4.7 Review

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

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Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions

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Summary: This study investigates the impact of low-density lipoproteins (LDL) on cell migration and invasion, as well as the intracellular transport pathways involving cholesterol. The results show that LDL stimulates cell migration and invasion, but blocking cholesterol export from late endosomes affects cell migration behavior. Additionally, AnxA6 is found to play a regulatory role in cell migration by promoting cholesterol delivery to focal adhesion structures.

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Summary: Identification of new prognostic biomarkers and therapeutic targets is crucial for improving outcomes of bladder cancer patients. This study comprehensively analyzed the mRNA expression and prognosis of Annexin family members in bladder cancer, constructed an Annexin-related prognostic signature, and validated it in four independent cohorts, providing potential insights into the molecular mechanisms of bladder cancer development and suggesting therapeutic targets.

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Summary: Evidence suggests that circ_0000592 plays a role in the progression of gastric cancer by regulating the miR-1179/ANXA4 axis. Knockdown of circ_0000592 inhibited cell proliferation, migration, invasion, and glycolysis in gastric cancer cells, indicating its potential as a therapeutic target for gastric cancer.

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Summary: This study found that ANXA10 knockout increases the sensitivity of GC cells to 5-FU and may serve as a predictive indicator for response to 5-FU treatment in GC patients. Furthermore, ANXA10 may be involved in the pathogenesis of GC in collaboration with genes such as CLDN1, KRT80, RBCK1, and SLC7A5.

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Masako Yumura et al.

Summary: The study revealed that high expression of ANXA10 in lung adenocarcinoma is associated with poor overall survival, and down-regulation of ANXA10 suppresses cancer cell migration. Therefore, high ANXA10 expression is a novel prognostic marker in lung adenocarcinoma.

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Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma

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Summary: The study identified that increased expression of proteins ANXA5 and DDOST is significantly associated with poorer clinical outcomes in cSCC, and can be used to predict the metastasis and survival of patients. The prediction model using these proteins showed higher accuracy, sensitivity, and specificity than current cSCC staging systems in clinical use.

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Summary: The study revealed that the expression levels of Hsa-miR-105-1 were associated with cisplatin resistance in OC cells, and it regulates the sensitivity of OC cells to cisplatin by affecting the expression of ANXA9.

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Summary: ANXA3, a member of the annexin family, plays an important role in malignant tumors by regulating cell processes through various signaling pathways. Abnormal expression of ANXA3 is closely associated with tumor development and prognosis, making it a potential target for early diagnosis and treatment of tumors.

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Ya Peng et al.

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Nina Quiskamp et al.

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Chi-Yun Wang et al.

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Plasma Membrane-associated Annexin A6 Reduces Ca2+ Entry by Stabilizing the Cortical Actin Cytoskeleton

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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Gastroenterology & Hepatology

Expression of Annexin A5 Is Associated With Higher Tumor Stage and Poor Prognosis in Colorectal Adenocarcinomas

Geng Xue et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2009)

Article Biochemistry & Molecular Biology

Annexin-A6 presents two modes of association with phospholipid membranes. A combined QCM-D, AFM and cryo-TEM study

Nikolay Buzhynskyy et al.

JOURNAL OF STRUCTURAL BIOLOGY (2009)

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Annexin A3 in Urine: A Highly Specific Noninvasive Marker for Prostate Cancer Early Detection

Martin Schostak et al.

JOURNAL OF UROLOGY (2009)

Article Biochemistry & Molecular Biology

Annexin A6 inhibits Ras signalling in breast cancer cells

S. Vila de Muga et al.

ONCOGENE (2009)

Article Multidisciplinary Sciences

Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice

Ming Yi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Pathology

New markers of pancreatic cancer identified through differential gene expression analyses: Claudin 18 and annexin A8

Zarir E. Karanjawala et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2008)

Review Pharmacology & Pharmacy

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems

F. D'Acquisto et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Review Biochemistry & Molecular Biology

S100-annexin complexes - structural insights

Anne C. Rintala-Dempsey et al.

FEBS JOURNAL (2008)

Article Oncology

Characterisation and protein expression profiling of annexins in colorectal cancer

R. Duncan et al.

BRITISH JOURNAL OF CANCER (2008)

Review Physiology

S100A10/p11: family, friends and functions

Ursula Rescher et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Annexin 1: the new face of an old molecule

Lina H. K. Lim et al.

FASEB JOURNAL (2007)

Article Biochemistry & Molecular Biology

Requirement for annexin A1 in plasma membrane repair

Anna K. McNeil et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Protein kinase C δ (δPKC)-annexin V interaction -: A required step in δPKC translocation and function

Viktoria Kheifets et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Annexin A8 displays unique phospholipid and F-actin binding properties

Verena Goebeler et al.

FEBS LETTERS (2006)

Article Biochemistry & Molecular Biology

Annexin A3 is a potential angiogenic mediator

JE Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Letter Biochemistry & Molecular Biology

Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells

A Petrella et al.

CELL DEATH AND DIFFERENTIATION (2005)

Article Biochemistry & Molecular Biology

Structure-function relationship in annexin A13, the founder member of the vertebrate family of annexins

J Turnay et al.

BIOCHEMICAL JOURNAL (2005)

Review Cell Biology

Annexins:: Linking Ca2+ signalling to membrane dynamics

V Gerke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Review Cell Biology

Annexin-actin interactions

MJ Hayes et al.

TRAFFIC (2004)

Article Biochemistry & Molecular Biology

Annexin 2 expression is reduced in human osteosarcoma metastases

JM Gillette et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)

Article Cell Biology

Annexins - unique membrane binding proteins with diverse functions

U Rescher et al.

JOURNAL OF CELL SCIENCE (2004)

Article Biochemistry & Molecular Biology

An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface

AB Deora et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biotechnology & Applied Microbiology

The annexins

SE Moss et al.

GENOME BIOLOGY (2004)

Article Biochemistry & Molecular Biology

A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils

E Solito et al.

FASEB JOURNAL (2003)

Article Clinical Neurology

Prognostic significance of annexin VII expression in glioblastomas multiforme in humans

KS Hung et al.

JOURNAL OF NEUROSURGERY (2003)

Article Oncology

Phosphatidylserine is a marker of tumor vasculature and a potential target for cancer imaging and therapy

S Ran et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2002)

Article Biochemistry & Molecular Biology

Aberrant inflammation and resistance to glucocorticoids in Annexin 1-/- Mouse

R Hannon et al.

FASEB JOURNAL (2002)

Review Physiology

Annexins: From structure to function

V Gerke et al.

PHYSIOLOGICAL REVIEWS (2002)

Article Biochemistry & Molecular Biology

Annexin 2 has an essential role in actin-based macropinocytic rocketing

CJ Merrifield et al.

CURRENT BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Activation of Raf-1 is defective in annexin 6 overexpressing Chinese hamster ovary cells

M Pons et al.

FEBS LETTERS (2001)

Article Multidisciplinary Sciences

ANX7, a candidate tumor suppressor gene for prostate cancer

M Srivastava et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Phosphorylation mutants elucidate the mechanism of annexin IV-mediated membrane aggregation

MA Kaetzel et al.

BIOCHEMISTRY (2001)

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The C terminus of annexin II mediates binding to F-actin

NR Filipenko et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biotechnology & Applied Microbiology

ANX7 as a bio-marker in prostate and breast cancer progression

M Srivastava et al.

DISEASE MARKERS (2001)

Article Biochemistry & Molecular Biology

Structure of membrane-bound annexin A5 trimers:: A hybrid Cryo-EM -: X-ray crystallography study

F Oling et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

Article Oncology

Annexin VII as a novel marker for invasive phenotype of malignant melanoma

TR Kataoka et al.

JAPANESE JOURNAL OF CANCER RESEARCH (2000)