4.7 Article

Thermosensitive hydrogel loaded with concentrated growth factors promote bone repair in segmental bone defects

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Biomedical

Engineering Multifunctional Hydrogel-Integrated 3D Printed Bioactive Prosthetic Interfaces for Osteoporotic Osseointegration

Zuhao Li et al.

Summary: In order to address the high risk issues in joint replacement surgery, a novel class of multifunctional hydrogel-integrated 3D printed bioactive prosthetic interfaces has been developed, which can promote osseointegration and inhibit infection in osteoporotic environment.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Chemistry, Multidisciplinary

A Lysosome-Activated Tetrahedral Nanobox for Encapsulated siRNA Delivery

Yang Gao et al.

Summary: Researchers have developed a dynamic lysosome-activated tetrahedral framework nucleic acid (tFNA) nanobox for encapsulating siRNA and achieving controlled release in cells, demonstrating excellent RNA protection and release effects.

ADVANCED MATERIALS (2022)

Article Engineering, Environmental

Repair of infected bone defect with Clindamycin-Tetrahedral DNA nanostructure Complex-loaded 3D bioprinted hybrid scaffold

Jun Li et al.

Summary: This study proposes a novel approach combining tetrahedral DNA nanostructure (TDN) with 3D bioprinting to treat infected bone defects. The results demonstrate that a bioprinted scaffold loaded with TDN and antibiotics shows promising efficacy in treating infected bone defects in a rat model. This research has significant implications for the treatment of infected bone defects.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Materials Science, Multidisciplinary

Ultrasound-mediated rapamycin delivery for promoting osseointegration of 3D printed prosthetic interfaces via autophagy regulation in osteoporosis

Zuhao Li et al.

Summary: The study introduces a new therapy combining 3D printed prostheses and transdermal ultrasound-mediated rapamycin delivery to promote osseointegration in an osteoporotic environment. By regulating autophagy levels, cell viability, proliferation, migration, and osteogenesis of osteoporosis-derived bone marrow mesenchymal stem cells (OP-BMSCs) were restored, and potential osteoclast-inducing capacity and adipogenic differentiation were inhibited. The therapy significantly improved bone ingrowth and osseointegration of prosthetic interfaces.

MATERIALS & DESIGN (2022)

Article Cell & Tissue Engineering

Regenerative Potential of Solid Bone Marrow Aspirate Concentrate Compared with Platelet-Rich Fibrin

Masateru Koyanagi et al.

Summary: This study investigates the regenerative potential of blood/bone marrow aspirate concentrates obtained from arterial blood, venous blood, and bone marrow aspirate. The results show that solid-type bone marrow aspirate concentrate (sBMAC) has a greater migratory potential and higher levels of certain mRNA compared to arterial blood-derived PRF (Ar-PRF) and venous blood-derived PRF (Ve-PRF), suggesting that sBMAC may be a promising candidate for promoting wound healing and bone regeneration.

TISSUE ENGINEERING PART A (2022)

Article Nanoscience & Nanotechnology

Lotus Seedpod-Inspired Crosslinking-Assembled Hydrogels Based on Gold Nanoclusters for Synergistic Osteosarcoma Multimode Imaging and Therapy

Zhe Yang et al.

Summary: Inspired by lotus seedpods, injectable hydrogels with long-term retention were developed for synergistic osteosarcoma treatment. The hydrogels effectively treated osteosarcoma using photothermal therapy and reduced metabolic toxicity.

ACS APPLIED MATERIALS & INTERFACES (2022)

Review Engineering, Chemical

Emerging Delivery Strategies of Platelet-Rich Plasma with Hydrogels for Wound Healing

Ya Zhang et al.

Summary: This review introduces the state of the art of hydrogels used to load PRP for wound treatments, emphasizing the importance of controlling release and mechanical properties to improve the clinical effect of PRP and promote a conducive wound repair environment.

ADVANCES IN POLYMER TECHNOLOGY (2022)

Article Chemistry, Multidisciplinary

Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral-Framework Nucleic-Acid Nanostructures Functionalized with Osteogenic Growth Peptide

Tianxu Zhang et al.

Summary: OGP-tFNAs can protect hematopoietic cells and their microenvironment from chemotherapy-induced injuries and myelosuppression, while promoting hematopoiesis regeneration.

ADVANCED SCIENCE (2022)

Article Engineering, Biomedical

A Nanozyme-Immobilized Hydrogel with Endogenous ROS-Scavenging and Oxygen Generation Abilities for Significantly Promoting Oxidative Diabetic Wound Healing

Zuhao Li et al.

Summary: This study introduces a biological metabolism-inspired hydrogel for ameliorating the unfavorable microenvironment of diabetic wounds. The hydrogel has the ability to capture reactive oxygen species (ROS) and generate oxygen to promote wound healing, protecting skin cells from death and proliferation inhibition. Treatment with the hydrogel accelerates wound healing and induces macrophage polarization from pro-inflammatory to anti-inflammatory phenotype.

ADVANCED HEALTHCARE MATERIALS (2022)

Review Chemistry, Physical

Nanozymes for Regenerative Medicine

Xiaozhou Mou et al.

Summary: This review summarizes the application potentials and recent advances of nanozymes in regeneration medicine, including catalytic mechanisms, strategies to improve biocompatibility, and applications in various fields of tissue regeneration medicine.

SMALL METHODS (2022)

Article Engineering, Biomedical

Autoclaving of Poloxamer 407 hydrogel and its use as a drug delivery vehicle

Mary Catherine Beard et al.

Summary: Autoclaving decreased the water content and gelation temperature of P407 hydrogel, but did not affect its rheological properties and efficacy as a drug delivery vehicle for vancomycin.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

Article Chemistry, Applied

Bioactive chitosan biguanidine-based injectable hydrogels as a novel BMP-2 and VEGF carrier for osteogenesis of dental pulp stem cells

Baharak Divband et al.

Summary: Injectable hydrogels loaded with VEGF and BMP-2 promote proliferation and osteogenic differentiation of DPSCs, showing potential for bone defect treatment.

CARBOHYDRATE POLYMERS (2021)

Article Materials Science, Multidisciplinary

pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

Zuhao Li et al.

Summary: A self-healing, injectable, and pH responsive hydrogel was successfully synthesized and incorporated with insulin glargine, showing promising potential in accelerating the healing of diabetic foot ulcers by shortening the inflammatory phase, promoting tissue formation, and improving treatment outcomes.

MATERIALS & DESIGN (2021)

Review Engineering, Biomedical

Advanced Strategies of Biomimetic Tissue-Engineered Grafts for Bone Regeneration

Chang Xie et al.

Summary: This review focuses on strategies of engineered grafts for bone regeneration, emphasizing physicochemical properties and structure optimization to enhance bone regeneration, as well as biological strategies to increase repair efficiency.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification

Hwan D. Kim et al.

Summary: A biomimetic scaffold has been developed to rapidly regenerate bone tissue in animal models, showing promise for application in human bone regeneration.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Cell & Tissue Engineering

Extracorporeal Shock Wave Combined with Teriparatide-Loaded Hydrogel Injection Promotes Segmental Bone Defects Healing in Osteoporosis

Qi Chen et al.

Summary: The study aims to investigate the efficacy of extracorporeal shock wave (ESW) and teriparatide-loaded hydrogel (T-Gel) combined strategy on osteoporosis bone marrow mesenchymal stem cells (OP-BMSCs) in vitro and bone regeneration in vivo. The results showed that the combination of ESW and T-Gel significantly enhanced OP-BMSCs proliferation, survival, migration, and osteogenic differentiation, leading to enhanced bone healing in osteoporotic segmental bone defects.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

Review Cell & Tissue Engineering

The effects and potential applications of concentrated growth factor in dentin-pulp complex regeneration

Zixia Li et al.

Summary: Traditional approaches for preserving the integrity of the dentin-pulp complex have limitations, leading to the exploration of novel methods like stem cell-based tissue engineering. Concentrated growth factor serves as a promising scaffold due to its autogenesis, convenience, usability, and biodegradability, and has gained popularity in medical and dental fields for various applications. Studies show that concentrated growth factor can promote stem cell proliferation and migration, highlighting its potential for dentin-pulp complex regeneration.

STEM CELL RESEARCH & THERAPY (2021)

Article Medicine, Research & Experimental

Bi-directional regulation functions of lanthanum-substituted layered double hydroxide nanohybrid scaffolds via activating osteogenesis and inhibiting osteoclastogenesis for osteoporotic bone regeneration

Min Chu et al.

Summary: La-LDH nanohybrid scaffolds exhibit dual functions of promoting osteogenesis and inhibiting osteoclastogenesis, showing potential value for bone regeneration in osteoporotic patients.

THERANOSTICS (2021)

Article Dentistry, Oral Surgery & Medicine

Clinical Application of Concentrated Growth Factor Fibrin Combined With Bone Repair Materials in Jaw Defects

Dongdong Fang et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2020)

Article Engineering, Biomedical

Gelatin Templated Polypeptide Co-Cross-Linked Hydrogel for Bone Regeneration

Yusen Qiao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Review Dentistry, Oral Surgery & Medicine

The use of concentrated growth factor in dental implantology: A systematic review

Bhavna Vasudev Lokwani et al.

JOURNAL OF INDIAN PROSTHODONTIC SOCIETY (2020)

Article Orthopedics

Induced membrane technique in the treatment of infectious bone defect: A clinical analysis

Jianbing Wang et al.

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH (2019)

Article Dentistry, Oral Surgery & Medicine

Effect of concentrated growth factor on osteoblast cell response

I. O. Sahin et al.

JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY (2018)

Article Cell & Tissue Engineering

Angiogenic effect of platelet-rich plasma combined with gelatin hydrogel granules injected into murine subcutis

Natsuko Kakudo et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Article Engineering, Biomedical

Sustained release of multicomponent platelet-rich plasma proteins from hydrolytically degradable PEG hydrogels

Era Jain et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

Review Engineering, Biomedical

The use of platelet-rich plasma in bone reconstruction therapy

Giuseppe Intini

BIOMATERIALS (2009)