期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.942853
关键词
intrahepatic cholangiocarcinoma; circular RNAs; competing endogenous RNA; expression pattern; regulatory networks
资金
- National Natural Science Foundation of China [81603181]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [19KJB320005]
- Promoting science and education of Suzhou [KJXW2017015]
- Promoting science and education of Wujiang [wwk201723]
- Priority Academic Program of Development of Jiangsu Higher Education Institutions
This study revealed differentially expressed circRNAs in iCCA tissues, suggesting that circRNAs may play crucial roles in iCCA pathogenesis.
Introduction: Intrahepatic cholangiocarcinoma (iCCA) is a heterogeneous entity with diverse etiologies, morphologies, and clinical outcomes, but our knowledge of its epidemiology and carcinogenesis is very limited.Materials and methods: The expression patterns of circRNAs were explored in iCCA tissues and corresponding adjacent normal ones, denoted by (iCCA) and (iCCAP), respectively, using high-throughput sequencing.Results: A total of 117 differential expressed (DE) circRNAs were identified. Based on the parental transcripts of circRNAs, these DE circRNAs were related to several important GO terms and were enriched in important pathways. Two circRNA-mediated ceRNA networks were constructed and many important metabolic pathways related to mRNAs were regulated by DE circRNAs via miRNAs.Conclusion: Our study revealed the DE circRNAs in the iCCA tissues compared with iCCAP ones, suggesting that circRNAs may play crucial roles in the pathogenesis of iCCA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
