期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.989602
关键词
spinal cord injury; neuroprotection; epigallocatechin-3-gallate; selenium nanoparticle; reactive oxygen species; inflammation
资金
- National Natural Science Foundation of China
- Jilin Provincial Science and Technology Program [51803072]
- Jilin Provincial Finance Program [20200201341JC]
- [2019SCZ023]
- [2018SCZ013]
- [2021SCZ07]
EGCG-Se NP shows superior neuroprotective effect in spinal cord injury (SCI) through scavenging reactive oxygen species (ROS) and attenuating inflammation, making it a promising and effective treatment option.
Purpose: Spinal cord injury (SCI) is a severely crippling injury. Scavenging reactive oxygen species (ROS) and suppressing inflammation to ameliorate secondary injury using biomaterials has turned into a promising strategy for SCI recuperation. Herein, epigallocatechin-3-gallate selenium nanoparticles (EGCG-Se NP) that scavenge ROS and attenuate inflammation were used for neuroprotection in SCI. Methods: EGCG-Se NP were arranged using a simple redox framework. The size, morphology, and chemical structure of the EGCG-Se NP were characterized. The protective effect of EGCG-Se NP for neuroprotection was examined in cell culture and in an SCI rat model. Results: EGCG-Se NP could promptly scavenge excess ROS and safeguard PC12 cells against H2O2-induced oxidative harm in vitro. After intravenous delivery in SCI rats, EGCG-Se NP significantly improved locomotor capacity and diminished the injury region by safeguarding neurons and myelin sheaths. Component studies showed that the main restorative impact of EGCG-Se NP was due to their ROS-scavenging and anti-inflammatory properties. Conclusion: This study showed the superior neuroprotective effect of EGCG-Se NP through ROS sequestration and anti-inflammatory capabilities. EGCG-Se NP could be a promising and effective treatment for SCI.
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