidic technologies are gaining interest for their potential in fast and efficient extracellular vesicle processing, highlighting recent advances in EV separation and mimetics synthesis for drug delivery applications. The discussion also touches on the advantages and drawbacks of current technologies, as well as addressing future challenges and applications in the field.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Multidisciplinary Sciences

A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy

Wei Tang et al.

Summary: The study introduces a novel nanomaterial assembly that significantly alleviates tumor hypoxia and enhances radiotherapy efficacy by increasing intratumoral oxygen supply while reducing oxygen consumption, demonstrating a potential strategy to address a major limitation in radiotherapy.

NATURE COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Nkune Williams Nkune et al.

Summary: Metastatic melanoma is a challenging skin malignancy with resistance to traditional therapies, but photodynamic therapy with nanoparticles and targeting moieties shows promise. However, research in three-dimensional cell culture models using active PS nanoparticle-mediated platforms for PDT treatment of MM is limited and requires further investigation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Photosensitive drug delivery systems for cancer therapy: Mechanisms and applications

Patrick Pan et al.

Summary: Photosensitive nanoparticles have been developed as potential therapies in human health, particularly in cancer treatment through photodynamic and photothermal therapy. These nanoparticles achieve controlled drug release via phototriggerable mechanisms, with recent research focusing on improving treatment efficacy and safety.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biochemistry & Molecular Biology

Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy

Shujin Lin et al.

Summary: Photodynamic therapy (PDT) is a promising treatment method due to its efficiency and accuracy, with viral nanoparticles (VNPs) showing great potential as delivery vehicles for PDT. VNPs have favorable properties and are being explored for applications in tumor cell treatment and antimicrobial therapy, with future prospects focusing on developing novel viral nanocarriers or improving existing viral vectors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Exosome-based photoacoustic imaging guided photodynamic and immunotherapy for the treatment of pancreatic cancer

Yongho Jang et al.

Summary: In this study, tumor-derived reassembled exosome (R-Exo) was used both as a drug delivery carrier and an immunostimulatory agent for cancer therapy. By loading chlorin e6 photosensitizer into R-Exo, it retained its original size and membrane proteins for targeting tumor cells. The modified exosomes were able to generate reactive oxygen species and increase cytokine release from immune cells, showing their potential as an immunotherapeutic agent.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Multidisciplinary Sciences

The genetic source tracking of human urinary exosomes

Qingfu Zhu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Oncology

Extracellular Vesicle (EV) biohybrid systems for cancer therapy: Recent advances and future perspectives

Yi-Hsuan Ou et al.

Summary: Extracellular vesicles (EVs) are explored as next-generation drug delivery systems for cancer therapy due to their endogenous origin, while EV-biohybrid nano-DDSs, combining EVs with conventional synthetic nanoDDSs, offer a potential alternative to overcome limitations and enhance therapeutic outcomes in cancer treatment.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

Pol Escude Martinez de Castilla et al.

Summary: This systematic review assesses the characteristics and trends of extracellular vesicles (EVs) in pre-clinical applications, providing a reliable basis for future applications of EVs in drug delivery and serving as a reference for regulatory guidelines.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

Artificial exosomes mediated spatiotemporal-resolved and targeted delivery of epigenetic inhibitors

Huan Li et al.

Summary: The study introduced a novel drug delivery system, EMS, with high loading efficiency of SAHA. EMS can be targeted to tumor tissues through integrin α4β1, leading to superior anti-tumor effects in lung cancer therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis via Inhibition of AOC1

Yumei Rong et al.

Summary: Combining photodynamic therapy (PDT) with a novel photosensitizer LD4 for treating ulcerative colitis (UC) in rat models can improve survival rates, modulate expression of inflammatory factors, protect intestinal epithelial integrity, rebuild intestinal microflora balance, and reprogram protein expression profiles. AOC(1) emerges as a potential target in this efficient UC treatment approach using LD4-PDT.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor

Changguo Gong et al.

Summary: Research shows that under low-pH conditions, the uptake efficiency of tumor exosomes increases while retaining cell specificity. A glycerolipid self-aggregation-based mechanism is revealed through lipidomics analysis and molecular simulations to enhance homologous uptake. By using near-infrared irradiation to induce exosome rupture and release chemodrugs, a smart drug delivery platform is developed for enhanced antitumor effects.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Singlet Oxygen Afterglow Therapy with NIR-II Fluorescent Molecules

Jianhua Zou et al.

Summary: The synthesized ABDPTPA is an efficient heavy-atom-free photosensitizer that can improve the lifespan of O-1(2) under dark and hypoxic conditions. Its high O-1(2) quantum yield and ability to promote O-1(2) awakening make it suitable for phototherapy to enhance tumor regression.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system

Saeid Moghassemi et al.

Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Nanoscience & Nanotechnology

Extracellular vesicles as a next-generation drug delivery platform

Inge Katrin Herrmann et al.

Summary: Extracellular vesicles play a crucial role in cell-to-cell communication and can serve as drug carriers with advantages over synthetic carriers. However, clinical translation of extracellular vesicle-based therapies remains challenging, requiring further research and development efforts.

NATURE NANOTECHNOLOGY (2021)

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Article Nutrition & Dietetics

Lactobacillus rhamnosus GG Derived Extracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory in DSS-Induced Colitis Mice

Lingjun Tong et al.

Summary: Probiotic LGG-EVs show potential in attenuating colitis by inhibiting the TLR4-NF-kappa B-NLRP3 signaling pathway, reducing the release of pro-inflammatory cytokines, and reshaping gut microbiota. These findings suggest a promising therapeutic approach for colitis using oral gavage of LGG-EVs.

NUTRIENTS (2021)

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Article Chemistry, Multidisciplinary

Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method

Daoming Zhu et al.

Summary: This study developed a novel bacteria-based AIEgen hybrid system that can facilitate hypoxia-tolerant PDT treatment of orthotopic colon tumors through an interventional method, significantly impairing tumor growth and overcoming PDT defects.

ADVANCED SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Photodynamic Therapy-Current Limitations and Novel Approaches

Gurcan Gunaydin et al.

Summary: Photodynamic therapy (PDT) relies on generating singlet oxygen through photosensitizer excitation to destroy target tumor cells. Despite significant progress over the last century, PDT's broad clinical application is hindered by various limitations related to light, tissue oxygenation, and photosensitizer properties.

FRONTIERS IN CHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Zinc-Phthalocyanine-Loaded Extracellular Vesicles Increase Efficacy and Selectivity of Photodynamic Therapy in Co-Culture and Preclinical Models of Colon Cancer

Pablo Lara et al.

Summary: This study presents a simple strategy to enhance the distribution, selectivity, and efficacy of the lipophilic PS ZnPc in colon cancer by stabilizing them in EVs. The preferential uptake of EV-ZnPc towards colon cancer cells was observed in co-culture models. In vivo assays demonstrated that EV-ZnPc could target tumor cells and reduce tumor growth significantly over a period of 15 days.

PHARMACEUTICS (2021)

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Article Medicine, Research & Experimental

Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy

Jianbing Du et al.

Summary: This study successfully designed an exosome-based platform to deliver ferroptosis inducer and photosensitizer into liver cancer cells, inducing cell death significantly while minimizing toxicity to the liver and kidney.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the microbiota

Lingjun Tong et al.

Summary: This study demonstrates that mEVs alleviate colitis by regulating intestinal immune homeostasis via inhibiting TLR4-NF-kappa B and NLRP3 signaling pathways, restoring Treg/Th17 cell balance, and reshaping the gut microbiota. The findings suggest that mEVs have the potential to be a therapeutic approach for inflammatory bowel diseases.

THERANOSTICS (2021)

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Article Ophthalmology

Outcome of half-dose photodynamic therapy in chronic central serous chorioretinopathy with fovea-involving atrophy

Thomas J. van Rijssen et al.

Summary: The study evaluated the clinical outcomes after half-dose PDT in cCSC patients with pre-existing fovea-involving atrophy. It found that anatomical changes may occur after treatment, but functional improvements are limited. Early treatment with half-dose PDT before the occurrence of such atrophy is recommended to optimize outcomes.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

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Article Engineering, Biomedical

Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

Shaojun Pan et al.

BIOMATERIALS (2020)

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Article Engineering, Environmental

Nucleus-targeting near-infrared nanoparticles based on TAT peptide-conjugated IR780 for photo-chemotherapy of breast cancer

Guoyun Wan et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Pharmacology & Pharmacy

Nanoparticle-based drug delivery systems for controllable photodynamic cancer therapy

Yilin Zheng et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Review Pharmacology & Pharmacy

Extracellular vesicles as drug delivery systems: Why and how?

Omnia M. Elsharkasy et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Tumor-Exocytosed Exosome/Aggregation-Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy

Daoming Zhu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Biotechnology & Applied Microbiology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Editorial Material Chemistry, Medicinal

Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

Vanna Sanna et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

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Article Biotechnology & Applied Microbiology

Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6

Bobin Mi et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Materials Science, Biomaterials

Tumor-Targeting Polycaprolactone Nanoparticles with Codelivery of Paclitaxel and IR780 for Combinational Therapy of Drug-Resistant Ovarian Cancer

Qianqian Pan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Food Science & Technology

Oral Administration of Bovine Milk-Derived Extracellular Vesicles Alters the Gut Microbiota and Enhances Intestinal Immunity in Mice

Lingjun Tong et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

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Article Medicine, Research & Experimental

Selective photodynamic effects on cervical cancer cells provided by P123 Pluronic ?-based nanoparticles modulating hypericin delivery

Gabrielle Marconi Zago Ferreira Damke et al.

LIFE SCIENCES (2020)

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Review Biochemistry & Molecular Biology

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

Karim Sidhom et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Nanoscience & Nanotechnology

Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles

Yun-jing Hou et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Medicinal

Conjugated Photosensitizers for Imaging and PDT in Cancer Research

Joao C. S. Simoes et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Biotechnology & Applied Microbiology

Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis

Feili Yan et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Review Oncology

Progress in Clinical Trials of Photodynamic Therapy for Solid Tumors and the Role of Nanomedicine

Hashem O. Alsaab et al.

CANCERS (2020)

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Article Nanoscience & Nanotechnology

Intelligent Size-Changeable Nanoparticles for Enhanced Tumor Accumulation and Deep Penetration

Wenqi Yu et al.

ACS APPLIED BIO MATERIALS (2020)

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Review Oncology

Size-Exclusion Chromatography as a Technique for the Investigation of Novel Extracellular Vesicles in Cancer

Daniel S. K. Liu et al.

CANCERS (2020)

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Review Biotechnology & Applied Microbiology

Recent Advancements in the Loading and Modification of Therapeutic Exosomes

Mengqiao Xu et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biology

Enhanced anti-tumor efficacy of 5-aminolevulinic acid-gold nanoparticles-mediated photodynamic therapy in cutaneous squamous cell carcinoma cells

Yu-fei Chi et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2020)

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Article Medicine, Research & Experimental

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

Li Qiao et al.

THERANOSTICS (2020)

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Article Pharmacology & Pharmacy

Photodynamic therapy - hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity

Nikola Plenagl et al.

DRUG DELIVERY (2019)

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Article Chemistry, Multidisciplinary

Photodynamic Therapy with Liposomes Encapsulating Photosensitizers with Aggregation-Induced Emission

Yang Yang et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

Qingwei Zhu et al.

ADVANCED SCIENCE (2019)

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Article Oncology

PEGylated doped- and undoped-TiO2 nanoparticles for photodynamic Therapy of cancers

Zahir Shah et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2019)

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Review Chemistry, Multidisciplinary

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

Olivier G. de Jong et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Cell Biology

Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation

Alexandra Brahmer et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Engineering, Biomedical

Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy

Hong Cheng et al.

BIOMATERIALS (2019)

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Review Chemistry, Multidisciplinary

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

Mingying Yang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Oncology

A framework for the development of effective anti-metastatic agents

Robin L. Anderson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Delivery technologies for cancer immunotherapy

Rachel S. Riley et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Cell Biology

Autologous tumor cell-derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion

Mengfei Guo et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Extracellular vesicle isolation methods: rising impact of size-exclusion chromatography

Marta Monguio-Tortajada et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Designer Exosomes for Active Targeted Chemo-Photothermal Synergistic Tumor Therapy

Jie Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Real-Time and High-Resolution Bioimaging with Bright Aggregation-Induced Emission Dots in Short-Wave Infrared Region

Ji Qi et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Bright Aggregation-Induced-Emission Dots for Targeted Synergetic NIR-II Fluorescence and NIR-I Photoacoustic Imaging of Orthotopic Brain Tumors

Zonghai Sheng et al.

ADVANCED MATERIALS (2018)

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Article Biochemical Research Methods

Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling

Meng Ding et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018)

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Review Medicine, Research & Experimental

Photodynamic therapy - mechanisms, photosensitizers and combinations

Stanislaw Kwiatkowski et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Oncology

Nanoparticle-based photothermal and photodynamic immunotherapy for tumor treatment

Xiaoyang Hou et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

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Review Nanoscience & Nanotechnology

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

Nadda Muhamad et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Chemistry, Multidisciplinary

Self-Assembly of Extracellular Vesicle-like Metal-Organic Framework Nanoparticles for Protection and Intracellular Delivery of Biofunctional Proteins

Gong Cheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Oncology

A review of nanoparticle photosensitizer drug delivery uptake systems for photodynamic treatment of lung cancer

Mpho Gift Mokwena et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2018)

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Article Cell Biology

Plasma exosomes induced by remote ischaemic preconditioning attenuate myocardial ischaemia/reperfusion injury by transferring miR-24

Wen Minghua et al.

CELL DEATH & DISEASE (2018)

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Review Multidisciplinary Sciences

Progress and challenges towards targeted delivery of cancer therapeutics

Daniel Rosenblum et al.

NATURE COMMUNICATIONS (2018)

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Review Immunology

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Eduard Willms et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Photodynamic Therapy for Metastatic Melanoma Treatment: A Review

Channay Naidoo et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2018)

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Review Medicine, Research & Experimental

Theranostics based on AIEgens

Dong Wang et al.

THERANOSTICS (2018)

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Review Nanoscience & Nanotechnology

Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine

Chunlei Zhu et al.

ACS APPLIED BIO MATERIALS (2018)

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Article Cell Biology

Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine

Eline Oeyen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biochemistry & Molecular Biology

EXOPLEXs: Chimeric Drug Delivery Platform from the Fusion of Cell-Derived Nanovesicles and Liposomes

Wei Jiang Goh et al.

BIOMACROMOLECULES (2018)

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Article Pharmacology & Pharmacy

Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl) chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases

Jos W. H. Wennink et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Multidisciplinary Sciences

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar et al.

NATURE (2017)

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Review Immunology

Nanoparticles and innate immunity: new perspectives on host defence

Diana Boraschi et al.

SEMINARS IN IMMUNOLOGY (2017)

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Article Cell Biology

Upconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation

Xiaobo B. Han et al.

CELL DEATH & DISEASE (2017)

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Review Medicine, Research & Experimental

Progress in Exosome Isolation Techniques

Pin Li et al.

THERANOSTICS (2017)

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Article Pharmacology & Pharmacy

Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin

Farrukh Aqil et al.

AAPS JOURNAL (2017)

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Article Engineering, Biomedical

Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain

Dongfen Yuan et al.

BIOMATERIALS (2017)

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Article Chemistry, Multidisciplinary

Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

Yoosoo Yang et al.

ADVANCED MATERIALS (2017)

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Article Cell Biology

Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography

Kristine Blans et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Review Biochemistry & Molecular Biology

New photosensitizers for photodynamic therapy

Heidi Abrahamse et al.

BIOCHEMICAL JOURNAL (2016)

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Article Nanoscience & Nanotechnology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Article Multidisciplinary Sciences

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Joanna Kowal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

Barbara W. Sodar et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles' characteristics compared to precipitating agents

Ana Gamez-Valero et al.

SCIENTIFIC REPORTS (2016)

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Article Gastroenterology & Hepatology

Photodynamic Therapy Relieves Colitis and Prevents Colitis-associated Carcinogenesis in Mice

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